Diamondbacks vs Twins Prediction 9/13/25 MLB Picks Today

In this article, we will formulate a Diamondbacks vs Twins Prediction for this MLB game on Saturday, September 13^th at the Target Field the second game of this series, with the Twins having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview

The Minnesota Twins have a 65-82 record this season and are sitting on the 4^th place of the AL Central. The Twins have a 36-36 home record and are 70-68 in over/under. They are coming off a 9-8 home victory over the Dbacks, that ended their two-game losing streak. Over is 7-4 in their last 11 games and are playing the Yankees and the Guardians next.

The Twins have a .239 batting average this season, .313 OBP and .400 Slugging percentage. Minnesota’s pitching staff has a 4.61 ERA and 1.33 WHIP. Trevor Larnach leads the Twins with 119 hits, while Byron Buxton adds team-highs both in RBI, with 76, and in home runs, with 31. He is also the team’s best hitter with a .274 batting average.

Joe Ryan (R) is the projected starter for the Twins, and he has a 13-8 record, 3.32 ERA and 1.01 WHIP.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 73-75 record this season and are sitting on the 4^th place of the NL West. The Diamondbacks have a 34-41 road record and are 71-68 in over/under They are coming off an 8-9 road defeat by the Twins, and have three straight losses. Over is 4-1 in their last 5 games and are playing the Phillies and the Giants next.

The Diamondbacks have a .250 batting average this season, .323 OBP and .434 slugging percentage. Arizona’s pitching staff has a 4.51 ERA and 1.32 WHIP. Geraldo Perdomo leads the Diamondbacks with 154 hits, adding a team-high 95 RBI. He Is also the team’s best hitter with a .285 batting average, while Corbin Carroll leads the team in home runs with 29.

Ryne Nelson (R) is the projected starting pitcher for the Diamondbacks, and he has a 7-3 record, 3.48 ERA and 1.05 WHIP.

Arizona Diamondbacks @ Minnesota Twins Betting Trends: September 13, 2025

• Probable Starting Pitcher: Joe Ryan      Record this season: 13-8      ERA: 3.32
• Home Record: 7-4
• Last 5 against Diamondbacks: 0-0

Why the Minnesota Twins will win

• The Twins have won each of their last nine home games against the Diamondbacks.
• The Diamondbacks have lost each of their last six road games against the Twins following a loss.
• The Diamondbacks have failed to cover the run line in seven of their last eight games against AL Central opponents.
• The Twins have covered the run line in each of their last five games against the Diamondbacks following a home win.
• The Diamondbacks have trailed after 5 innings in seven of their last eight games against AL Central opponents.

• Probable Starting Pitcher: Ryne Nelson      Record this season: 7-3      ERA: 3.48
• Road Record: 2-2
• Last 5 against Twins: 0-2

Why the Arizona Diamondbacks will win

• The Twins have lost each of their last six games as favorites after playing the previous day.
• The Diamondbacks have won five of their last six games as underdogs against American League opponents.
• The underdogs have covered the run line in each of the Twins’ last 11 games.
• The Twins have failed to cover the run line each of their last eight home games against teams that held a losing record.
• The Diamondbacks have led after 3 innings in four of their last five games against American League opponents.
• The Diamondbacks have led after 5 innings in four of their last five games against American League opponents.
• The Diamondbacks have won the first inning in six of their last seven night games against opponents that held a losing record.

Total Runs Facts

• Eight of the Twins’ last nine home games have gone OVER the total runs line.
• Each of the Diamondbacks’ last five games as underdogs against the Twins have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last eight Saturday games against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Diamondbacks’ last seven road games against AL Central opponents.

Minnesota Twins Player Prop Facts

• Joe Ryan has recorded a win in each of his five previous home appearances against NL West opponents.
• Joe Ryan has recorded six or more strikeouts in each of his last four appearances against NL West opponents.
• Ryan Jeffers has recorded a Double in each of his last three appearances in night games against NL West teams that held a losing record.
• Ryan Jeffers has hit at least one home run in three of his last four appearances with the Twins as favorites against the Diamondbacks.
• Ryan Jeffers has recorded at least one hit in each of his last six appearances with the Twins as favorites against NL opponents.
• Byron Buxton ranks 4th amongst qualified players for Slugging Percentage (.565) this season.

Arizona Diamondbacks Player Prop Facts

• Geraldo Perdomo has hit a home run in three of the Diamondbacks’ last four road games against AL opponents.
• Ryne Nelson has recorded five or more strikeouts in each of his last three appearances against AL Central opponents.
• Gabriel Moreno has recorded at least one hit in each of his last 12 appearances in night games against teams that held a losing record.
• Corbin Carroll ranks 6th amongst qualified players for Slugging Percentage (.546) this season.

Matchup/League Facts

• The Twins rank 3rd in the league for walks allowed this season (419).
• The Twins rank 27th in the league for opponent batting average this season (.260).
• The Diamondbacks rank T1st in the league for triples this season (35).
• The Diamondbacks rank 2nd in the league for RBIs this season (712).

Diamondbacks vs Twins Prediction

The Twins are 6-1 in their last 7 head-to-head meetings against the Diamondbacks, having won their last five meetings in Minnesota. Over is 5-1 in their last 6 meetings.

In this Diamondbacks vs Twins Prediction, the Twins are coming as -145 home favorites. The Twins got the win yesterday, but I don’t trust them to get a second straight one, even with Ryan on the mound. He has been struggling lately, having given up 5+ runs in three of his last four starts. On the flip side, Nelson has been weaker on the road for the Dbacks, with a 4.67 road ERA, and both teams have bottom-5 bullpens, and are better against right-handed pitching, averaging 9.6 runs per game against righties. Yesterday’s game had 17 total runs and I like another high-scoring affair today. Take the over 8 runs.