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Cubs vs Cardinals Prediction 8/16/26 MLB Picks Today

St. Louis Cardinals (62-61) vs. Chicago Cubs (72-52)
August 16, 2026 3:00 pm EDT
The Line: Chicago Cubs -162 / St. Louis Cardinals 134; Over/Under: 9
(Get latest betting odds)

The St. Louis Cardinals and Chicago Cubs meet Sunday in MLB action at Wrigley Field. Here’s a Cubs vs Cardinals Prediction. This article will include a Cubs vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 62-61 on the year and play the Phillies and Reds next. The St. Louis Cardinals are batting .239 on the season, with a .315 OBP and a .380 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.04 ERA and a 1.34 WHIP. Alec Burleson leads the St. Louis Cardinals with 132 hits and 86 RBI, while Jordan Walker and Ivan Herrera have combined for 243 hits and 135 RBI.

Hunter Dobbins gets the ball for the St. Louis Cardinals, and he is 2-3 with a 3.40 ERA and 42 strikeouts this season. Dobbins is 0-0 with a 5.00 ERA and 8 strikeouts in his career against the Chicago Cubs.

Chicago Cubs Betting Preview

The Chicago Cubs are 72-52 on the year and play the White Sox and Mariners next. The Chicago Cubs are batting .249 on the season, with a .338 OBP and a .417 slugging percentage. The Chicago Cubs’ pitching staff has a 4.10 ERA and a 1.25 WHIP. Pete Crow-Armstrong leads the Chicago Cubs with 130 hits and 73 RBI, while Alex Bregman and Nico Hoerner have combined for 246 hits and 117 RBI.

Edward Cabrera gets the ball for the Chicago Cubs, and he is 5-4 with a 5.10 ERA and 65 strikeouts this season. Cabrera is 0-2 with a 3.52 ERA and 16 strikeouts in his career against the St. Louis Cardinals.

Why the Chicago Cubs will win

  • The Cubs have won each of their last 10 games following a loss.
  • The Cardinals have lost seven of their last eight day games following a win.
  • The Cubs have covered the run line in each of their last six games following a loss.
  • The Cardinals have failed to cover the run line in seven of their last eight day games following a win.

Why the St. Louis Cardinals will win

  • The Cardinals have won four of their last five games as underdogs after playing the previous day.
  • The Cubs have lost five of their last seven games as home favorites against NL Central opponents.
  • The Cardinals have covered the run line in seven of their last eight games as underdogs after playing the previous day.
  • The Cubs have failed to cover the run line in seven of their last eight games against NL Central opponents following a home loss.
  • The Cardinals have led after 5 innings in four of their last five day games.
  • The Cardinals have led after 3 innings in six of their last eight day games against National League opponents.

Total Runs Facts

  • Nine of the Cardinals’ last 11 road games have gone UNDER the total runs line.
  • Three of the last four games between the Cardinals and Cubs have gone UNDER the total runs line.
  • There has been no run scored during the first inning in each of Hunter Dobbins’ last four appearances as a starter.
  • There has been at least one run scored in the first inning in 11 of the Cubs’ last 13 games as home favorites.

Chicago Cubs Player Prop Facts

  • Edward Cabrera has recorded five or more strikeouts in each of his last seven Sunday appearances against NL teams that held a winning record.
  • Nico Hoerner has recorded at least one hit in each of the Cubs’ last 10 games against NL Central opponents that held a winning record.
  • Miguel Amaya has hit a home run in each of his last two appearances against the Cardinals after playing the previous day.
  • Pete Crow-Armstrong ranks 5th in the league in Steals (30) this season.

St. Louis Cardinals Player Prop Facts

  • Jimmy Crooks has hit a home run in two of his last three road appearances against opponents that held a winning record.
  • Hunter Dobbins has recorded four or more strikeouts in each of his last nine appearances.
  • Blaze Jordan has recorded at least one hit in each of his last 10 appearances with the Cardinals as road underdogs.
  • Alec Burleson ranks T8th in the league in Hits (132) this season.

Matchup/League Facts

  • The Cubs rank 1st in the league for on-base percentage this season (.338).
  • The Cubs rank 1st in the league for walks this season (526).
  • The Cardinals rank 28th in the league for doubles this season (171).
  • The Cardinals rank T3rd in the league for home runs allowed this season (120).

Cubs vs Cardinals Prediction

We’re getting plus money with a Cardinals team that’s had success on the road and is fighting for their playoff lives. Dobbins has been respectable through 45 frames with a 3.40 ERA and 1.31 WHIP. Cabrera has been disappointing in his first season with the Cubs, as he has a 5.10 ERA and 1.40 WHIP, and he hasn’t pitched in over a month due to a hamstring injury. Decent-sized favorite for what? The Cards at this price have to be one of the better value bets on Sunday’s MLB card.

Randy Chambers's Free Pick: St. Louis Cardinals 134

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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