Giants vs Cubs Prediction 8/27/25 MLB Picks Today

The Chicago Cubs and San Francisco Giants meet Wednesday in MLB action at Oracle Park. Here’s a Giants vs Cubs Prediction. This article will include a Giants vs Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 76-56 on the year and play the Rockies, Braves, and Nationals next. The Chicago Cubs are batting .249 on the season, have a .319 OBP, and a .432 slugging percentage. The Chicago Cubs pitching staff has a 3.77 ERA and a 1.19 WHIP. Nico Hoerner leads the Chicago Cubs with 138 hits and 50 RBI, while Pete Crow-Armstrong and Kyle Tucker have combined for 249 hits and 151 RBI.

Colin Rea gets the ball for the Chicago Cubs, and he is 10-5 with a 3.96 ERA and 93 strikeouts this season. Rea is 1-3 with a 8.31 ERA and 18 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 64-68 on the year and play the Orioles, Rockies, and Cardinals next. The San Francisco Giants are batting .231 on the season, have a .308 OBP, and a .377 slugging percentage. The San Francisco Giants pitching staff has a 3.72 ERA and a 1.28 WHIP. Heliot Ramos leads the San Francisco Giants with 133 hits and 56 RBI while Jung Hoo Lee and Willy Adames have combined for 230 hits and 112 RBI.

Carson Whisenhunt gets the ball for the San Francisco Giants, and he is 1-1 with a 4.91 ERA and 13 strikeouts this season. This will be Whisenhunt’s first career game against the Chicago Cubs.

Why the San Francisco Giants will win

• The Giants have won five of their last six games as underdogs against NL Central opponents.
• The Cubs have lost four of their last five games as road favorites against National League opponents.
• The Cubs have failed to cover the run line in each of their last 16 Wednesday night games as favorites against NL West opponents.
• The Giants have covered the run line in each of their last six games as underdogs against NL Central opponents.
• The Giants have led after 3 innings in five of their last six night games against the Cubs at Oracle Park.
• The Giants have led after 5 innings in five of their last six night games against the Cubs at Oracle Park.

Why the Chicago Cubs will win

• The Giants have lost 14 of their last 15 home games after playing the previous day.
• The Cubs have won each of their last six games against NL West opponents following a road loss.
• The Giants have failed to cover the run line in each of their last 11 home games against National League opponents after playing the previous day.
• The Cubs have covered the run line in nine of their last 10 games as road favorites following a road loss.
• The Giants have trailed after 3 innings in each of their last six Wednesday games as home underdogs.
• The Giants have trailed after 5 innings in each of their last six Wednesday games as home underdogs.

San Francisco Giants Player Prop Facts

• Dominic Smith has recorded at least one hit in each of his last 14 appearances in night games.
• Matt Chapman has hit at least one home run in each of his last two appearances with the Giants as home underdogs against NL opponents.

Chicago Cubs Player Prop Facts

• Ian Happ has recorded a Double in three of his last four appearances with the Cubs as favorites against NL opponents.
• Seiya Suzuki has recorded at least one hit in each of his last 17 appearances in night games against NL West teams that held a losing record.
• Kyle Tucker has hit at least one home run in two of the Cubs’ last three night games against opponents that held a losing record.
• Pete Crow-Armstrong ranks T8th in the league in Steals (31) this season.

Giants vs Cubs Prediction

The Cubs haven’t lost two straight games in a couple of weeks, and Rea has been strong this season. In his last 21.1 innings, Rea has allowed 14 hits and six runs. Whisenhunt has been hit or miss in limited frames, and in nine home innings he has a 7.00 ERA and .270 allowed batting average. We’re not being asked to lay anything crazy. I’ll take the Cubs and the cheap price on the road.