Giants vs Brewers Prediction 4/22/25 MLB Picks Today

The Milwaukee Brewers and the San Francisco Giants meet Tuesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Giants vs Brewers Prediction.

Starting Pitching Matchup

The Milwaukee Brewers will send Jose Quintana for the start here, and Quintana is 2-0 with a 0.71 ERA and 6 strikeouts this season. In his last five starts against the Giants, Quintana is 1-3 with a 5.06 ERA and 21 strikeouts. Jordan Hicks will get the start for the Giants and is 1-2 with a 6.04 ERA and 19 strikeouts this season. This will be Hicks’ first career start against the Brewers.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to bounce back from a 5-2 loss to start the series in Monday’s matchup. After this series, the Brewers will head on the road for a series against the Cardinals.

Brewers Looking To Even Up Series

Brice Turang has a team-high 28 hits with 3 home runs, 11 RBIs, and 8 stolen bases, while Jackson Chourio has 26 hits with a team-high 8 doubles, 5 home runs, and 19 RBIs, and Sal Frelick has 27 hits as well as 7 stolen bases so far this season. Christian Yelich also has 5 stolen bases with 4 homers and 15 RBIs, while Isaac Collins has added 3 doubles. Chourio also has a team-high 25 strikeouts up to this point in the year. William Contreras has 3 homers and 13 RBIs as well this season.

Why the Milwaukee Brewers will win

• The Giants have lost each of their last seven games against NL Central opponents following a win.
• The Brewers have won five of their last six games as underdogs against National League opponents following a road loss.
• The Giants have failed to cover the run line in eight of their last nine home games against NL Central opponents following a home win.
• The Brewers have covered the run line in each of their last seven Tuesday games as road underdogs.

Milwaukee Brewers Player Prop Facts

• William Contreras has recorded a Single in each of the Brewers’ last eight games against opponents that held a winning record.
• Rhys Hoskins has hit a home run in two of the Brewers’ last three games against opponents that held a winning record.
• William Contreras has recorded at least one RBI in seven of his last eight road appearances against NL West opponents.
• William Contreras has scored at least one run in each of the Brewers’ last six Tuesday night games.
• William Contreras has recorded at least one hit in each of the Brewers’ last nine road games.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to build on Monday’s series-opening win to improve to 15-8 on the year. After this series, the Giants will welcome the Texas Rangers to town.

Giants Looking For Consistency

Jung Hoo Lee leads the Giants with 28 hits, including a team-high 10 doubles along with a pair of triples, 3 home runs, and 15 RBIs with 3 stolen bases, while Heliot Ramos has 21 hits with 7 doubles, 3 home runs, and 9 RBIs. Wilmer Flores also has a team-high 7 home runs and 24 RBIs, while Mike Yastrzemski has 3 home runs with 11 RBIs and 6 doubles, and Tyler Fitzgerald has a team-high 5 stolen bases as well on the year.

Why the San Francisco Giants will win

• The Brewers have lost each of their last four games at Oracle Park against NL West opponents that held a winning record.
• The favorites have won each of the last six games between the Brewers and Giants.
• The favorites have covered the run line in seven of the Brewers’ last eight games.
• The Brewers have failed to cover the run line in six of their last seven games against NL West opponents that held a winning record.

San Francisco Giants Player Prop Facts

• Wilmer Flores has hit a home run in each of the Giants’ last two games as home favorites.
• Wilmer Flores has recorded at least one RBI in each of the Giants’ last four night games against NL teams that held a winning record.
• Heliot Ramos has scored at least one run in each of his last six appearances against NL opponents that held a winning record.
• LaMonte Wade Jr has recorded at least one hit in each of the Giants’ last seven games as favorites against the Brewers.
• LaMonte Wade Jr has recorded at least one Single in each of the Giants’ last six home games against the Brewers.
• Casey Schmitt has recorded a Double in three of his last four home appearances against NL Central opponents.
• Wilmer Flores ranks T5th in the league in Home Runs (7) this season.

Total Runs Facts

• Five of the Giants’ last six games against National League opponents have gone OVER the total runs line.
• Four of the Brewers’ last five games against NL West opponents have gone UNDER the total runs line.

Giants vs Brewers Prediction

I’m on the Brewers here. I get why the Giants would be worth the look at home, but the thing about Jordan Hicks is he’s a flamethrower, but he puts so much behind those pitches. He gases himself far too early in his starts and either gets hit hard or puts a lot of strain on the Giants’ bullpen. Milwaukee has a solid bullpen, and Quintana’s been fantastic out of the gate, and I think the Brewers even up the series here. Give me the Brew Crew on the road.