Brewers vs Orioles Prediction 5/21/25 MLB Picks Today

The Baltimore Orioles and Milwaukee Brewers meet Wednesday in MLB action at American Family Field. Here’s a Brewers vs Orioles Prediction. This article will include a Brewers vs Orioles Pick.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 15-32 on the year and play the Red Sox, Cardinals, and White Sox next. The Baltimore Orioles are batting .230 on the season, have a .297 OBP, and a .386 slugging percentage. The Baltimore Orioles pitching staff has a 5.53 ERA and a 1.49 WHIP. Gunnar Henderson leads the Baltimore Orioles with 41 hits and 13 RBI, while Jackson Holliday and Ryan O’Hearn have combined for 77 hits and 32 RBI.

Tomoyuki Sugano gets the ball for the Baltimore Orioles, and he is 4-3 with a 3.08 ERA and 29 strikeouts this season. This will be Sugano’s first career game against the Milwaukee Brewers.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 24-25 on the year and play the Pirates, Red Sox, and Phillies next. The Milwaukee Brewers are batting .230 on the season, have a .309 OBP, and a .351 slugging percentage. The Milwaukee Brewers’ pitching staff has a 4.09 ERA and a 1.32 WHIP. Brice Turang leads the Milwaukee Brewers with 51 hits and 19 RBI, while Jackson Chourio and Sal Frelick have combined for 93 hits and 39 RBI.

Chad Patrick gets the ball for the Milwaukee Brewers, and he is 2-4 with a 3.35 ERA and 38 strikeouts this season. This will be Patrick’s first career game against the Baltimore Orioles.

Why the Milwaukee Brewers will win

• The Orioles have lost each of their last 10 games against NL Central opponents that held a losing record.
• The favorites have won each of the Brewers’ last eight games at American Family Field.
• The Orioles have failed to cover the run line in nine of their last 10 games against NL Central opponents that held a losing record.
• The Brewers have covered the run line in each of their last four day games against American League opponents.
• The Brewers have led after 3 innings in each of their last 11 games as home favorites.
• The Orioles have lost the first inning in each of their last four day games against opponents that held a losing record.
• The Orioles have trailed after 5 innings in each of their last seven games against NL Central opponents that held a losing record.

Why the Baltimore Orioles will win

• The underdogs have won six of the Orioles’ last eight games.
• The Brewers have lost four of their last five day games against AL East opponents.
• The road team has covered the run line in eight of the Orioles’ last nine games.
• The Brewers have failed to cover the run line in five of their last six games against American League opponents following a win.
• The Brewers have trailed after 3 innings in five of their last six day games against AL East opponents.
• The Brewers have lost the first inning in five of their last six day games against AL East opponents.

Milwaukee Brewers Player Prop Facts

• Rhys Hoskins has hit a home run in four of the Brewers’ last 10 games as home favorites.
• Rhys Hoskins has recorded at least one RBI in five of the Brewers’ last six games as home favorites against AL opponents.
• Rhys Hoskins has recorded a Double in four of the Brewers’ last five games as home favorites against AL opponents.
• Sal Frelick has recorded at least one hit in each of his last 12 appearances with the Brewers as home favorites.
• Brice Turang has recorded at least one Single in each of his last nine home appearances against AL opponents that held a losing record.
• Brice Turang has scored at least one run in each of the Brewers’ last seven games as favorites against AL East opponents.

Baltimore Orioles Player Prop Facts

• Ramon Urias has recorded an RBI in four of his last five appearances against NL opponents.
• Ramon Urias has scored at least one run in each of his last five road appearances against NL Central opponents.
• Ryan Mountcastle has recorded at least one hit in each of his last 12 appearances in day games against teams that held a losing record.
• Gary Sanchez has recorded at least one Single in each of his last six appearances at American Family Field against NL Central opponents that held a losing record.
• Ramon Laureano has hit at least one home run in three of his last five appearances against NL Central opponents.
• Jordan Westburg has recorded at least one Double in three of his last four appearances against NL Central opponents that held a losing record.

Brewers vs Orioles Prediction

Sugano has been solid this season with a 3.08 ERA and 1.03 WHIP, but it doesn’t matter when he pitches for the Orioles. I’ve said for weeks now that the Orioles aren’t a good baseball team, and now they haven’t won a game in 10 days. In two of Sugano’s last three starts, the Orioles didn’t score a single run. The Brewers are putting together a nice week, and Patrick has a 3.35 ERA and 1.28 WHIP on the season. In 28.2 home innings, Patrick has a 2.83 ERA and a .229 allowed batting average. I’m going to continue fading the Orioles, especially when I can get cheap prices like this.