Cubs vs White Sox Prediction 5/18/25 MLB Picks Today

The Chicago White Sox and the Chicago Cubs meet Sunday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cubs vs White Sox Prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Jonathan Cannon for the start here, and Cannon is 2-4 with a 3.60 ERA and 39 strikeouts this season. This will be Cannon’s first career start against the Cubs. The Chicago Cubs will trot out Colin Rea for the start here, and Rea is 3-0 with a 2.48 ERA and 29 strikeouts this season. This will be Rea’s first career start against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from a 7-3 loss at the hands of the Cubs last time out to fall to 14-32 on the year. After this series, the White Sox will head home for a series against the Seattle Mariners.

White Sox Lose Three In A Row

Lenyn Sosa leads the White Sox with 40 hits, including 7 doubles and 11 RBIs. Andrew Benintendi has 19 hits, including 5 home runs, 12 RBIs, and a .224 batting average, while Miguel Vargas has a team-high 10 doubles and 17 RBIs. Brooks Baldwin has also added 16 RBIs, while Luis Robert Jr. has a team-high 17 stolen bases along with 17 RBIs so far this season. Andrew Vaughn has 5 home runs and 18 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

• The Cubs have lost each of their last five Sunday games as favorites.
• The White Sox have won three of their last four Sunday games as underdogs.
• The Cubs have failed to cover the run line in each of their last nine Sunday home games against AL Central opponents.
• The White Sox have covered the run line in seven of their last eight Sunday games as underdogs.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit at least one home run in six of his last eight appearances against NL Central opponents that held a winning record.
• Miguel Vargas has recorded at least one RBI in seven of his last eight appearances against NL Central opponents that held a winning record.
• Andrew Vaughn has recorded at least one hit in each of the White Sox’s last 11 Sunday games.
• Austin Slater has recorded a Single in four of his last five appearances against opponents that held a winning record.
• Andrew Benintendi has recorded a Double in each of his five previous appearances at Wrigley Field.
• Andrew Benintendi has scored a run in each of his last five appearances.
• Luis Robert ranks 1st in the league in Steals (17) this season.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to complete the sweep after picking up the W to improve to 27-19 this season. After this series, the Cubs will trek on the road for a series rematch against the Miami Marlins.

Cubs Win Five Of Their Last Seven

Ian Happ has 43 hits with 9 doubles, 3 home runs, and 19 RBIs. Kyle Tucker has 47 hits, including 9 doubles, 4 triples, 10 home runs, and 33 RBIs, while Seiya Suzuki also has 42 hits with 10 doubles and 11 home runs and 37 RBIs of his own. Miguel Amaya added 8 doubles and 20 RBIs, and Pete Crow-Armstrong also has contributed 51 hits, 11 doubles, 12 home runs, and 38 RBIs as well this season. Dansby Swanson has added 10 home runs and 26 RBIs, while Suzuki has the unfortunate distinction of leading the Cubs with 54 strikeouts so far this season. Crow-Armstrong also has a team-high 14 stolen bases, while Nico Hoerner has 10 stolen bases this season. Tucker’s also added 12 stolen bases, while Michael Busch has also chipped in 7 home runs and 24 RBIs this season.

Why the Chicago Cubs will win

• The Cubs have won each of their last eight day games against AL Central opponents.
• The White Sox have lost each of their last eight games against NL Central opponents following a road loss.
• The Cubs have covered the run line in each of their last six day games against AL Central opponents.
• The White Sox have failed to cover the run line each of their last four road games against National League opponents that held a winning record.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit at least one home run in seven of the Cubs’ last 13 games against opponents that held a losing record.
• Seiya Suzuki has recorded at least one Double in three of the Cubs’ last four day games against AL Central opponents that held a losing record.
• Seiya Suzuki has recorded at least one RBI in eight of the Cubs’ last nine games against AL opponents.
• Nico Hoerner has recorded at least one Single in each of the Cubs’ last nine games against AL opponents that held a losing record.
• Seiya Suzuki has recorded at least one hit in each of the Cubs’ last 12 games as favorites against AL opponents.
• Ian Happ has scored a run in each of his last six appearances against AL opponents.
• Pete Crow-Armstrong ranks 5th in the league in Steals (14) this season.

Total Runs Facts

• Eight of the Cubs’ last nine games against American League opponents have gone OVER the total runs line.

Cubs vs White Sox Prediction

I’m on the Cubs here. I want to get on the White Sox, I really do, because there’s going to be value backing them in spots this season. However, this series has not been the spot for the White Sox, as the Cubs are just the better team from Chicago this season. While Jonathan Cannon is a solid option, I just don’t see this as a game where he gets the job done. Colin Rea is far from a world-beater and far from an option I’d lay this kind of price with, but it’s a price that I will back because the Cubs have been the far superior team here. Give me the Cubs -1.5.