Diamondbacks vs Padres Prediction 8-4-25 MLB Picks
San Diego Padres (62-50) vs. Arizona Diamondbacks (53-59)
August 4, 2025 8:40 pm EDT
The Line: Arizona Diamondbacks 118 / San Diego Padres -144; Over/Under: 9.5
(Get latest betting odds)
The San Diego Padres and Arizona Diamondbacks meet Monday in MLB action at Chase Field. Here’s a Diamondbacks vs Padres Prediction. This article will include a Diamondbacks vs Padres Pick.
San Diego Padres Betting Preview
The San Diego Padres are 62-50 on the year and play the Red Sox, Giants, and Dodgers next. The San Diego Padres are batting .251 on the season, have a .319 OBP, and a .381 slugging percentage. The San Diego Padres pitching staff has a 3.56 ERA and a 1.21 WHIP. Manny Machado leads the San Diego Padres with 129 hits and 72 RBI, while Luis Arraez and Fernando Tatis Jr. have combined for 238 hits and 85 RBI.
JP Sears gets the ball for the San Diego Padres, and he is 7-9 with a 4.95 ERA and 97 strikeouts this season. This will be Sears’ second career game against the Arizona Diamondbacks.
Arizona Diamondbacks Betting Preview
The Arizona Diamondbacks are 53-59 on the year and play the Rockies, Rangers, and Rockies next. The Arizona Diamondbacks are batting .249 on the season, have a .324 OBP, and a .435 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.57 ERA and a 1.34 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 113 hits and 75 RBI while Lourdes Gurriel Jr. and Corbin Carroll have combined for 192 hits and 103 RBI.
Brandon Pfaadt gets the ball for the Arizona Diamondbacks, and he is 10-7 with a 5.11 ERA and 98 strikeouts this season. Pfaadt is 2-2 with a 3.24 ERA and 41 strikeouts in his career against the San Diego Padres.
Why the Arizona Diamondbacks will win
- The Padres have lost each of their last four games as road favorites against National League opponents following a win.
- The Diamondbacks have won five of their last six games as underdogs against the Padres.
- The Diamondbacks have covered the run line in each of their last 10 games as underdogs against National League opponents following a road win.
- The Padres have failed to cover the run line in 14 of their last 16 games as favorites following a win.
- The Diamondbacks have won the first inning in four of their last five home games against opponents that held a winning record.
- The Diamondbacks have led after 5 innings in five of their last six home games.
- The Diamondbacks have led after 3 innings in each of their last five games against National League opponents that held a winning record.
Why the San Diego Padres will win
- The Diamondbacks have lost each of their last six games against teams that held a winning record.
- The Padres have won seven of their last eight games.
- The Diamondbacks have failed to cover the run line each of their last six games against teams that held a winning record.
- The road team has covered the run line in five of the last six games between the Padres and Diamondbacks.
- The Diamondbacks have trailed after 3 innings in four of their last five night games.
- The Padres have won the first inning in three of their last four games as road favorites against NL West opponents.
- The Diamondbacks have trailed after 5 innings in four of their last five night games.
Arizona Diamondbacks Player Prop Facts
- Brandon Pfaadt has recorded four or more strikeouts in each of his last eight home appearances against NL West opponents.
- Corbin Carroll has recorded at least one hit in each of his last 11 appearances in night games against NL West teams that held a winning record.
- Gabriel Moreno has hit a home run in three of his last four appearances with the Diamondbacks as underdogs against NL West opponents.
- Brandon Pfaadt has recorded a win in four of his last five appearances with the Diamondbacks as home underdogs.
- Lourdes Gurriel Jr. has recorded at least one Double in three of the Diamondbacks’ last four games as underdogs against NL West opponents.
- Corbin Carroll ranks 9th amongst qualified players for Slugging Percentage (.543) this season.
San Diego Padres Player Prop Facts
- Manny Machado has hit a home run in three of the Padres’ last four Monday games against opponents that held a losing record.
- JP Sears has recorded four or more strikeouts in each of his last seven appearances.
- JP Sears has recorded a win in three of his four previous road appearances against NL West opponents that held a losing record.
- Xander Bogaerts has recorded a Double in four of the Padres’ last five road games against NL West opponents.
- Gavin Sheets has recorded at least one hit in each of the Padres’ last nine road games against NL West opponents.
- Manny Machado ranks T2nd in the league in Hits (129) this season.
Diamondbacks vs Padres Prediction
The Padres would be the play given the week they just had, but I’m looking at the over. Sears has been hittable all season, and he’s allowed 21 hits and 12 earned runs in his last 24.1 innings. Pfaadt has a 5.11 ERA and 1.31 WHIP on the season, and he’s allowed 16 hits and nine runs in his last 10 innings. These are two capable lineups and two pitchers that can get hit hard. I expect a double-digit run total. Give me the over.