Brewers vs Cardinals Prediction 6/12/25 MLB Picks Today

The St. Louis Cardinals and Milwaukee Brewers meet Thursday in MLB action at American Family Field. Here’s a Brewers vs Cardinals Prediction. This article will include a Brewers vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 36-32 on the year and play the White Sox, Reds, and Cubs next. The St. Louis Cardinals are batting .257 on the season, have a .327 OBP, and a .395 slugging percentage. The St. Louis Cardinals’ pitching staff has a 3.94 ERA and a 1.28 WHIP. Brendan Donovan leads the St. Louis Cardinals with 77 hits and 26 RBI, while Willson Contreras and Lars Nootbaar have combined for 122 hits and 71 RBI.

Sonny Gray gets the ball for the St. Louis Cardinals, and he is 7-1 with a 3.35 ERA and 81 strikeouts this season. Gray is 4-5 with a 3.23 ERA and 120 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 36-33 on the year and play the Cubs, Twins, and Pirates next. The Milwaukee Brewers are batting .234 on the season, have a .313 OBP, and a .361 slugging percentage. The Milwaukee Brewers’ pitching staff has a 3.86 ERA and a 1.31 WHIP. Jackson Chourio leads the Milwaukee Brewers with 75 hits and 39 RBI, while Sal Frelick and Brice Turang have combined for 130 hits and 46 RBI.

Jacob Misiorowski will make his major league debut when he takes the mound. Misiorowski was 11-9 with a 3.04 ERA and 320 strikeouts in his minor league career. In 13 games in AAA this year, Misiorowski was 4-2 with a 2.13 ERA and 80 strikeouts. 

Why the Milwaukee Brewers will win

• The Cardinals have lost each of their last seven games as road favorites against NL Central opponents.
• The Brewers have won each of their last five games as home underdogs against the Cardinals following a home loss.
• The Cardinals have failed to cover the run line in each of their last 10 games as road favorites against NL Central opponents.
• The Brewers have covered the run line in each of their last nine Thursday games as underdogs against the Cardinals.
• The Cardinals have trailed after 5 innings in each of their last four games.
• The Cardinals have lost the first inning in five of their last six night games.
• The Brewers have led after 3 innings in each of their last four games against NL Central opponents.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last eight night games against National League opponents.
• The Brewers have lost each of their last three night games against NL Central opponents that held a winning record.
• The Cardinals have covered the run line in each of their last eight night games against National League opponents.
• The Brewers have failed to cover the run line in eight of their last nine night games against the Cardinals following a home loss.
• The Cardinals have led after 3 innings in five of their last six games as favorites against National League opponents.
• The Brewers have trailed after 5 innings in six of their last seven night games against opponents that held a winning record.
• The Cardinals have won the first inning in each of their last four night games against NL Central opponents that held a winning record.

Milwaukee Brewers Player Prop Facts

• Jackson Chourio has recorded a Double in each of the Brewers’ last five games against the Cardinals.
• Jackson Chourio has recorded at least one hit in each of the Brewers’ last eight games against the Cardinals.
• Rhys Hoskins has recorded at least one RBI in six of his last eight home appearances against the Cardinals.
• Christian Yelich has scored at least one run in each of his last six home appearances against the Cardinals.
• Rhys Hoskins has hit a home run in each of his last two appearances with his team as a home underdog against the Cardinals.
• Christian Yelich has recorded at least one Single in each of his last seven appearances against the Cardinals.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in each of his last two road appearances against opponents that held a winning record.
• Masyn Winn has recorded at least one Single in each of the Cardinals’ last eight night games against opponents that held a winning record.
• Sonny Gray has recorded six or more strikeouts in 15 of his last 16 appearances with his team as a favorite against NL Central opponents.
• Nolan Arenado has recorded a Double in four of his last five appearances in night games against NL Central teams that held a winning record.
• Brendan Donovan has recorded at least one hit in each of the Cardinals’ last 13 games as favorites against NL Central opponents.
• Willson Contreras has recorded at least one RBI in each of the Cardinals’ last seven games as favorites.
• Sonny Gray has recorded a win in four of his last five appearances with the Cardinals as favorites.
• Lars Nootbaar has scored at least one run in seven of the Cardinals’ last eight night games against NL opponents that held a winning record.

Brewers vs Cardinals Prediction

I have a rule of not betting pitchers making their MLB debut, as you truly don’t know what to expect. There’s no sample size on this level. The Cardinals are going to be favored anyway with the way Gray has pitched this season. However, the Cardinals have been rough this week and are riding four straight losses.

Also, Misiorowski isn’t your typical rookie making his debut, as he’s a top-100 prospect with a fastball that can hit triple digits and a slider with crazy movement. Misiorowski is the top pitching prospect in the Brewers system and is expected to be something. We’re getting plus money with a super talented kid. I’ll take a shot with the Brewers.