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Cubs vs Orioles Prediction 8-2-25 MLB Picks

Baltimore Orioles (50-60) vs. Chicago Cubs (64-45)
August 2, 2025 2:20 pm EDT
The Line: Chicago Cubs -207 / Baltimore Orioles +168; Over/Under: 8
(Get latest betting odds)

The Baltimore Orioles and the Chicago Cubs meet Saturday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cubs vs Orioles Prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Tomoyuki Sugano for the start here, and Sugano is 8-5 with a 4.38 ERA and 71 strikeouts this season. This will be Sugano’s first career start against the Cubs. Matthew Boyd is slated to start for the Cubs and is 11-4 with a 2.47 ERA and 110 strikeouts this season. In his last five starts against the Orioles, Boyd is 1-1 with a 6.20 ERA and 24 strikeouts.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to rebound from a 1-0 loss at the hands of the Cubs on Friday to sit at 50-60 on the year. After this series, the Orioles will head on the road for a series against the Philadelphia Phillies.

Orioles Drop Back-To-Back Games

Adley Rutschman has 59 hits with 12 doubles, 8 homers, and 25 RBIs. Jackson Holliday has 105 hits with 15 doubles, 2 triples, 14 homers, and 43 RBIs. Ryan Mountcastle has 46 hits with 13 doubles, 2 homers, and 15 RBI, and Gunnar Henderson has a team-high 101 strikeouts as well this season. Heston Kjerstad added 4 homers and 19 RBIs while Jordan Westburg has 12 home runs and 26 RBIs this season.

Why the Baltimore Orioles will win

  • The Orioles have won each of their last three games as underdogs after playing the previous day.
  • The Cubs have lost three of their last four games as favorites following a home win.
  • The Cubs have failed to cover the run line in each of their last seven day games against AL East opponents following a home win.
  • The Orioles have covered the run line in each of their last seven games as underdogs against National League opponents.

Baltimore Orioles Player Prop Facts

  • Colton Cowser has recorded at least one hit in 13 of his last 14 appearances against NL opponents that held a winning record.
  • Adley Rutschman has recorded at least one Double in each of the Orioles’ last three games as underdogs.
  • Gary Sanchez has hit a home run in four of his last five road appearances against NL Central opponents that held a winning record.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their win over Baltimore to start the series to climb to 64-45 this season. After this series, the Chicago Cubs will have a divisional series against the Cincinnati Reds at home.

Cubs Win Back-To-Back Matchups

Ian Happ has 88 hits with 17 doubles, 15 home runs, and 51 RBIs. Kyle Tucker has 108 hits, including 21 doubles, 4 triples, 18 home runs, and 61 RBIs, while Seiya Suzuki also has 103 hits with 25 doubles and 26 home runs and 81 RBIs of his own. Pete Crow-Armstrong also has contributed 113 hits, 30 doubles, 4 triples, 27 home runs, and 78 RBIs this season. Dansby Swanson has added 16 home runs and 51 RBIs, while also having 123 strikeouts, and Suzuki has 124 strikeouts so far this season. Crow-Armstrong also has a team-high 29 stolen bases, while Nico Hoerner has 19 stolen bases this season. Tucker’s also added 23 stolen bases while Michael Busch has also chipped in 15 doubles, 3 triples, 21 home runs, and 61 RBIs this season.

Why the Chicago Cubs will win

  • The Cubs have won eight of their last nine day games against AL East opponents that held a losing record.
  • The Orioles have lost six of their last seven road games against NL Central opponents.
  • The Cubs have covered the run line in each of their last seven Saturday games against American League opponents.
  • The Orioles have failed to cover the run line in seven of their last eight Saturday day games against teams that held a winning record.

Chicago Cubs Player Prop Facts

  • Ian Happ has hit a home run in three of the Cubs’ last five home games against AL East opponents that held a losing record.
  • Matthew Boyd has recorded seven or more strikeouts in four of his last five appearances against AL East opponents that held a losing record.
  • Matthew Boyd has recorded a win in nine of his last 10 home appearances.
  • Justin Turner has recorded at least one hit in each of his last 10 home appearances against the Orioles.

Total Runs Facts

  • Nine of the Cubs’ last 10 day games against AL East opponents have gone UNDER the total runs line.
  • Five of the Orioles’ last six day games against National League opponents have gone UNDER the total runs line.

Cubs vs Orioles Prediction

I’m on the Cubs here. Initially, I was on the Cubs before I saw it was Matthew Boyd pitching, but after seeing that, I’m inclined to side with the Cubs as Boyd has pitched really well at home this season. He just got caught in a bad spot against the Milwaukee Brewers. The Orioles started to show signs of the effects that all of their recent trades would have, getting shut out on Friday, and I think Boyd could have another strong start here. Give me the Cubs.

Chris Ruffolo's Free Pick: Chicago Cubs -207

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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