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Chicago White Sox vs Boston Red Sox 5/25/22 MLB Picks, Predictions, Odds

Boston Red Sox (20-22) vs. Chicago White Sox (21-21)
May 25, 2022 8:10 pm EDT
The Line: Chicago White Sox -169 / Boston Red Sox +150; Over/Under: -8.5
(Get latest betting odds)

The Boston Red Sox and Chicago White Sox meet Wednesday in MLB action at Guaranteed Rate Field. The Boston Red Sox look to build on their six-game winning streak. The Chicago White Sox look for a win after splitting their last 10 games.

The Boston Red Sox have scored 30 runs in their last three games and four or more runs in eight straight games. The Red Sox have won 10 of their last 11 games when scoring four or more runs. Rafael Devers leads the Red Sox with 59 hits and 25 RBI, while Xander Bogaerts and JD Martinez have combined for 99 hits and 38 RBI. Rich Hill gets the ball, and he is 1-1 with a 3.90 ERA and 23 strikeouts this season. Hill is 0-2 with a 6.26 ERA and 22 strikeouts in his career against the White Sox.


The Chicago White Sox have scored 11 runs in their last three games and three or fewer runs in five of their last eight games. The White Sox have won six of their last 10 games when scoring three or fewer runs. Tim Anderson leads the White Sox with 54 hits and 19 RBI, while Luis Robert and Jose Abreu have combined for 73 hits and 36 RBI. Lucas Giolito gets the ball, and he is 2-1 with a 2.84 ERA and 44 strikeouts this season. Giolito is 0-1 with a 7.00 ERA and 22 strikeouts in his career against the Red Sox.

The Red Sox are 5-1 in their last 6 games as an underdog and 6-0 in their last 6 overall. The White Sox are 1-4 in their last 5 home games and 4-1 in their last 5 games following a loss. The over is 5-0 in Red Sox last 5 overall. The under is 8-3 in White Sox last 11 overall. The Red Sox are 5-2 in the last 7 meetings in Chicago and 1-4 in the last 5 meetings.

The Chicago White Sox should be favored with Lucas Giolito on the mound, as he has a 2.84 ERA through 31.2 innings and has a 2.77 ERA at home. Rich Hill is hit or miss, and he’s not the most attractive option at 42 years old. However, we’re getting big plus money with one of the hotter teams in the league and an offense that’s averaging 10 runs in their last three tries. The Red Sox are red-hot right now. Give me the plus money.

Randy Chambers's Free Pick: Boston Red Sox +150

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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