Cleveland Guardians vs Chicago White Sox Prediction 9/13/25 MLB Picks Today

The Chicago White Sox and the Cleveland Guardians meet Saturday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Davis Martin for the start here and Martin is 6-9 with a 4.03 ERA and 92 strikeouts this season. In his career, Martin is 1-2 with a 7.71 ERA and 9 strikeouts against Cleveland. Parker Messick will get the nod for the Guardians here and is 2-0 with a 1.93 ERA and 18 strikeouts this season. This will be Messick’s first career start against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound from a 4-0 loss at the hands of the Guardians in Friday’s series opener to sit at 57-91 this season. After this series, the White Sox will head home for a series against the Baltimore Orioles.

White Sox Have Two-Game Win Streak Snapped

Lenyn Sosa has 121 hits including 17 doubles, 20 home runs and 65 RBIs. Andrew Benintendi has 98 hits including 16 doubles, 18 home runs, 58 RBIs and a .247 batting average while Miguel Vargas has 104 hits, 30 doubles, 14 home runs and 52 RBIs. Brooks Baldwin has also added 31 RBIs while Luis Robert Jr. has a team-high 33 stolen bases along with 53 RBIs so far this season. Chase Meidroth has added 101 hits with 13 stolen bases as well as 15 doubles this season.

Why the Chicago White Sox will win

• The White Sox have won nine of their last 11 games as underdogs after playing the previous day.
• The Guardians have lost three of their last four Saturday games as home favorites.
• The White Sox have covered the run line in each of their last four night games at Progressive Field following a loss.
• The Guardians have failed to cover the run line in six of their last seven night games against the White Sox at Progressive Field following a home win.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit a home run in each of his last two appearances after playing the previous day.
• Luis Robert has recorded at least one hit in 15 of his last 16 road appearances.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their win over the White Sox from Friday’s opener to sit at 76-71 this season. After this series, the Guardians will head on the road for an important division series against the Detroit Tigers.

Guardians Win 8 Of Their Last 10

Steven Kwan has 152 hits as part of a .275 batting average and 10 home runs, 25 doubles and 48 RBIs. Kyle Manzardo has 97 hits with 15 doubles, 2 triples, 25 home runs and 65 RBIs as well this year. Gabriel Arias has 20 doubles but also 139 strikeouts and Manzardo has 119 strikeouts so far this season. Arias has also added 10 home runs and 48 RBIs and Jose Ramirez has chipped in 28 home runs and 76 RBIs with 37 stolen bases as well. Carlos Santana has also added 89 hits with 11 home runs and 52 RBIs as well this season.

Why the Cleveland Guardians will win

• The White Sox have lost each of their last 12 night games against AL Central opponents following a road loss.
• The Guardians have won eight of their last nine night games against AL Central opponents.
• The White Sox have failed to cover the run line each of their last 11 Saturday night games against teams that held a winning record.
• The Guardians have covered the run line in seven of their last eight games.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in two of the Guardians’ last three home games against AL Central opponents that held a losing record.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Will Brennan has recorded at least one hit in each of his last six appearances with the Guardians as favorites against AL opponents.
• Jose Ramirez ranks T3rd in the league in Steals (37) this season.

Total Runs Facts

• Each of the Guardians’ last four games have gone UNDER the total runs line.

Chicago White Sox vs. Cleveland Guardians Prediction

I’m going to take a shot on the White Sox here. I was burned with the White Sox in Friday’s opener, but I think this is still a solid White Sox lineup that just fell flat in the opener. Cleveland’s been playing well in their own right as has Parker Messick, but the value for me in this game is on the White Sox here. Give me the White Sox in this one.