Cubs vs Guardians Game 2 Prediction 4/5/26 MLB Picks Today

In this article, we will formulate a Cubs vs Guardians Game 2 Prediction for this MLB matchup on Sunday, April 5^th in the third game of this series and the second of today’s double-header. Let’s take a look at the prediction for this MLB matchup.

Cleveland Guardians Preview

The Guardians have a 5-3 record this season and are sitting in the first place of the AL Central. They have a 1-0 home record and are coming off a 4-1 home win over the Cubs. Their previous three games were a 4-1 road win, a 1-4 road loss and a 4-2 road win to the Dodgers.

The Guardians have a .203 batting average this season, .287 OBP and .348 Slugging percentage. Cleveland’s pitching staff has a 3.60 ERA and 1.21 WHIP. Chase DeLauter is the team’s best hitter with a .346 batting average, also leading the team in RBI with 8 and adding a team-high 5 home runs.

Parker Messick (L) is the projected starting pitcher for the Guardians, and he has a 1-0 record, 0.00 ERA and 0.83 WHIP.

Chicago Cubs Preview

The Cubs have a 3-4 record this season and are sitting in the last place of the NL Central. They have a 0-1 road record and are coming off a 1-4 road loss to the Guardians. Their previous three games were a 6-2 home win, a 0-2 home loss and a 7-2 home win over the Angels.

Chicago has a .222 batting average this season, .315 OBP and .342 Slugging percentage. Chicago’s pitching staff has a 3.63 ERA and 1.16 WHIP. Nico Hoerner is the team’s best hitter with a .292 batting average. Ian Happ leads the team in RBI with 5, also adding a team-high 3 home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 0-1 record, 7.20 ERA and 1.60 WHIP.

The Chicago Cubs @ Cleveland Guardians Betting Trends: April 5, 2026: Game 2

• Probable Starting Pitcher: Parker Messick      Record this season: 1-0      ERA: 0.00
• Home Record: 0-0
• Last 5 against Cubs: –

• Probable Starting Pitcher: Shota Imanaga      Record this season: 0-1      ERA: 7.20
• Road Record: 0-0
• Last 5 against Guardians: 1-0

Cleveland Guardians Player Prop Facts

• Chase DeLauter ranks T1st in the league in Home Runs (5) this season.

Chicago Cubs Player Prop Facts

• Nico Hoerner ranks T1st in the league in Steals (4) this season.

Cubs vs Guardians Game 2 Prediction

The Cubs are 3-1 in their last 4 head-to-head matches against the Guardians but the Guardians have won their last four head-to-head home matches.

In this Cubs vs Guardians Prediction, the Cubs are coming as -124 road favorites. This will be the second game of the double-header and the outcome is pretty much connected to the first game. Imanaga had a rough season start for the Cubs, while Messick had a shutout start against the Dodgers and the Guardians are far better against left-handed pitching, so I like them as home dogs in this spot. Take the Guardians on the moneyline for plus money, especially if they have lost the first game earlier today.