Cubs vs Padres Prediction 4/29/26 MLB Picks Today

In this article, we will formulate a Cubs vs Padres Prediction for this MLB matchup on Wednesday, April 29^th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have a 19-10 record this season and are sitting in the second place of the NL West. They have a 10-5 home record and are coming off a 3-8 home loss against the Cubs. Their previous three games were a 9-7 home win against the Cubs, a 7-12 loss and a 6-4 win at home against the Diamondbacks.

The Padres have a .238 batting average this season, .312 OBP and .386 Slugging percentage. San Diego’s pitching staff has a 4.20 ERA and 1.30 WHIP. Xander Bogaerts is the team’s best hitter with a .286 batting average. Ramon Laureano leads the team in RBI with 18, and Xander Bogaerts adds a team‑high 5 home runs.

Matt Waldron (R) is the projected starting pitcher for the Padres, and he has a 0-1 record, 12.46 ERA and 2.31 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 18-12 record this season and are sitting in the second place of the NL Central. They have a 7-7 away record and are coming off an 8-3 road win against the Padres. Their previous three games were a 7-9 road loss against the Padres, a 0-6 and a 4-12 road loss against the Dodgers.

The Cubs have a .261 batting average this season, .353 OBP and .424 Slugging percentage. Chicago’s pitching staff has a 4.01 ERA and 1.20 WHIP. Nico Hoerner is the team’s best hitter with a .293 batting average, also leading the team in RBI with 26. Ian Happ adds a team‑high 7 home runs.

Jameson Taillon (R) is the projected starting pitcher for the Cubs, and he has a 1-1 record, 4.55 ERA and 1.30 WHIP.

The Chicago Cubs @ San Diego Padres Betting Trends: April 29, 2026

• Probable Starting Pitcher: Matt Waldron      Record this season: 0-1      ERA: 12.46
• Home Record: 0-0
• Last 5 against Cubs: –

Why the San Diego Padres will win

• The Padres have won each of their last nine day games against NL Central opponents following a home loss.
• The Cubs have lost each of their last seven road games against the Padres following a win.
• The Padres have covered the run line in 17 of their last 18 day games against National League opponents following a loss.
• The Cubs have failed to cover the run line in each of their last eight games as road favorites against NL West opponents following a win.
• The Cubs have trailed after 3 innings in each of their last six Wednesday games against NL West opponents that held a winning record.
• The Cubs have trailed after 5 innings in nine of their last 10 road games against National League opponents that held a winning record.
• The Padres have won the first inning in three of their last four day games at Petco Park.

• Probable Starting Pitcher: Jameson Taillon      Record this season: 1-1      ERA: 4.55
• Road Record: 0-1
• Last 5 against Padres: 1-0

Why the Chicago Cubs will win

• The Cubs have won each of their last eight games as favorites.
• The favorites have covered the run line in each of the last five games between the Cubs and Padres.
• The Padres have failed to cover the run line in four of their last five games as underdogs against NL Central opponents.
• The Padres have trailed after 3 innings in five of their last six games.
• The Cubs have led after 5 innings in seven of their last eight Wednesday games against opponents that held a winning record.

Total Runs Facts

• Seven of the Cubs’ last eight games have gone OVER the total runs line.
• Each of the Padres’ last four home games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last 10 games as underdogs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Cubs’ last nine games at Petco Park.

San Diego Padres Player Prop Facts

• Xander Bogaerts has recorded at least one hit in each of the Padres’ last nine games against NL Central opponents.
• Luis Campusano has hit a home run in three of his last four appearances against NL opponents.
• Fernando Tatis Jr. ranks T10th in the league in Steals (7) this season.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit a home run in five of the Cubs’ last eight games.
• Jameson Taillon has recorded a win in five of his last six appearances with the Cubs as road favorites.
• Jameson Taillon has recorded five or more strikeouts in six of his last seven appearances with his team as a favorite against NL West opponents.
• Seiya Suzuki has recorded at least one hit in each of the Cubs’ last six games against the Padres.
• Nico Hoerner ranks T7th in the league in Hits (36) this season.

Matchup/League Facts

• The Padres rank T1st in the league for home runs allowed this season (23).
• The Padres rank T5th in the league for doubles this season (54).
• The Cubs rank 1st in the league for on-base percentage this season (.353).
• The Cubs rank 2nd in the league for walks this season (136).

Cubs vs Padres Prediction

Both teams are tied 5-5 in their last 10 meetings and are 2-2 in their last 4 meetings in San Diego.

In this Cubs vs Padres Prediction, the Cubs are coming as -115 road favorites. Both teams have split wins in this series in two high-scoring affairs with 16 and 11 total runs. Both pitchers in today’s matchup have been bad with a combined 17.01 ERA, with Taillon having given up 4+ runs in two of his last three starts and Waldron having given up 12 runs in his two starts. Chicago has the third-best offense in baseball and the Padres are better against righties, so I expect another high-scoring affair. Take the over 9 in this one.