Cardinals vs Brewers Prediction 9/27/26 MLB Picks Today

In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB matchup on Sunday, September 27^th in the final game of the regular season. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 102-59 record this season and are sitting in the 1st place of the NL Central. They have a 54-26 home record and are coming off a 3-2 home win against the Cardinals.

The Milwaukee Brewers have a .258 batting average this season, .341 OBP and .403 Slugging percentage. Milwaukee’s pitching staff has a 3.51 ERA and 1.18 WHIP. Jackson Chourio is the team’s best hitter with a .288 batting average. Brice Turang leads the team in RBI with 99, while Jake Bauers adds a team-high 26 home runs.

Jacob Misiorowski (R) is the projected starting pitcher for the Brewers, and he has a 15-5 record, 1.86 ERA and 0.80 WHIP.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 77-84 record this season and are sitting in the 4th place of the NL Central. They have a 39-41 away record and are coming off a 2-3 road loss against the Brewers.

The St. Louis Cardinals have a .240 batting average this season, .313 OBP and .379 Slugging percentage. St. Louis’s pitching staff has a 4.25 ERA and 1.36 WHIP. Alec Burleson is the team’s best hitter with a .279 batting average, adding a team-high 116 RBI. Jordan Walker adds a team-high 29 home runs.

Andre Pallante (R) is the projected starting pitcher for the Cardinals, and he has a 12-8 record, 3.61 ERA and 1.24 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 27, 2026

• Probable Starting Pitcher: Jacob Misiorowski      Record this season: 15-5      ERA: 1.86
• Home Record: 7-1
• Last 5 against Cardinals: 3-1

Why the Milwaukee Brewers will win

• The Brewers have won each of their last seven games after playing the previous day.
• The Cardinals have lost eight of their last nine games at American Family Field.
• The Brewers have covered the run line in five of their last six games after playing the previous day.
• The Brewers have led after 5 innings in each of their last seven home games against NL Central opponents that held a losing record.
• The Brewers have led after 3 innings in five of their last six home games.
• The Brewers have won the first inning in 12 of their last 15 home games against opponents that held a losing record.

• Probable Starting Pitcher: Andre Pallante      Record this season: 12-8      ERA: 3.61
• Road Record: 7-1
• Last 5 against Brewers: 0-4

Why the St. Louis Cardinals will win

• The Brewers have lost four of their last five Sunday games as favorites.
• The Brewers have failed to cover the run line in each of their last six day games against the Cardinals following a win.
• The Cardinals have covered the run line in 12 of their last 14 games as underdogs after playing the previous day.
• The Cardinals have led after 5 innings in seven of their last eight road day games.
• The Cardinals have won the first inning in three of their last four day games against NL opponents that held a winning record.

Total Runs Facts

• Five of the Cardinals’ last six games have gone UNDER the total runs line.
• Five of the last six games between the Cardinals and Brewers at American Family Field have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of Jacob Misiorowski’s last four appearances as a starter against the Cardinals.
• There has been at least one run scored in the first inning in six of the Cardinals’ last seven day games against NL Central opponents.

Milwaukee Brewers Player Prop Facts

• Jake Bauers has hit a home run in each of his last two appearances in day games against teams that held a losing record.
• Jacob Misiorowski has recorded nine or more strikeouts in each of his last four appearances in day games against teams that held a losing record.
• William Contreras has recorded at least one hit in each of his last 12 appearances against opponents that held a losing record.
• Jacob Misiorowski ranks 1st amongst qualified players for Earned Run Average (1.86) this season.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has recorded at least one hit in each of the Cardinals’ last nine Sunday games as underdogs.
• Andre Pallante has recorded a win in seven of his last nine appearances with the Cardinals as road underdogs.
• Alec Burleson has hit a home run in each of the Cardinals’ last three games.

Matchup/League Facts

• The Brewers rank 1st in the league for hits this season (1412).
• The Brewers rank 1st in the league for on-base percentage this season (.341).
• The Cardinals rank 28th in the league for triples this season (14).
• The Cardinals rank 28th in the league for slugging percentage this season (.379).

Cardinals vs Brewers Prediction

The Brewers are 9-1 in their last 10 meetings against the Cardinals and have won their last 5 meetings in Milwaukee.

In this Cardinals vs Brewers Prediction, the Brewers are coming as -225 home favorites. The Brewers are heading in the playoffs and will put Jacob Misiorowski on the mound, probably for a few innings, but I still expect them to win, as they have been unstoppable lately, with a 7-1 record in their last 8 games. Pallante has been in good form but has been torched by the Brewers this season and the Cardinals average just 3 runs in their last 10 games. Take the Brewers on the runline.