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Chicago White Sox vs Toronto Blue Jays Prediction 4/5/26 MLB Picks Today

Toronto Blue Jays (4-4) vs. Chicago White Sox (3-5)
April 5, 2026 2:10 pm EDT
The Line: Chicago White Sox +135 / Toronto Blue Jays -163; Over/Under: 8
(Get latest betting odds)

The Toronto Blue Jays and the Chicago White Sox meet Sunday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Toronto Blue Jays vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Toronto Blue Jays will send out Eric Lauer for the start here and is 1-0 with a 3.38 ERA and 9 strikeouts this season. This will be Lauer’s second career start against the White Sox. The Chicago White Sox will start Davis Martin here and Martin is 1-0 with a 5.40 ERA and 6 strikeouts this season. This will be Martin’s first career start against the Blue Jays.

Toronto Blue Jays Recap

The Toronto Blue Jays come into this game looking to bounce back from their 6-3 loss at the hands of the White Sox last time out to sit at 4-4 this season. After this series, the Blue Jays will head home for a series against the Los Angeles Dodgers in a World Series rematch.

Blue Jays Drop Three In A Row

Entering Saturday, Andres Gimenez leads the Blue Jays with 9 hits with a triple, 2 home runs and 7 RBIs while Ernie Clement has 9 hits with 3 doubles and 2 RBIs. Kazuma Okamoto has 7 hits with 2 home runs, 3 RBIs and a team-high 15 strikeouts while George Springer also has 2 homers with 3 RBIs. Vladimir Guerrero Jr. has 7 hits with a pair of RBIs as well. 

Why the Toronto Blue Jays will win

  • The White Sox have lost five of their last six games following a win.
  • The Blue Jays have won five of their last six day games against the White Sox following a road loss.
  • The Blue Jays have covered the run line in each of their last seven Sunday day games.
  • The White Sox have failed to cover the run line in five of their last six games against American League opponents after playing the previous day.

Toronto Blue Jays Player Prop Facts

  • Vladimir Guerrero Jr. has hit a home run in three of the Blue Jays’ last four road games.
  • Eric Lauer has recorded six or more strikeouts in each of his four previous appearances in day games against AL Central teams that held a losing record.
  • Alejandro Kirk has recorded at least one hit in each of his last eight appearances in day games against teams that held a losing record.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to add on to their win over Toronto on Saturday to sit at 3-5 on the year. After this series, the White Sox will take on the Baltimore Orioles at home.

White Sox Win Back-To-Back Games

Going into Saturday, Munetaka Murakami has 6 hits with 3 home runs and 4 RBIs while Miguel Vargas has a home run and 6 RBIs while Austin Hays and Colson Montgomery each have a home run and 5 RBIs and Tristan Peters has a team-high 7 hits so far this season.

Why the Chicago White Sox will win

  • The Blue Jays have lost seven of their last eight games as road favorites.
  • The underdogs have won four of the Blue Jays’ last five games.
  • The Blue Jays have failed to cover the run line in 14 of their last 15 games as road favorites against American League opponents.
  • The White Sox have covered the run line in each of their last eight home games against American League opponents following a win.

Chicago White Sox Player Prop Facts

  • Austin Hays has hit a home run in three of his last eight appearances with his team as a home underdog against AL opponents.
  • Austin Hays has recorded at least one hit in each of his last 12 appearances with his team as a home underdog against the Blue Jays.
  • Munetaka Murakami ranks 3rd in the league in Home Runs (4) this season.

Total Runs Facts

  • Each of the White Sox’s last six games have gone OVER the total runs line.
  • Eight of the Blue Jays’ last nine games against AL Central opponents have gone OVER the total runs line.

Toronto Blue Jays vs. Chicago White Sox Prediction

I’m on Toronto here. I know it’s not an attractive look with Toronto right now, considering the fact that the Jays have been dropping games against one of the weakest schedules in the league to start the year. However, the Jays are still loaded offensively, and I think these losses are just giving us line value with Toronto as this line would be far more hefty had the Jays won on Saturday. I still think the Jays are the far better team and we’re just getting a cheaper price with them here. Give me Toronto.

Chris Ruffolo's Free Pick: Toronto Blue Jays -163

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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