Brewers vs Cardinals Prediction 9/20/25 MLB Picks Today

In this article, we will formulate a Brewers vs Cardinals Prediction for this MLB game on Saturday, September 20^th at the Busch Stadium in the second game of this series, with the Cardinals having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 75-79 record this season and are sitting on the 4^th place of the NL Central. The Cardinals have a 43-36 home record and are 77-69 in over/under. They are coming off a 7-1 home victory over the Brewers, but are still 3-7 in their last 10 games. They are playing the Cubs and the Giants next.

The Cardinals have a .245 batting average this season, .316 OBP and .379 Slugging percentage. Saint Louis’ pitching staff has a 4.27 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 136 hits, and he is the team’s best hitter with a .289 batting average. Wilson Contreras leads the team in RBI, with 80, adding a team-high 20 home runs.

Miles Mikolas (R) is the projected starting pitcher for the Cardinals, and he has an 8-10 record, 4.80 ERA and 1.31 WHIP.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 94-60 record this season and are sitting on the first place of the NL Central. They have a 43-33 road record and are 75-74 in over/under. They are coming off a 1-7 road defeat by the Cardinals, that ended their three-game winning streak. Over is 8-2 in their last 10 games and are playing the Reds and the Padres next.

The Brewers have a .261 batting average this season, .334 OBP and .409 Slugging percentage. Milwaukee’s pitching staff has a 3.62 ERA and 1.23 WHIP. Brice Turang leads the Brewers with 160 hits, while Christian Yelich leads the team in RBI, with 100, adding a team-high 29 home runs. Sal Frelick is the team’s best hitter with a .295 batting average.

Chad Patrick (R) is the projected starting pitcher for the Brewers, and he has a 3-8 record, 3.64 ERA and 1.28 WHIP.

Milwaukee Brewers @ St. Louis Cardinals Betting Trends: September 20, 2025

• Probable Starting Pitcher: Miles Mikolas      Record this season: 8-10      ERA: 4.80
• Home Record: 4-4
• Last 5 against Brewers: 2-2

Why the St. Louis Cardinals will win

• The Brewers have lost each of their last four games as road favorites.
• The Cardinals have won five of their last six games as home underdogs.
• The Brewers have failed to cover the run line in each of their last seven games as road favorites following a road loss.
• The underdogs have covered the run line in nine of the Cardinals’ last 10 games at Busch Stadium.
• The Cardinals have won the first inning in four of their last five games as underdogs.
• The Brewers have trailed after 5 innings in each of their last four road games.
• The Cardinals have led after 3 innings in each of their last five games as underdogs.

• Probable Starting Pitcher: Chad Patrick      Record this season: 3-8      ERA: 3.64
• Road Record: 1-4
• Last 5 against Cardinals: 0-1

Why the Milwaukee Brewers will win

• The Brewers have won each of their last 10 Saturday night road games against NL Central opponents.
• The Cardinals have lost each of their last four home games against NL Central opponents following a win.
• The Cardinals have failed to cover the run line in each of their last nine home games against National League opponents following a home win.
• The Brewers have covered the run line in 10 of their last 11 road games against teams that held a losing record.
• The Brewers have led after 5 innings in each of their last eight Saturday night road games.

Total Runs Facts

• Six of the Cardinals’ last seven home games after playing the previous day have gone UNDER the total runs line.
• Four of the Brewers’ last five road games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last six Saturday games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Brewers’ last five night games at Busch Stadium.

St. Louis Cardinals Player Prop Facts

• Nolan Arenado has hit a home run in five of his last 12 home appearances against the Brewers after playing the previous day.
• Brendan Donovan has recorded a Double in each of the Cardinals’ last three home games against the Brewers.
• Miles Mikolas has recorded three or more strikeouts in each of his last 20 appearances against the Brewers.
• Alec Burleson has recorded at least one hit in each of his eight previous appearances with the Cardinals as home underdogs against the Brewers.
• Victor Scott II ranks T10th in the league in Steals (33) this season.

Milwaukee Brewers Player Prop Facts

• Sal Frelick has hit a home run in each of his last two appearances.
• Jackson Chourio has recorded a Double in four of the Brewers’ last five road games against the Cardinals.
• Andrew Vaughn has recorded at least one hit in each of his last nine road appearances against opponents that held a losing record.
• Sal Frelick ranks 10th amongst qualified players for Batting Average (.295) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1146).
• The Brewers rank T2nd in the league for runs scored this season (786).
• The Brewers rank 2nd in the league for hits this season (1369).

Brewers vs Cardinals Prediction

The Brewers are 6-3 in their last 9 head-to-head meetings against the Cardinals, but the Cardinals are 3-1 in their last 4 meetings in Saint Louis. Over is 3-1 in their last 4 meetings.

In this Brewers vs Cardinals Prediction, the Brewers are coming as -150 road favorites. The Brewers finally cooled off with a defeat yesterday, and they are putting Chad Patrick on the mound today, who has been weaker on the road, with a 4.60 ERA, and in terrible form lately, having lost his last 5 starts. On the flip side, Mikolas has been better at home for the Cardinals, with a 3.40 ERA, and has two earned runs or less in his last four starts. I like the value with the home dog in this matchup, so take the Saint Louis Cardinals on the moneyline.