Cardinals vs Brewers Prediction 4/27/25 MLB Picks Today

In this article, we will formulate a Cardinals vs Brewers prediction for this MLB game on Sunday, April 27, at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers (13-15, 4-11 Away) are going through a four-game losing skid for the second time this season, and they are hoping to avoid being swept by the St. Louis Cardinals. After losing the series to the Giants on the road, the Brewers lost the opening two of the current series in St. Louis. Minnesota came back from 5-0 down and nearly forced extra innings, but Nolan Arenado’s walk-off homer sealed the win for the Cards. Jackson Chourio led the team with three RBI, while Quinn Priester pitched for 5.0 innings in a no-decision, allowing five runs on eight hits with two strikeouts and three walks. Trevor Megill took the loss.

This season, the Brewers average 4.96 runs per game (5th in the MLB) on a .246/.319/.375 slash line. Regarding pitching, the Brewers’ staff has a 4.20 ERA (19th) and 1.33 WHIP (19th). Jackson Chourio leads the Brewers with a .280 batting average, six home runs, and 23 RBI this season.

The projected starting pitcher for the Brewers is Jose Quintana, who is 3-0 in three starts this season, with a 0.96 ERA and 1.02 WHIP in 18.2 innings.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals (12-15, 10-4 Home) bounced back from their five-game losing skid, during which they were swept by the Mets in four games. The Cards also lost the series to the Braves before defeating the Brewers in the opening two games of the current series. St. Louis blew up a 5-0 lead in Game 2 against Milwaukee, but Nolan Arenado came to the rescue with a walk-off home run to make it 6-5 for the Cardinals. Lars Nootbaar led the offense with two RBI, while Sonny Gray pitched for 6.0 innings in a no-decision, allowing three runs on seven hits with four strikeouts and three walks. Ryan Helsley was credited with the win.

This year, the Cardinals average 4.73 runs per game (7th in the MLB) on a .265/.335/.401 triple-slash. When it comes to pitching, the Cardinals’ staff has a 4.23 ERA (19th) and 1.23 WHIP (12th). Lars Nootbaar leads the Cardinals with a .263 batting average, four home runs, and 17 RBI this season.

Erick Fedde will take the mound for the Cardinals on Sunday. The 32-year-old right-hander has a 1-2 record in five starts this year with a 3.33 ERA and 1.19 WHIP in 27.0 innings.

Why the Brewers will beat the Cardinals

• The Cardinals have lost five of their last six games as home favorites against the Brewers following a win.
• The Brewers have won nine of their last 11 games as road underdogs against NL Central opponents following a loss.
• The Brewers have covered the run line in each of their last 11 games as road underdogs against NL Central opponents following a loss.
• The Cardinals have failed to cover the run line in each of their last six games as home favorites against the Brewers following a win.

Total Runs Facts

• Eight of the Cardinals’ last 10 home games against NL Central opponents have gone UNDER the total runs line.
• Three of the Brewers’ last four games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last 11 games as home favorites against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last six games at Busch Stadium.

Matchup/League Facts

• The Cardinals rank 2nd in the league for hits this season (252).
• The Cardinals are one of only three teams in the league to rank top 10 in both strikeouts and on-base percentage this season.
• The Brewers rank T4th in the league for runs scored this season (139).
• The Brewers rank 5th in the league for hits this season (233).

Cardinals vs Brewers Prediction

The Cardinals won seven of the previous ten H2H encounters, including the last four. The Cards won the opening two games of this series, but I am backing the Brewers to avoid being swept as they start their best pitcher. Quintana is lights out early in the season, but he also has an excellent record against teh Cardinals. He allowed a .091 BA in 55 at-bats against St. Louis, while Quintana posted a 1.13 ERA in 8.0 innings in his last start against the Cardinals. Fedde, on the other hand, allowed a .405 BA in 74 at-bats against the Brewers, while he registered a 5.06 ERA in 10.2 innings in two starts against Milwaukee last year. I believe the visitors have the pitching advantage here, and I am backing them to win.