Brewers vs Cardinals Prediction 5/4/26 MLB Picks Today

In this article, we will formulate a Brewers vs Cardinals Prediction for this MLB matchup on Monday, May 4^th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 20-14 record this season and are sitting in the second place of the NL Central. They have a 9-9 home record and are coming off a 1-4 home loss against the Dodgers. Their previous three games were a 3-2 win and a 7-2 win at home against the Dodgers, and a 10-5 win on the road against the Pirates.

The Cardinals have a .241 batting average this season, .325 OBP and .403 Slugging percentage. St. Louis’ pitching staff has a 4.54 ERA and 1.42 WHIP. Jordan Walker is the team’s best hitter with a .307 batting average. Alec Burleson leads the team in RBI with 28, and Jordan Walker adds a team‑high 10 home runs.

Kyle Leahy (R) is the projected starting pitcher for the Cardinals, and he has a 3-3 record, 5.52 ERA and 1.67 WHIP.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 18-15 record this season and are sitting in the fourth place of the NL Central. They have an 8-7 away record and are coming off a 2-3 loss on the road against the Nationals. Their previous three games were a 4-1 win and a 6-1 win on the road against the Nationals, and a 13-1 win at home against the Diamondbacks.

The Brewers have a .239 batting average this season, .335 OBP and .354 Slugging percentage. Milwaukee’s pitching staff has a 3.56 ERA and 1.25 WHIP. William Contreras is the team’s best hitter with a .298 batting average, also leading the team in RBI with 23. Gary Sanchez adds a team‑high 5 home runs.

Chad Patrick (R) is the projected starting pitcher for the Brewers, and he has a 2-1 record, 2.57 ERA and 1.25 WHIP.

Milwaukee Brewers @ St. Louis Cardinals Betting Trends: May 4, 2026

• Probable Starting Pitcher: Kyle Leahy      Record this season: 3-3      ERA: 5.52
• Home Record: 0-2
• Last 5 against Brewers: 1-1

Why the St. Louis Cardinals will win

• The Cardinals have won eight of their last nine games as underdogs against National League opponents following a home loss.
• The Brewers have lost seven of their last eight games as road favorites following a road loss.
• The Brewers have failed to cover the run line in each of their last 11 games as road favorites following a road loss.
• The Cardinals have covered the run line each of their last six night games against teams that held a winning record.
• The Cardinals have led after 3 innings in each of their last four night games.
• The Brewers have lost the first inning in each of their last four road games against National League opponents that held a winning record.
• The Cardinals have led after 5 innings in each of their last five games against the Brewers.

• Probable Starting Pitcher: Chad Patrick      Record this season: 2-1      ERA: 2.57
• Road Record: 1-1
• Last 5 against Cardinals: 0-1

Why the Milwaukee Brewers will win

• The Brewers have won each of their last five games against the Cardinals following a loss.
• The Cardinals have lost five of their last six home games following a loss.
• The Cardinals have failed to cover the run line in each of their last six Monday home games.
• The Brewers have covered the run line in five of their last six games against the Cardinals following a road loss.
• The Brewers have led after 3 innings in five of their last six games.
• The Brewers have won the first inning in four of their last five games.
• The Cardinals have trailed after 5 innings in each of their last five Monday games.

Total Runs Facts

• Seven of the Cardinals’ last eight home games against National League opponents have gone UNDER the total runs line.
• Five of the Brewers’ last six games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Brewers’ last six games as road favorites against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the last six night games between the Brewers and Cardinals at Busch Stadium.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in two of the Cardinals’ last three night games.
• Alec Burleson has recorded at least one hit in each of his 10 previous appearances with the Cardinals as home underdogs against the Brewers.
• Jordan Walker ranks T8th in the league in Home Runs (10) this season.

Milwaukee Brewers Player Prop Facts

• Sal Frelick has recorded at least one hit in each of his last 11 road appearances against NL Central opponents.
• Gary Sanchez has hit a home run in four of his last five road appearances against NL Central opponents that held a winning record.
• Brice Turang ranks 4th amongst qualified players for On Base Percentage (.428) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for strikeouts this season (236).
• The Cardinals rank T4th in the league for home runs this season (44).
• The Brewers rank 1st in the league for steals this season (38).
• The Brewers rank T1st in the league for walks this season (155).

Brewers vs Cardinals Prediction

The Cardinals are 3-1 in their last 4 meetings against the Brewers and are 2-1 in their last three meetings in Saint Louis. Under is 3-1 in their last 4 meetings.

In this Brewers vs Cardinals Prediction, the Brewers are coming as -115 road favorites. Both teams are coming off defeats yesterday and the Brewers have the pitching advantage with Chad Patrick on the mound, who has given up just four runs in four starts this season. Kyle Leahy has 10 earned runs in his last three starts for the Cardinals, who have both a weaker offense and a weaker bullpen as the Brewers are even better against right-handed pitching, with 5.9 runs/9. Take the Brewers to win this one on the road.