Brewers vs Cubs Prediction 8/21/25 MLB Picks Today

In this article, we will formulate a Brewers vs Cubs Prediction for this MLB game on Thursday, August 21^st at the Wrigley Field in the 5^th game of this series, with the Cubs having the 3-1 lead. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have a 73-54 record this season and are sitting on the second place of the NL Central. The Cubs have a 41-24 home record and are 58-58 in over/under. They are coming off a 4-3 home victory over the Brewers, and have three consecutive wins. Under is 8-2-1 in their last 11 games, and are playing the Angels and the Giants next.

The Cubs have a .250 batting average this season, .319 OBP and .429 Slugging percentage. Chicago’s pitching staff has a 3.81 ERA and 1.21 WHIP. Nico Hoerner leads the Cubs with 133 hits, and he is the team’s best hitter with a .289 batting average. Seiya Suzuki leads the team in RBI, with 86, adding a team-high 27 home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has an 8-5 record, 3.06 ERA and 0.95 WHIP.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 79-48 record this season and are sitting on the first place of the NL Central. They have a 37-28 road record and are 60-64 in over/under. They are coming off a 3-4 road defeat by the Cubs, and have three consecutive losses. Under is 4-2 in their last 6 games, and are playing the Giants and the Diamondbacks next.

The Brewers have a .258 batting average this season, .332 OBP and .406 Slugging percentage. Milwaukee’s pitching staff has a 3.58 ERA and 1.23 WHIP. Brice Turang leads the Brewers with 130 hits, while Christian Yelich leads the team in RBI, with 87, adding a team-high 26 home runs. Sal Frelick is the team’s best hitter with a .298 batting average.

Quinn Priester (R) is the projected starting pitcher for the Brewers, and he has a 11-2 record, 3.48 ERA and 1.24 WHIP.

Why the Chicago Cubs will win

• The Cubs have won five of their last six games.
• The Brewers have lost four of their last five games.
• The Cubs have covered the run line in five of their last six games against National League opponents that held a winning record.
• The Brewers have failed to cover the run line each of their last three games against teams that held a winning record.
• The Cubs have led after 3 innings in five of their last six games against National League opponents that held a winning record.
• The Cubs have led after 5 innings in five of their last six games against National League opponents that held a winning record.
• The Cubs have won the first inning in three of their last four games as favorites against the Brewers.

Why the Milwaukee Brewers will win

• The Brewers have won each of their last nine day games following a loss.
• The Cubs have lost six of their last seven games as favorites following a win.
• The Brewers have covered the run line in each of their last 15 games as road underdogs against NL Central opponents following a road loss.
• The Cubs have failed to cover the run line in each of their last 11 games as favorites following a win.
• The Brewers have led after 3 innings in nine of their last 11 games as underdogs against NL Central opponents.
• The Brewers have led after 5 innings in seven of their last eight Thursday games against NL Central opponents that held a winning record.

Total Runs Facts

• Ten of the Brewers’ last 13 day games after playing the previous day have gone OVER the total runs line.
• Twelve of the Cubs’ last 16 games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Cubs’ last eight games as home favorites against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the Brewers’ last 12 games as road underdogs.

Matchup/League Facts

• The Cubs rank 1st in the league for walks allowed this season (334).
• The Cubs rank 3rd in the league for steals this season (133).
• The Brewers rank 2nd in the league for batting average this season (.258).
• The Brewers rank 2nd in the league for on-base percentage this season (.332).

Brewers vs Cubs Prediction

The Cubs have won their last three meetings against the Brewers, and are 4-2 in their last 6 meetings in Chicago.

In this Brewers vs Cubs Prediction, the Cubs are coming as -145 home favorites. Both pitchers have been excellent throughout the season, but they both are in a slump lately. Imanaga is 1-3 in his last four starts and has 14 earned runs in 20.3 innings pitched in that span. Priester is coming off his worst start of the season, where he gave up 6 runs in 4.1 innings pitched against the Mets. Both pitchers have 2+ earned run in their three starts against the opposing team this season, and the Brewers are the second-best team against lefties this season. Both teams also have top-5 offenses, averaging 10 runs per game, so i don’t expect a pitchers duel today as most people would think. The total is set at just 6.5 runs, which is too low, as three of the four games of the series have gone over that number. Take the over.