Cardinals vs Brewers Prediction 9/21/25 MLB Picks Today

The Milwaukee Brewers and St. Louis Cardinals meet Sunday in MLB action at Busch Stadium. Here’s a Cardinals vs Brewers Prediction. This article will include a Cardinals vs Brewers Pick.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 95-60 on the year and play the Padres and Reds next. The Milwaukee Brewers are batting .261 on the season, have a .334 OBP, and a .409 slugging percentage. The Milwaukee Brewers pitching staff has a 3.61 ERA and a 1.23 WHIP. Brice Turang leads the Milwaukee Brewers with 161 hits and 77 RBI, while Sal Frelick and William Contreras have combined for 296 hits and 138 RBI.

Freddy Peralta gets the ball for the Milwaukee Brewers, and he is 17-6 with a 2.65 ERA and 195 strikeouts this season. Peralta is 5-6 with a 4.67 ERA and 91 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 75-80 on the year and play the Giants and Cubs next. The St. Louis Cardinals are batting .246 on the season, have a .315 OBP, and a .378 slugging percentage. The St. Louis Cardinals pitching staff has a 4.25 ERA and a 1.32 WHIP. Alec Burleson leads the St. Louis Cardinals with 137 hits and 86 RBI while Brendan Donovan and Willson Contreras have combined for 253 hits and 128 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 7-12 with a 4.30 ERA and 116 strikeouts this season. Liberatore is 3-0 with a 1.14 ERA and 25 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers @ St. Louis Cardinals Betting Trends: September 21, 2025

• Probable Starting Pitcher: Matthew Liberatore      Record this season: 7-12      ERA: 4.30
• Home Record: 5-5
• Last 5 against Brewers: 1-0

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last five games following a home loss.
• The Brewers have lost six of their last seven games at Busch Stadium after going to extra innings.
• The Brewers have failed to cover the run line in each of their last seven games against the Cardinals following a win.
• The Cardinals have covered the run line in seven of their last eight games against the Brewers.
• The Cardinals have led after 3 innings in three of their last four games.
• The Brewers have trailed after 5 innings in each of their last five road games.
• The Cardinals have won the first inning in three of their last four games.

• Probable Starting Pitcher: Freddy Peralta      Record this season: 17-6      ERA: 2.65
• Road Record: 8-5
• Last 5 against Cardinals: 2-0

Why the Milwaukee Brewers will win

• The Brewers have won 11 of their last 12 road games against teams that held a losing record.
• The Cardinals have lost four of their last five day games at Busch Stadium following a loss.
• The Cardinals have failed to cover the run line in each of their last seven Sunday day home games.
• The Brewers have covered the run line in each of their last five road games following an extra innings win.
• The Brewers have led after 3 innings in five of their last six day games against NL Central opponents that held a losing record.
• The Brewers have led after 5 innings in five of their last six day games against NL Central opponents that held a losing record.

Total Runs Facts

• Seven of the Cardinals’ last eight home games after playing the previous day have gone UNDER the total runs line.
• Four of the Brewers’ last five road games after going to extra innings have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Cardinals’ last six day games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Brewers’ last nine games at Busch Stadium.

St. Louis Cardinals Player Prop Facts

• Nolan Arenado has hit a home run in five of his last 13 home appearances against the Brewers after playing the previous day.
• Brendan Donovan has recorded at least one hit in each of his last 11 appearances against the Brewers.
• Brendan Donovan has recorded a Double in three of the Cardinals’ last four home games against the Brewers.

Milwaukee Brewers Player Prop Facts

• Sal Frelick has recorded at least one hit in each of his last 12 appearances against NL Central opponents.
• Andrew Vaughn has recorded a Double in each of his last three appearances.
• Freddy Peralta has recorded a win in each of his last five road appearances against NL opponents.
• Sal Frelick has hit a home run in two of his last three appearances.

Matchup/League Facts

• The Cardinals rank 30th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1151).
• The Brewers rank 2nd in the league for hits this season (1378).
• The Brewers rank 2nd in the league for batting average this season (.261).

Cardinals vs Brewers Prediction

The Cardinals continue to have issues stringing together solid performances, and Liberatore has allowed 22 hits and 10 earned runs in his last 20.1 innings. The Brewers are making a push for the best record in baseball, and Peralta has been money this season with his 2.65 ERA and 1.07 WHIP. Peralta has allowed 21 hits and 7 runs in his last 44 innings. Just elite stuff we’re seeing from Peralta. Give me the Brewers as they inch closer to home field throughout the MLB playoffs.