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Cubs vs Rockies Prediction 5/27/25 MLB Picks Today

Colorado Rockies (9-45) vs. Chicago Cubs (33-21)
May 27, 2025 8:05 pm EDT
The Line: Chicago Cubs -340 / Colorado Rockies 270; Over/Under: 0.0001
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In this article, we will formulate a Cubs vs Rockies prediction for this MLB game on Tuesday, May 27, at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

Colorado Rockies Betting Preview

The Colorado Rockies (9-45, 3-23 Away) were swept by the Philadelphia Phillies, lost a series to the New York Yankees, both at home, before opening a road series in Chicago with a loss to the Cubs. In that 3-1 defeat on Monday, Mickey Moniak hit a solo homer as he drove in the only run for the Rox, while Carson Palmquist took the loss after allowing two runs on three hits with four strikeouts and three walks in 5.0 innings.

This year, the Rockies average 3.20 runs per game (29th in the MLB) on a .219/.285/.359 triple-slash. When it comes to pitching, the Rockies’ staff has a 5.67 ERA (30th) and 1.60 WHIP (30th). Hunter Goodman leads the Rockies with a .273 batting average, seven home runs, and 31 RBI this season.

The projected starting pitcher for the Rockies is German Marquez, who is 1-7 in ten starts this season, with a 7.66 ERA and 1.68 WHIP in 47.0 innings.

Chicago Cubs Betting Preview

The Chicago Cubs (33-21, 16-10 Home) won the previous four series, as they beat the Marlins (twice), swept the White Sox, and defeated the Reds. Chicago won eight of the last ten games, including Game 1 of the current series against the Rockies at home. In Monday’s 3-1 victory, Kyle Tucker led the offense with two RBI, while Jameson Taillon got the win after allowing one run on four hits with seven strikeouts and no walks across 6.1 innings of work.

This season, the Cubs average 6.00 runs per game (1st in the MLB) on a .263/.336/.455 triple-slash. When it comes to pitching, the Cubs’ staff has a 4.01 ERA (17th) and 1.29 WHIP (18th). Seiya Suzuki leads the Cubs with a .274 batting average, 14 home runs, and 49 RBI this season.

Cade Horton will take the mound for the Cubs on Tuesday. The 23-year-old right-hander has a 2-0 record in two starts this year with a 4.40 ERA and 1.40 WHIP in 14.1 innings.

Total Runs Facts

  • Six of the Cubs’ last seven night games against NL West opponents have gone OVER the total runs line.
  • Four of the Rockies’ last five games against NL Central opponents have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last 10 games as favorites.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Rockies’ last eight Tuesday night games at Wrigley Field.

Matchup/League Facts

  • The Cubs rank 1st in the league for RBIs this season (316).
  • The Cubs rank 2nd in the league for triples this season (13).
  • The Rockies rank 30th in the league for strikeouts against this season (530).
  • The Rockies rank 30th in the league for ERA this season (5.67).

Cubs vs Rockies Prediction

The Cubs won eight of the previous ten H2H encounters. Despite the teams combined for just four runs in Game 1, seven of Chicago’s last ten games went Over, and I am backing Over in this one because of the starters. German Marquez is playing in a hot and cold form this month; he allowed five runs to the Giants, one to the Padres, five to the D-backs, and one to the Phillies. That said, following a solid outing, I expect Marquez to surrender multiple runs here. I also expect the Rockies to score multiple runs off rookie Cade Horton, who allowed multiple runs in two of his three MLB games so far. Go with Over.

Oliver Zivic's Free Pick: Over 7.5

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Oliver Zivic

Professional journalist and expert bettor with 20+ years of experience. I cover Football (soccer), NFL, NBA, NHL, MLB, CFB, and CBB.

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