Cardinals vs Astros Prediction 4/16/25 MLB Picks Today

In this article, we will formulate a Cardinals vs Astros prediction for this MLB game on Wednesday, April 16th at Busch Stadium in Saint Louis, Missouri. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 8-9 this year, and they have won three of their last five games. St. Louis won the first game in this series by a score of 8-3, but they lost game two by a score of 2-0. In that shutout loss, the Cardinals pitched very well for most of the game, but did allow two runs later in the game for the loss. St. Louis recorded six hits in the game, and they were led by Nootbaar, who had one hit and one walk in the loss. The Cardinals started Fedde, who allowed six hits and one earned run over 6.0 innings, while Leahy allowed one hit and one earned run over 2.0 innings in relief. 

Prior to this series, the Cardinals won two out of three against the Phillies and lost two out of three against the Pirates. The St. Louis pitching staff has a 4.25 ERA with a 1.18 WHIP and a .225 opponent batting average, while their offense has scored 90 runs with a .282 batting average and a .348 on-base percentage this season. Brendan Donovan has led St. Louis with two home runs and 11 RBIs, while Nolan Arenado has added two home runs and nine RBIs this year. The projected starting pitcher for St. Louis is Steven Matz, who is 0-0 with a 2.31 ERA and a 1.11 WHIP over 11.2 innings pitched this season. 

Houston Astros Betting Preview

The Houston Astros are 8-9 this season, and they have alternated wins and losses over their last 12 games. In their game two win, Houston scored one run in the sixth inning and one in the eighth for a shutout win. The Astros recorded seven hits in the game, and they were led by Alvarez, who went 1-4 with one home run and one RBI in the win. Houston started Brown, who allowed four hits over 6.0 innings for the win, while King, Abreu, and Hader closed out the shutout. 

Prior to this series, the Astros won two out of three against the Angels and lost two out of three against the Mariners. The Houston pitching staff has a 3.75 ERA with a 1.11 WHIP and a .205 opponent batting average, while their offense has scored 65 runs with a .220 batting average and a .308 on-base percentage this season. Isaac Paredes has led Houston with three home runs and nine RBIs, while Yordan Alvarez has added two home runs and 10 RBIs this year. The projected starting pitcher for Houston is Ronel Blanco, who is 1-1 with a 6.94 ERA and a 1.63 WHIP over 11.2 innings pitched this year. 

Why the Cardinals will beat the Astros

• The Astros have lost each of their last seven games as favorites following a win.
• The Cardinals have won each of their last six games as home underdogs following a loss.
• The Astros have failed to cover the run line in each of their last seven games as favorites following a win.
• The Cardinals have covered the run line in 12 of their last 13 games as underdogs following a home loss.
• The Astros have trailed after 5 innings in 14 of their last 16 road games against NL Central opponents that held a losing record.
• The Astros have trailed after 3 innings in each of their last six Wednesday games against NL Central opponents that held a losing record.

Total Runs Facts

• Six of the Cardinals’ last seven day games against AL West opponents have gone OVER the total runs line.
• Five of the Astros’ last six road games against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the Astros’ last 11 games as favorites against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Cardinals’ last seven games.

St. Louis Cardinals Player Prop Facts

• Masyn Winn has scored at least one run in seven of his last eight appearances.
• Nolan Arenado has recorded at least one Double in four of the Cardinals’ last five games against AL opponents that held a losing record.
• Brendan Donovan has recorded at least one Single in each of the Cardinals’ last seven day games against opponents that held a losing record.
• Nolan Arenado has hit a home run in three of his last five home appearances against the Astros after playing the previous day.
• Nolan Arenado has recorded at least one RBI in each of the Cardinals’ last six Wednesday games at Busch Stadium.
• Brendan Donovan has recorded at least one hit in each of the Cardinals’ last 15 games as underdogs.

Houston Astros Player Prop Facts

• Chas McCormick has recorded at least one hit in each of his last 12 appearances in day games against NL teams that held a losing record.
• Jeremy Pena has scored at least one run in each of the Astros’ last five games as road favorites.
• Yordan Alvarez has recorded a Double in three of the Astros’ last four day games against NL opponents that held a losing record.
• Mauricio Dubon has recorded at least one Single in each of his last nine Wednesday appearances.
• Isaac Paredes has hit a home run in three of the Astros’ last five games as favorites.
• Jose Altuve has recorded at least one RBI in each of the Astros’ last four day games.

Cardinals vs Astros Prediction 

Both of these teams have won one game in the series so far, and they will be looking for the series win here. St. Louis did get shut out on Tuesday night, but they do have one of the higher-scoring offenses in the MLB so far this year. Houston has not won back-to-back games so far this season, and Blanco has really struggled through three starts. On the other side, Matz has been very solid out of the bullpen, but this will be his first start of the season. This game is a toss-up in my opinion, but I will stay with the trends and fade Houston after a win. Take the Cardinals here.