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Cubs vs Padres Prediction 6/29/26 MLB Picks Today

San Diego Padres (43-39) vs. Chicago Cubs (46-38)
June 29, 2026 8:05 pm EDT
The Line: Chicago Cubs -156 / San Diego Padres 129; Over/Under: 11.5
(Get latest betting odds)

In this article we will formulate a Cubs vs Padres prediction for this MLB game on Monday, June 29th at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 46-38 this season after they won two out of three against the Brewers by scores of 2-6, 8-2, and 4-3. In game three, Chicago tied the game in the seventh inning and they scored three runs in the 10th, before barely getting the win. The Cubs recorded four hits and they committed one error in the game, while they were led by Suzuki, who went 1-5 with two RBIs. Wilson allowed four hits and zero earned runs over 4.1 innings, while Webb got the win and Wicks picked up the save.  Prior to that series, Chicago swept the Mets in four games and split two games with the Blue Jays. 

This season, Chicago has a 4.24 ERA with a 1.25 WHIP and a .239 opponent batting average, while they have scored 413 runs with a .240 batting average and a .335 on base percentage. Michael Busch has led the Cubs with nine home runs and 45 RBIs, while Ian Happ has added 17 home runs and 41 RBIs. The projected starting pitcher for Chicago is Shota Imanaga, who is 5-6 with a 4.40 ERA and a 1.05 WHIP over 92.0 innings pitched this season. 

San Diego Padres Betting Preview

The San Diego Padres are 43-39 this year after they lost two out of three against the Dodgers by scores of 7-1, 3-15, and 2-4. In game three, San Diego cut the deficit to 4-2 in the sixth inning, but couldn’t find anymore offense in the loss. The Padres recorded six hits in the game and they were led by Machado, who went 2-4 with one home run and one RBI. King allowed three hits and four earned runs over 4.1 innings for the loss, while Peralta pitched two scoreless innings in relief. Prior to that series, San Diego swept the Braves in three games, but lost two out of three against the Rangers before that. 

This season, San Diego has a 3.89 ERA with a 1.30 WHIP and a .242 opponent batting average, while they have scored 321 runs with a .221 batting average and a .297 on base percentage. Manny Machado has led the Padres with 15 home runs and 44 RBIs, while Gavin Sheets has added 13 home runs and 35 RBIs. The projected starting pitcher for San Diego is TBD. 

Why the Chicago Cubs will win

  • The Cubs have won seven of their last eight games against National League opponents.
  • The Padres have lost seven of their last eight road games against National League opponents.
  • The favorites have covered the run line in six of the Padres’ last seven games at Wrigley Field.
  • The Padres have failed to cover the run line in four of their last five games after playing the previous day.
  • The Padres have trailed after 5 innings in each of their last five road night games.
  • The Cubs have won the first inning in three of their last four games as favorites against NL West opponents.
  • The Cubs have led after 3 innings in each of their last five home games.

Why the San Diego Padres will win

  • The Padres have won each of their last nine night games against the Cubs following a loss.
  • The Cubs have lost each of their last eight night games against the Padres following a win.
  • The Cubs have failed to cover the run line each of their last nine Monday games against teams that held a winning record.
  • The Padres have covered the run line in 13 of their last 14 games as road underdogs following a loss.
  • The Cubs have trailed after 5 innings in each of their last three home games against opponents that held a winning record.
  • The Cubs have trailed after 3 innings in each of their last three home games against opponents that held a winning record.

Total Runs Facts

  • Seven of the Cubs’ last eight night games against NL West opponents have gone UNDER the total runs line.
  • Six of the Padres’ last seven road games against National League opponents have gone UNDER the total runs line.
  • There has been no run scored during the first inning in each of the Padres’ last 13 night games against National League opponents.
  • There has been no run scored during the first inning in 12 of the last 13 night games between the Padres and Cubs.

Chicago Cubs Player Prop Facts

  • Pete Crow-Armstrong has hit a home run in each of the Cubs’ last four games as favorites against NL West opponents.
  • Pete Crow-Armstrong has recorded at least one hit in each of the Cubs’ last 11 home games.

San Diego Padres Player Prop Facts

  • Ty France has hit a home run in each of his last two appearances in night games.
  • Samad Taylor has recorded at least one hit in each of his last eight road appearances.

Matchup/League Facts

  • The Cubs rank 1st in the league for walks this season (373).
  • The Cubs rank 30th in the league for home runs allowed this season (127).
  • The Padres rank 30th in the league for runs scored this season (321).
  • The Padres rank 30th in the league for hits this season (589).

Cubs vs Padres Prediction

Chicago comes into this matchup after winning six of their last seven games and they have allowed three runs or fewer in three of their last four. The Cubs are 23-17 at home this year, while the Padres are 20-18 on the road. San Diego is coming off of a series loss to the Dodgers, but they have scored 5+ runs in three of their last five. The Padres have not announced a starter, while Imanaga has allowed 4+ earned runs in three of his last five outings. It is tough to make a call on this one without a pitcher for the Padres, but I will take the over with the wind blowing out. 

David Racey's Free Pick: Over 11.5

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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