Giants vs Cardinals Prediction 9/6/25 MLB Picks Today

In this article, we will formulate a Giants vs Cardinals Prediction for this MLB game on Saturday, September 6^th at the Busch Stadium in the second game of this series, with the Giants having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 70-72 record this season and are sitting on the 4^th place of the NL Central. The Cardinals have a 39-34 home record and are 72-62 in over/under. They are coming off a 2-8 home defeat by the Giants, that ended their two-game winning streak. Over is 8-5-1 in their last 14 games and are playing the Brewers and the Mariners next.

The Cardinals have a .246 batting average this season, .314 OBP and .383 Slugging percentage. Saint Louis’ pitching staff has a 4.30 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 123 hits, and he is the team’s best hitter with a .286 batting average. Wilson Contreras leads the team in RBI, with 78, adding a team-high 20 home runs.

Andre Pallante (R) is the projected starting pitcher for the Cardinals, and he has a 6-13 record, 5.38 ERA and 1.44 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 72-69 record this season and are sitting on the third place of the NL West. They have a 37-35 road record and are 67-68 in over/under. They are coming off an 8-2 road victory over the Cardinals, and are 11-1 in their last 12 games. Over is 6-1 in their last 7 games and are playing the Dodgers and the Diamondbacks next.

The Giants have a .239 batting average this season, .315 OBP and .392 Slugging percentage. San Francisco’s pitching staff has a 3.76 ERA and 1.29 WHIP.  Heliot Ramos leads the Giants with 145 hits and is the team’s best hitter, with a .269 batting average. Willy Adames leads the team in RBI with 78, adding a team-high 27 home runs.

Justin Verlander (R) is the projected starting pitcher for the Giants, and he has a 3-10 record, 4.29 ERA and 1.43 WHIP.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last five games as underdogs against National League opponents following a loss.
• The Giants have lost each of their last five games as favorites against the Cardinals following a road win.
• The Cardinals have covered the run line in each of their last six games as underdogs against the Giants.
• The Giants have failed to cover the run line in each of their last five games as favorites against the Cardinals following a road win.
• The Cardinals have led after 3 innings in three of their last four games as home underdogs against National League opponents.
• The Cardinals have led after 5 innings in six of their last eight games against the Giants.

Why the San Francisco Giants will win

• The Giants have won each of their last nine games against National League opponents.
• The Cardinals have lost each of their last four home games against teams that held a winning record.
• The Giants have covered the run line in each of their last seven road games.
• The Cardinals have failed to cover the run line in each of their last six home games against NL West opponents.
• The Giants have won the first inning in eight of their last nine games.
• The Giants have led after 5 innings in five of their last six night games.
• The Giants have led after 3 innings in each of their last six night games.

Total Runs Facts

• Eight of the last nine games between the Giants and Cardinals have gone OVER the total runs line.
• Each of the Giants’ last five night games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Giants’ last nine games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the last nine games between the Giants and Cardinals.

Matchup/League Facts

• The Cardinals rank T29th in the league for triples this season (7).
• The Cardinals rank 29th in the league for strikeouts this season (1050).
• The Giants rank 1st in the league for home runs allowed this season (123).
• The Giants rank 29th in the league for steals this season (63).

Giants vs Cardinals Prediction

The Cardinals are 5-2 in their last 7 head-to-head meetings against the Giants, and are 3-1 in their last 4 meetings in Saint Louis. Over is 8-1 in their last 9 meetings.

In this Giants vs Cardinals Prediction, the Giants are coming as -130 road favorites. I am not interested in backing Verlander as a road favorite, but Pallante has not been better. Both pitchers have a combined 9.67 ERA, with Pallante coming into this matchup in terrible form, having lost his last 5 starts, with a 9.82 ERA in that span. Both pitchers’ home/away splits are even worse, with a combined 11.01 ERA and both teams are better against righties, averaging 9.3 runs per game against right-handed pitching. They are 14-6-1 to the over in their last 21 games combined, and yesterday’s game had 10 total runs. Take the over 8.5 runs in this one.