Brewers vs Cardinals Prediction 9/13/25 MLB Picks Today

The St. Louis Cardinals and Milwaukee Brewers meet Saturday in MLB action at American Family Field. Here’s a Brewers vs Cardinals Prediction. This article will include a Brewers vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 72-76 on the year and play the Reds, Brewers, and Giants next. The St. Louis Cardinals are batting .245 on the season, have a .313 OBP, and a .379 slugging percentage. The St. Louis Cardinals pitching staff has a 4.27 ERA and a 1.32 WHIP. Alec Burleson leads the St. Louis Cardinals with 127 hits and 63 RBI, while Masyn Winn and Willson Contreras have combined for 247 hits and 129 RBI.

Sonny Gray gets the ball for the St. Louis Cardinals, and he is 13-8 with a 4.45 ERA and 179 strikeouts this season. Gray is 4-6 with a 3.64 ERA and 124 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 90-58 on the year and play the Angels, Cardinals, and Padres next. The Milwaukee Brewers are batting .260 on the season, have a .333 OBP, and a .408 slugging percentage. The Milwaukee Brewers pitching staff has a 3.62 ERA and a 1.23 WHIP. Brice Turang leads the Milwaukee Brewers with 155 hits and 75 RBI while Sal Frelick and William Contreras have combined for 282 hits and 126 RBI.

Brandon Woodruff gets the ball for the Milwaukee Brewers, and he is 6-2 with a 3.32 ERA and 74 strikeouts this season. Woodruff is 6-4 with a 2.54 ERA and 77 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 13, 2025

• Probable Starting Pitcher: Jacob Misiorowski      Record this season: 5-2      ERA: 4.09
• Home Record: 3-0
• Last 5 against Cardinals: 1-0

Why the Milwaukee Brewers will win

• The Brewers have won each of their last nine games against NL Central opponents that held a losing record.
• The Cardinals have lost each of their last five road games.
• The Brewers have covered the run line each of their last nine games against NL Central opponents that held a losing record.
• The Cardinals have failed to cover the run line in each of their last six games following a road loss.
• The Brewers have led after 3 innings in each of their last six home games against NL Central opponents that held a losing record.
• The Brewers have led after 5 innings in each of their last six home games against NL Central opponents that held a losing record.
• The Cardinals have lost the first inning in three of their last four road games against NL Central opponents that held a winning record.

• Probable Starting Pitcher: Sonny Gray      Record this season: 13-8      ERA: 4.45
• Road Record: 4-3
• Last 5 against Brewers: 0-3

Why the St. Louis Cardinals will win

• The Brewers have lost each of their last four games as home favorites after playing the previous day.
• The Cardinals have won each of their last six Saturday games as road underdogs.
• The Brewers have failed to cover the run line in eight of their last nine home games after playing the previous day.
• The Cardinals have covered the run line in each of their last six Saturday games as road underdogs.
• The Brewers have trailed after 5 innings in three of their last four games.

Total Runs Facts

• Six of the Brewers’ last seven home games against NL Central opponents have gone OVER the total runs line.
• Six of the Cardinals’ last seven road games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last seven Saturday night games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Cardinals’ last seven games as underdogs.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit a home run in four of his last five appearances in night games against NL Central teams that held a losing record.
• Christian Yelich has recorded at least one hit in each of his last 19 appearances against NL Central opponents that held a losing record.

St. Louis Cardinals Player Prop Facts

• Sonny Gray has recorded six or more strikeouts in 12 of his last 13 appearances with his team as an underdog against NL Central opponents.
• Sonny Gray has recorded a win in three of his last four appearances against NL opponents that held a winning record.
• Willson Contreras has hit a home run in four of his last seven road appearances after playing the previous day.
• Brendan Donovan has recorded a Double in three of his last four appearances against the Brewers after playing the previous day.
• Brendan Donovan has recorded at least one hit in each of his last eight appearances against the Brewers.

Brewers vs Cardinals Prediction

The Cardinals are having a rough week and Gray has fallen off a bit, allowing 13 hits and 10 runs in his last 11.1 innings. In 56.2 road innings, Gray has a 5.24 ERA and .244 allowed batting average. The Brewers aren’t as hot as they used to be, but they’re still a hell of a team, and Woodruff has been sharp with a 3.32 ERA and 0.96 WHIP on the season. Woodruff is coming off 6 shutout innings against the Pirates. The Brewers have been kind to us all year, and I’m still here, a loyal supporter. Give me the Brewers.