White Sox vs Orioles Prediction 9/16/25 MLB Picks Today

The Baltimore Orioles and the Chicago White Sox meet Tuesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a White Sox vs Orioles Prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Dean Kremer for the start here and Kremer is 9-10 with a 4.43 ERA and 132 strikeouts this season. In his career, Kremer is 2-0 with a 1.02 ERA and 16 strikeouts against the Whie Sox. Shane Smith will get the nod for the White Sox here and is 6-7 with a 3.78 ERA and 122 strikeouts this season. This will be Smith’s first career start against the Orioles. 

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to build on their 4-1 win over the White Sox from Monday’s opener to sit at 70-80 this season. After this series, the Orioles will have a division series at home against the New York Yankees.

Orioles Snap Three-Game Losing Streak

Adley Rutschman has 70 hits with 16 doubles, 9 homers and 29 RBIs. Jackson Holliday has 138 hits with 20 doubles, 3 triples, 17 homers and 55 RBIs. Gunnar Henderson has 143 hits with 32 doubles, 5 triples, 16 home runs and 62 RBIs with 23 stolen bases and 128 strikeouts while Holliday has a team-high 130 strikeouts as well this season. 

Why the Baltimore Orioles will win

• The Orioles have won each of their last six road games against the White Sox.
• The White Sox have lost five of their last six games as favorites.
• The Orioles have covered the run line in each of their last eight games as road underdogs against the White Sox following a win.
• The White Sox have failed to cover the run line in each of their last six games as favorites.

Baltimore Orioles Player Prop Facts

• Tyler O’Neill has hit a home run in three of his last four appearances against opponents that held a losing record.
• Dean Kremer has recorded six or more strikeouts in each of his last five appearances with the Orioles as underdogs against AL opponents.
• Ryan Mountcastle has recorded at least one hit in each of his last 10 road appearances against AL opponents that held a losing record.
• Adley Rutschman has recorded a Double in three of his four previous appearances with the Orioles as road underdogs against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from their series opening loss to Baltimore last time out to sit at 57-94 this season. After this series, the White Sox will welcome the San Diego Padres to town for an interleague series.

White Sox Drop 4th Straight

Lenyn Sosa has 126 hits including 18 doubles, 20 home runs and 68 RBIs. Andrew Benintendi has 100 hits including 16 doubles, 19 home runs, 60 RBIs and a .241 batting average while Miguel Vargas has 107 hits, 31 doubles, 14 home runs and 53 RBIs. Brooks Baldwin has also added 31 RBIs while Luis Robert Jr. has a team-high 33 stolen bases along with 53 RBIs so far this season. Chase Meidroth has added 108 hits with 13 stolen bases as well as 15 doubles this season.

Why the Chicago White Sox will win

• The Orioles have lost each of their last eight games as underdogs against American League opponents.
• The home team has won six of the Orioles’ last seven games.
• The Orioles have failed to cover the run line each of their last nine Tuesday games against teams that held a losing record.
• The White Sox have covered the run line in eight of their last nine games against teams that held a losing record.

Chicago White Sox Player Prop Facts

• Luis Robert has recorded at least one hit in 18 of his last 19 appearances against opponents that held a losing record.
• Luis Robert has hit a home run in three of his last seven appearances with the White Sox as favorites.

Total Runs Facts

• Each of the White Sox’s last five games have gone UNDER the total runs line.
• Each of the Orioles’ last five night games against American League opponents have gone UNDER the total runs line.

White Sox vs Orioles Prediction

I’m taking a shot on the White Sox here. Kremer has been far less effective on the road compared to his marks at home. The White Sox, despite their recent issues, have actually been a fairly solid team at home as of late. I think Chicago gets the job done in this one to get some revenge on Tuesday, so give me Chicago here.