Brewers vs Cubs Prediction 10/6/25 MLB Picks Today

The Chicago Cubs and Milwaukee Brewers meet Monday in Game 2 NLDS MLB action at American Family Field. Here’s a Brewers vs Cubs Prediction. This article will include a Brewers vs Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs need a bounce back effort to even up the series at 1-1. The Chicago Cubs are batting .238 on the season, have a .282 OBP, and a .426 slugging percentage. The Chicago Cubs pitching staff has a 2.57 ERA and a 1.17 WHIP. Nico Hoerner leads the Chicago Cubs with 5 hits and 2 RBI, while Michael Busch and Pete Crow-Armstrong have combined for 9 hits and 3 RBI.

Shota Imanaga gets the ball for the Chicago Cubs, and he is 9-8 with a 3.73 ERA and 117 strikeouts this season. Imanaga is 0-0 with a 4.50 ERA and 3 strikeouts in his postseason career. Imanaga is 1-3 with a 5.73 ERA and 18 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers look for another win to take a quick 2-0 series lead. The Milwaukee Brewers are batting .351 on the season, have a .429 OBP, and a .459 slugging percentage. The Milwaukee Brewers pitching staff has a 3.00 ERA and a 1.00 WHIP. Jackson Chourio leads the Milwaukee Brewers with 3 hits and 3 RBI while Blake Perkins and William Contreras have combined for 4 hits and 2 RBI.

Aaron Ashby gets the ball for the Milwaukee Brewers, and he is 5-2 with a 2.16 ERA and 76 strikeouts this season. Ashby is 0-0 with a 9.00 ERA and 4 strikeouts in his postseason career. Ashby is 2-1 with a 5.33 ERA and 33 strikeouts in his career against the Chicago Cubs.

The Chicago Cubs @ Milwaukee Brewers Betting Trends: October 6, 2025

• Probable Starting Pitcher: Aaron Ashby      Record this season (inc. playoffs): 5-2      ERA: 2.12
• Home Record: 1-1
• Last 5 against Cubs: 0-0

Why the Milwaukee Brewers will win

• The favorites have won each of the Cubs’ last nine games.
• The Cubs have lost each of their last five road games.
• The favorites have covered the run line in each of the Cubs’ last nine games.
• The Cubs have failed to cover the run line in each of their last five road playoff games.
• The Cubs have trailed after 5 innings in each of their last six games as underdogs.
• The Cubs have lost the first inning in each of their last three games as underdogs.
• The Brewers have led after 3 innings in each of their last eight Monday games against National League opponents that held a winning record.

• Probable Starting Pitcher: Shota Imanaga      Record this season (inc. playoffs): 9-8      ERA: 3.75
• Road Record: 5-5
• Last 5 against Brewers: 1-3

Why the Chicago Cubs will win

• The Brewers have lost each of their last six night games against teams that held a winning record.
• The Cubs have won four of their last five playoff games as underdogs following a loss.
• The Brewers have failed to cover the run line in each of their last seven night games against National League opponents.
• The Cubs have covered the run line in 16 of their last 18 games as underdogs against National League opponents following a road loss.
• The Cubs have led after 5 innings in five of their last six road night playoff games.
• The Cubs have won the first inning in three of their last four night games at American Family Field.
• The Brewers have trailed after 3 innings in five of their last six playoff games against NL Central opponents.

Total Runs Facts

• Each of the last four games between the Cubs and Brewers at American Family Field have gone OVER the total runs line.
• Each of the Cubs’ last four playoff games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last four night games at American Family Field.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last three games as underdogs.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit a home run in three of his last five home appearances after not playing the previous day.
• Brice Turang has recorded at least one hit in each of the Brewers’ last nine games against NL Central opponents that held a winning record.
• Jackson Chourio has recorded a Double in four of his last five appearances against the Cubs after not playing the previous day.

Chicago Cubs Player Prop Facts

• Nico Hoerner has hit a home run in three of the Cubs’ last four games as road underdogs against the Brewers.
• Ian Happ has recorded a Double in four of the Cubs’ last five night games.
• Ian Happ has recorded at least one hit in each of the Cubs’ last seven road games against the Brewers.
• Nico Hoerner ranks 6th in the league in Hits (178) this season.

Matchup/League Facts

• The Brewers rank 2nd in the league for on-base percentage this season (.332).
• The Brewers rank 2nd in the league for steals this season (164).
• The Cubs rank 1st in the league for walks allowed this season (405).
• The Cubs rank T3rd in the league for RBIs this season (771).

Brewers vs Cubs Prediction

The Cubs will have their chances with Imanaga on the mound, as he’s been solid in two years, and he has a 3.44 ERA and .220 allowed batting average in 73.1 road innings. However, the Cubs have lost 4 of Imanaga’s last 5 starts, and he wasn’t great in 4 innings against the Padres, his postseason debut.

I have no idea what to expect from a bullpen game from the Brewers, but they finished the season with the best record in baseball, and they’ve made MLB bettors a pretty penny. Until that stops, you kind of have to keep showing up at the well. It seems like people are writing off the Brewers and aren’t believers in what they accomplished all year. The profit speaks for itself, folks. Give me the Brewers once again.