Cardinals vs Padres Prediction 8/1/25 MLB Picks Today

In this article, we will formulate a Cardinals vs Padres Prediction for this MLB game on Friday, August 1^st at the Petco Park in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have a 60-49 record this season and are sitting in second place in the NL West. They have a 34-18 home record, and are 44-62 in over/under. The Padres are coming off a 5-0 home victory over the Mets and have five consecutive wins. Under is 7-3 in their last 10 games, and they are playing the Red Sox and the Diamondbacks next.

The Padres have a .250 batting average this season, a .318 OBP, and a .380 Slugging percentage. San Diego’s pitching staff has a 3.55 ERA and 1.22 WHIP.  Manny Machado leads the Padres with 127 hits, adding a team-high .302 batting average and a team-high 71 RBI. He also adds a team-high 20 home runs.

Nick Pivetta (R) will take the mound for the Padres, and he has a 10-3 record, 2.81 ERA, and 0.99 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 55-55 record this season and are sitting in 4^th place in the NL Central. The Cardinals have a 23-31 road record and are 55-49 in over/under. They are coming off a 0-2 home defeat by the Marlins, and are 1-4 in their last 5 games. Under is 4-1-1 in their last 6 games and are playing the Dodgers and the Cubs next.

The Cardinals have a .250 batting average this season, a .320 OBP, and a .389 Slugging percentage. Saint Louis’ pitching staff has a 4.17 ERA and 1.28 WHIP. Brendan Donovan leads the Cardinals with 111 hits, while Alec Burleson is the team’s best hitter with a .287 batting average. Wilson Contreras leads the team in RBI, with 61, adding a team-high 14 home runs.

Matthew Liberatore (R) is the projected starting pitcher for the Cardinals, and he has a 6-8 record, 4.04 ERA, and 1.27 WHIP.

Why the San Diego Padres will win

• The Cardinals have lost 12 of their last 13 road games against National League opponents following a home loss.
• The Padres have won each of their last five games.
• The Padres have covered the run line in each of their last five games against National League opponents following a home win.
• The Cardinals have failed to cover the run line in six of their last seven road games.
• The Cardinals have lost the first inning in three of their last four games as underdogs against National League opponents.
• The Cardinals have trailed after 3 innings in each of their last seven road games.
• The Cardinals have trailed after 5 innings in each of their last seven games at Petco Park against National League opponents that held a winning record.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last six night games against NL West opponents following a loss.
• The Padres have lost four of their last five games as favorites following a home win.
• The Cardinals have covered the run line in 14 of their last 15 night games against NL West opponents following a loss.
• The Padres have failed to cover the run line in 13 of their last 14 games as favorites following a win.
• The Padres have trailed after 3 innings in each of their last four games as favorites against NL Central opponents.
• The Padres have trailed after 5 innings in each of their last four games as favorites against NL Central opponents.

Total Runs Facts

• Five of the Cardinals’ last six games as underdogs against NL West opponents have gone UNDER the total runs line.
• Four of the Padres’ last five home games against NL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Padres’ last eight games as home favorites against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last five night games.

Matchup/League Facts

• The Padres rank 1st in the league for hits allowed this season (812).
• The Padres rank 2nd in the league for opponent batting average this season (.227).
• The Cardinals rank 30th in the league for triples this season (4).
• The Cardinals rank 29th in the league for strikeouts this season (800).

Cardinals vs Padres Prediction

The Cardinals are 4-2 in their last 6 overall meetings against the Padres, and under is 4-2 in their last 6 meetings.

In this Cardinals vs Padres Prediction, the Padres are coming as -162 home favorites. The Padres are rightfully favored, as they have a better overall record, and they have been one of the best home teams in the whole league. San Diego has been red-hot lately, and Pivetta has been excellent this season, and even better at home, with a 2.07 home ERA. He has been in great form lately, with a 1.17 ERA across his last 5 starts, and the Padres have the best bullpen in the majors to back him up. Keep it simple and take the San Diego Padres to take care of business at home in this one.