Cubs vs Mets Prediction 9/25/25 MLB Picks Today
NY Mets (81-77) vs. Chicago Cubs (89-69)
September 25, 2025 7:40 pm EDT
The Line: Chicago Cubs -110 / NY Mets -110; Over/Under: 7.5
(Get latest betting odds)
The New York Mets and the Chicago Cubs meet Thursday in MLB action from Citi Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cubs vs Mets Prediction.
Starting Pitching Matchup
The New York Mets will send out Nolan McLean for the start here and McLean is 4-1 with a 1.27 ERA and 46 strikeouts this season. This will be McLean’s first career start against the Cubs. Shota Imanaga will get the start for the Cubs here and is 9-7 with a 3.37 ERA and 114 strikeouts this season. In his career, Imanaga is 1-1 with a 9.00 ERA and 10 strikeouts against the Mets.
New York Mets Recap
The New York Mets will be looking to rebound from their 10-3 loss at the hands of the Cubs in Wednesday’s matchup to sit at 81-77 this season. After this series, the Mets will head on the road for a division series against the Miami Marlins.
Mets Looking To Salvage Rubber Match
Pete Alonso has 164 hits with 38 doubles, 37 home runs, 122 RBIs and a .274 batting average while Juan Soto has 148 hits with 20 doubles, 35 stolen bases, 42 home runs and 104 RBIs on the year. Francisco Lindor has 166 hits with 31 stolen bases along with 34 doubles, 28 home runs and 80 RBIs while Mark Vientos has 17 home runs and 60 RBIs, but also has 109 strikeouts so far this season. Brandon Nimmo has also added 146 hits with 27 doubles and 24 home runs and 88 RBIs this season. Luis Torrens has also chipped in 14 doubles and Luisangel Acuna has 15 stolen bases as well this season.
Why the New York Mets will win
- The Mets have won each of their last nine games against the Cubs following a loss.
- The Cubs have lost each of their last eight games against the Mets following a win.
- The Cubs have failed to cover the run line in each of their last six home games against NL East opponents following a win.
- The Mets have covered the run line in each of their last six night games against the Cubs following a loss.
New York Mets Player Prop Facts
- Juan Soto has hit a home run in four of the Mets’ last five night games against NL Central opponents that held a winning record.
- Juan Soto has recorded at least one hit in each of the Mets’ last 14 road games against NL Central opponents.
Chicago Cubs Recap
The Chicago Cubs come into this game looking to build on their win over the Mets from Wednesday’s matchup to sit at 89-69 this season. After this series, the Cubs will take on the St. Louis Cardinals in a series at home.
Cubs Snap Five-Game Skid
Ian Happ has 132 hits with 29 doubles, 23 home runs and 74 RBIs. Kyle Tucker has 132 hits including 25 doubles, 4 triples, 22 home runs and 73 RBIs while Seiya Suzuki also has 133 hits with 30 doubles and 27 home runs and 91 RBIs of his own. Pete Crow-Armstrong also has contributed 140 hits, 37 doubles, 4 triples, 29 home runs and 90 RBIs as well this season. Dansby Swanson has added 23 home runs and 76 RBIs, while also having 165 strikeouts and Suzuki has 159 strikeouts so far this season. Crow-Armstrong also has a team-high 35 stolen bases while Nico Hoerner has 28 stolen bases this season. Tucker’s also added 25 stolen bases while Michael Busch has also chipped in 22 doubles, 4 triples, 30 home runs and 82 RBIs this season.
Why the Chicago Cubs will win
- The Mets have lost each of their last eight road games after playing the previous day.
- The home team has won five of the Cubs’ last six games.
- The Cubs have covered the run line in each of their last seven games following a win.
- The Mets have failed to cover the run line in seven of their last eight road games after playing the previous day.
Chicago Cubs Player Prop Facts
- Shota Imanaga has recorded five or more strikeouts in each of his last four home appearances against opponents that held a winning record.
- Kyle Tucker has hit a home run in five of his last nine appearances in night games against NL East teams that held a winning record.
- Ian Happ has recorded at least one Double in five of the Cubs’ last six home games against NL East opponents that held a winning record.
- Nico Hoerner has recorded at least one hit in each of the Cubs’ last eight home games.
- Shota Imanaga has recorded a win in four of his last five appearances against NL East opponents.
Total Runs Facts
- Each of the Mets’ last eight night games against National League opponents have gone OVER the total runs line.
- Five of the Cubs’ last six home games have gone OVER the total runs line.
Cubs vs Mets Prediction
I’m on the under here. This is just a solid matchup between the best arms in their respective rotations. McLean’s been every bit as good as advertised so far for the Mets this season, while Imanaga can easily go 6 or 7 shutout innings on any given night. I think we have a bit of a duel brewing here, so give me the under.