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Blue Jays vs White Sox Prediction 6/22/25 MLB Picks Today

Chicago White Sox (24-53) vs. Toronto Blue Jays (41-35)
June 22, 2025 1:37 pm EDT
The Line: Toronto Blue Jays -220 / Chicago White Sox 178; Over/Under: 9
(Get latest betting odds)

The Chicago White Sox and Toronto Blue Jays meet Sunday in MLB action at Rogers Centre. Here’s a Blue Jays vs White Sox Prediction. This article will include a Blue Jays vs White Sox Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 24-53 on the year and play the Diamondbacks, Giants, and Dodgers next. The Chicago White Sox are batting .221 on the season, have a .293 OBP, and a .344 slugging percentage. The Chicago White Sox pitching staff has a 4.24 ERA and a 1.41 WHIP. Miguel Vargas leads the Chicago White Sox with 65 hits and 32 RBI, while Lenyn Sosa and Chase Meidroth have combined for 111 hits and 26 RBI.

Adrian Houser gets the ball for the Chicago White Sox, and he is 2-2 with a 2.15 ERA and 22 strikeouts this season. Houser is 0-2 with a 9.58 ERA and 6 strikeouts in his career against the Toronto Blue Jays.

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 41-35 on the year and play the Guardians, Red Sox, and Yankees next. The Toronto Blue Jays are batting .256 on the season, have a .325 OBP, and a .402 slugging percentage. The Toronto Blue Jays pitching staff has a 4.22 ERA and a 1.24 WHIP. Bo Bichette leads the Toronto Blue Jays with 89 hits and 46 RBI while Vladimir Guerrero Jr. and Ernie Clement have combined for 152 hits and 57 RBI.

Chris Bassitt gets the ball for the Toronto Blue Jays, and he is 7-3 with a 3.75 ERA and 83 strikeouts this season. Bassitt is 5-2 with a 2.94 ERA and 42 strikeouts in his career against the Chicago White Sox.

Why the Toronto Blue Jays will win

  • The White Sox have lost each of their last 11 games against American League opponents following a road loss.
  • The Blue Jays have won eight of their last nine games against the White Sox following a win.
  • The White Sox have failed to cover the run line in each of their last five day games against the Blue Jays following a loss.
  • The Blue Jays have covered the run line in five of their last six games against the White Sox.
  • The White Sox have trailed after 3 innings in each of their last four day games.
  • The White Sox have trailed after 5 innings in each of their last six day games against AL East opponents that held a winning record.
  • The Blue Jays have won the first inning in three of their last four day games against American League opponents that held a losing record.

Why the Chicago White Sox will win

  • The Blue Jays have lost three of their last four games as favorites against AL Central opponents following a win.
  • The road team has won four of the White Sox’s last five games.
  • The White Sox have covered the run line in seven of their last eight games against American League opponents following a loss.
  • The Blue Jays have failed to cover the run line in six of their last seven day games against American League opponents following a home win.
  • The Blue Jays have trailed after 3 innings in five of their last six home games against AL Central opponents.
  • The Blue Jays have trailed after 5 innings in six of their last eight games as favorites.

Toronto Blue Jays Player Prop Facts

  • Bo Bichette has hit a home run in each of his last two appearances in day games against AL Central teams that held a losing record.
  • Bo Bichette has recorded at least one RBI in each of the Blue Jays’ last six games as favorites against the White Sox.
  • Chris Bassitt has recorded a win in each of his last four home appearances against the White Sox.
  • Vladimir Guerrero Jr. has scored at least one run in 12 of the Blue Jays’ last 13 games as favorites against AL opponents.
  • Chris Bassitt has recorded six strikeouts in each of his last three appearances with the Blue Jays as favorites against AL opponents.
  • Daulton Varsho has recorded a Double in four of his last five appearances in day games.
  • Daulton Varsho has recorded at least one hit in each of his last 11 home appearances against opponents that held a losing record.
  • Bo Bichette ranks T5th in the league in Hits (89) this season.

Chicago White Sox Player Prop Facts

  • Miguel Vargas has hit a home run in four of the White Sox’s last five Sunday games.
  • Adrian Houser has recorded a win in three of his last four appearances in day games against AL teams that held a winning record.
  • Luis Robert has recorded at least one RBI in three of his last four appearances with the White Sox as road underdogs.
  • Miguel Vargas has scored at least one run in each of the White Sox’s last six road games.
  • Adrian Houser has recorded six strikeouts in each of his last three appearances in day games.
  • Mike Tauchman has recorded at least one hit in 10 of his last 11 road appearances.
  • Luis Robert ranks 4th in the league in Steals (22) this season.

Blue Jays vs White Sox Prediction

Another White Sox game, another chance to fade them. We’ve been doing it for years and it’s made some nice coin. The White Sox just don’t win games and pack zero betting value. Houser was solid this season for the Rangers, but now he pitches for a team where pitchers go to die. The Blue Jays ave quietly been a good team over the last month, and Bassitt has a 2.74 ERA and .260 allowed batting average in 46 home innings. The Blue Jays are a team to watch in the AL if they can keep form. Give me the Blue Jays and the RL for max betting value.

Randy Chambers's Free Pick: Toronto Blue Jays -1.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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