Brewers vs Reds Prediction 6/22/26 MLB Picks Today

In this article, we will formulate a Cubs vs Mets Prediction for this MLB matchup on Monday, June 22^nd in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Cincinnati Reds Preview

The Cincinnati Reds have a 37-39 record this season and are sitting in the 5th place of the NL Central. They have a 19-19 home record and are coming off a 4-1 road win against the Yankees. They will face the Pirates and the Brewers next.

The Reds have a .229 batting average this season, .311 OBP and .395 Slugging percentage. Cincinnati’s pitching staff has a 4.58 ERA and 1.46 WHIP. Elly De La Cruz is the team’s best hitter with a .280 batting average. Sal Stewart leads the team in RBI with 53, adding a team-high 14 home runs.

Brady Singer (R) is the projected starting pitcher for the Reds, and he has a 3-6 record, 5.32 ERA and 1.61 WHIP.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 46-29 record this season and are sitting in the 1st place of the NL Central. They have a 21-14 road record and are coming off a 9-4 road win against the Braves. They will face the Cubs and the Reds next.

The Brewers have a .256 batting average this season, .340 OBP and .394 Slugging percentage. Milwaukee’s pitching staff has a 3.45 ERA and 1.19 WHIP. William Contreras is the team’s best hitter with a .299 batting average. Brice Turang leads the team in RBI with 47, while Jake Bauers adds a team-high 13 home runs.

Brandon Woodruff (R) is the projected starting pitcher for the Brewers, and he has a 2-1 record, 3.60 ERA and 1.03 WHIP.

Milwaukee Brewers @ Cincinnati Reds Betting Trends: June 22, 2026

• Probable Starting Pitcher: Brady Singer      Record this season: 3-6      ERA: 5.32
• Home Record: 3-2
• Last 5 against Brewers: 2-2

Why the Cincinnati Reds will win

• The Brewers have lost each of their last six Monday games as road favorites against NL Central opponents.
• The Reds have won each of their last five Monday games as home underdogs against NL Central opponents.
• The Brewers have failed to cover the run line in 10 of their last 11 games as favorites against the Reds following a win.
• The Reds have covered the run line in eight of their last nine night games against NL Central opponents that held a winning record.
• The Reds have won the first inning in three of their last four home games.
• The Brewers have trailed after 5 innings in each of their last five games against NL Central opponents that held a losing record.
• The Brewers have trailed after 3 innings in four of their last five games against NL Central opponents that held a losing record.

• Probable Starting Pitcher: Brandon Woodruff      Record this season: 2-1      ERA: 3.60
• Road Record: 1-0
• Last 5 against Reds: 4-1

Why the Milwaukee Brewers will win

• The Brewers have won each of their last seven games against NL Central opponents.
• The Reds have lost 13 of their last 14 games against NL Central opponents.
• The Brewers have covered the run line in nine of their last 10 road games against National League opponents.
• The Reds have failed to cover the run line in six of their last seven home games following a win.
• The Brewers have led after 3 innings in each of their last four road games against NL Central opponents.
• The Brewers have won the first inning in three of their last four night games against opponents that held a losing record.
• The Brewers have led after 5 innings in each of their last four games as favorites.

Total Runs Facts

• Each of the Brewers’ last five games against NL Central opponents have gone UNDER the total runs line.
• Five of the Reds’ last six games as underdogs against NL Central opponents have gone OVER the total runs line.
• There has been no run scored during the first inning in nine of the Reds’ last 10 home games against NL Central opponents.
• There has been no run scored during the first inning in six of the Brewers’ last seven night games against NL Central opponents.

Cincinnati Reds Player Prop Facts

• Brady Singer has recorded five or more strikeouts in each of his last four appearances against NL Central opponents that held a winning record.
• Brady Singer has recorded a win in three of his last four appearances with the Reds as home underdogs against NL opponents.
• Elly De La Cruz has recorded at least one hit in each of the Reds’ last nine games as home underdogs against NL Central opponents.
• Elly De La Cruz has hit a home run in three of the Reds’ last four games as home underdogs against NL Central opponents.

Milwaukee Brewers Player Prop Facts

• Brandon Woodruff has recorded six or more strikeouts in each of his last eight appearances with the Brewers as road favorites against NL opponents.
• Sal Frelick has recorded at least one hit in each of his last 12 appearances against NL Central opponents that held a losing record.
• Gary Sanchez has hit a home run in each of his last two appearances against opponents that held a losing record.
• Brandon Woodruff has recorded a win in each of his last six road appearances against NL opponents that held a losing record.
• David Hamilton ranks T10th in the league in Steals (16) this season.

Matchup/League Facts

• The Reds rank 28th in the league for hits this season (584).
• The Reds rank 28th in the league for triples this season (6).
• The Brewers rank 1st in the league for strikeouts this season (736).
• The Brewers rank 2nd in the league for on-base percentage this season (.340).

Brewers vs Reds Prediction

The Reds are 3-1 in their last 4 meetings against the Brewers but are 1-3 in their last 4 meetings in Cincinnati.

In this Brewers vs Reds Prediction, the Brewers are coming as -180 road favorites. I like the Brewers in this one Brandon Woodruff goes up against Brady Singer and his 5.32 ERA and 1.61 WHIP. Woodruff has given up one run or less in three of his last four starts and the Brewers have both a better offense and bullpen, so I expect them to take care of business on the road in this one.