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Diamondbacks vs Yankees Prediction 9/18/26 MLB Picks Today

NY Yankees (88-64) vs. Arizona Diamondbacks (80-73)
September 18, 2026 9:40 pm EDT
The Line: Arizona Diamondbacks 109 / NY Yankees -131; Over/Under: 8
(Get latest betting odds)

The New York Yankees and Arizona Diamondbacks meet Friday in MLB action at Chase Field. Here’s a Diamondbacks vs. Yankees Prediction. This article will include a Diamondbacks vs. Yankees Pick.

New York Yankees Betting Preview

The New York Yankees are 88-64 this year and play the Rays and Orioles next. The New York Yankees are batting .235 on the season, with a .312 OBP and a .409 slugging percentage. The New York Yankees’ pitching staff has a 3.19 ERA and a 1.16 WHIP. Ben Rice leads the New York Yankees with 142 hits and 92 RBI, while Cody Bellinger and Jazz Chisholm Jr. have combined for 236 hits and 126 RBI.

Gerrit Cole gets the ball for the New York Yankees, and he is 8-9 with a 3.67 ERA and 117 strikeouts this season. Cole is 3-2 with a 1.96 ERA and 43 strikeouts in his career against the Arizona Diamondbacks.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 80-73 on the year and play the Rockies and Padres next. The Arizona Diamondbacks are batting .244 on the season, have a .316 OBP, and have a .397 slugging percentage. The Arizona Diamondbacks’ pitching staff has a 4.09 ERA and a 1.28 WHIP. Gabriel Moreno leads the Arizona Diamondbacks with 136 hits and 75 RBI, while Geraldo Perdomo and Ketel Marte have combined for 265 hits and 124 RBI.

Eduardo Rodriguez gets the ball for the Arizona Diamondbacks, and he is 15-6 with a 2.62 ERA and 135 strikeouts this season. Rodriguez is 9-6 with a 2.80 ERA and 120 strikeouts in his career against the New York Yankees.

Why the Arizona Diamondbacks will win

  • The Diamondbacks have won eight of their last nine games as underdogs following a home loss.
  • The Yankees have lost each of their last four Friday night games as favorites against NL West opponents.
  • The underdogs have covered the run line in 10 of the Diamondbacks’ last 11 games.
  • The Yankees have failed to cover the run line each of their last four night games against NL opponents that held a winning record.
  • The Diamondbacks have led after 5 innings in each of their last eight night games at Chase Field against AL East opponents.
  • The Diamondbacks have led after 3 innings in each of their last five home games against AL opponents that held a winning record.

Why the New York Yankees will win

  • The Yankees have won each of their last nine games following a loss.
  • The Diamondbacks have lost each of their last four night games against AL East opponents.
  • The Yankees have covered the run line in each of their last six games following an extra-innings loss.
  • The Diamondbacks have failed to cover the run line in each of their last five games.
  • The Diamondbacks have trailed after 5 innings in each of their last eight night games against opponents that held a winning record.
  • The Yankees have won the first inning in three of their last four games against NL opponents.
  • The Diamondbacks have trailed after 3 innings in each of their last six night games against AL opponents that held a winning record.

Total Runs Facts

  • Each of the Yankees’ last seven road games after going to extra innings have gone UNDER the total runs line.
  • Seven of the Diamondbacks’ last eight games as underdogs have gone UNDER the total runs line.
  • There has been no run scored during the first inning in each of the Diamondbacks’ last six night games against AL opponents.
  • There has been at least one run scored in the first inning in each of the Yankees’ last four games against NL opponents.

Arizona Diamondbacks Player Prop Facts

  • Gabriel Moreno has hit a home run in three of the Diamondbacks’ last four games.
  • Eduardo Rodriguez has recorded five or more strikeouts in six of his last seven appearances with his team as a home underdog against AL East opponents.
  • Nolan Arenado has recorded at least one hit in each of his last 15 appearances against the Yankees.
  • Eduardo Rodriguez has recorded a win in six of his last seven appearances with the Diamondbacks as underdogs.
  • Eduardo Rodriguez ranks T3rd in the league for Wins (15) this season.

New York Yankees Player Prop Facts

  • Aaron Judge has hit at least one home run in four of his last five appearances with the Yankees as road favorites against NL West opponents.
  • Gerrit Cole has recorded six or more strikeouts in 10 of his last 11 appearances with his team as a favorite against NL West opponents.
  • Ryan McMahon has recorded at least one hit in each of his last 15 appearances with his team as a favorite against the Diamondbacks.
  • Gerrit Cole has recorded a win in 10 of his last 12 appearances with his team as a road favorite against NL West opponents.
  • Ben Rice ranks T6th in the league in Home Runs (38) this season.

Matchup/League Facts

  • The Diamondbacks rank T1st in the league for triples this season (36).
  • The Diamondbacks rank 29th in the league for strikeouts this season (1073).
  • The Yankees rank 1st in the league for ERA this season (3.19).
  • The Yankees rank 1st in the league for runs allowed this season (561).

Diamondbacks vs Yankees Prediction

The Yankees are favored because they’re the Yankees, and it doesn’t hurt that Cole is on the mound. However, we’re getting plus money despite the Diamondbacks side that needs a win to stay in the wild card race. Rodriguez has also been one of the best pitchers in baseball with a 2.62 ERA and 1.22 WHIP through 178.1 innings. At home, Rodriguez has a 2.74 ERA and a .232 allowed batting average. The Diamondbacks have won 8 of the last 11 games Rodriguez has pitched. I’m grabbing the more favorable price with the Diamondbacks in what’s a must-win game.

Randy Chambers's Free Pick: Arizona Diamondbacks 109

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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