Giants vs Dodgers Prediction 4/21/26 MLB Picks Today

The Los Angeles Dodgers and San Francisco Giants meet Tuesday in MLB action at Oracle Park. Here’s a Giants vs. Dodgers Prediction. This article will include a Giants vs. Dodgers Pick.

Los Angeles Dodgers Betting Preview

The Los Angeles Dodgers are 16-6 on the year and play the Marlins and Cubs next. The Los Angeles Dodgers are batting .293 on the season and have a .366 OBP, and a .507 slugging percentage. The Los Angeles Dodgers pitching staff has a 3.42 ERA and a 1.12 WHIP. Andy Pages leads the Los Angeles Dodgers with 30 hits and 21 RBI, while Freddie Freeman and Max Muncy have combined for 47 hits and 23 RBI.

Yoshinobu Yamamoto gets the ball for the Los Angeles Dodgers, and he is 2-1 with a 2.10 ERA and 21 strikeouts this season. Yamamoto is 0-1 with a 3.03 ERA and 34 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 9-13 on the year and play the Marlins and Phillies next. The San Francisco Giants are batting. 251 on the season, have a .293 OBP, and have a .385 slugging percentage. The San Francisco Giants pitching staff has a 4.15 ERA and a 1.32 WHIP. Matt Chapman leads the San Francisco Giants with 26 hits and 12 RBI while Willy Adames and Luis Arraez have combined for 47 hits and 12 RBI.

Landen Roupp gets the ball for the San Francisco Giants, and he is 3-1 with a 2.38 ERA and 24 strikeouts this season. Roupp is 0-2 with a 7.30 ERA and 15 strikeouts in his career against the Los Angeles Dodgers.

Why the San Francisco Giants will win

• The underdogs have won four of the Giants’ last five games at Oracle Park.
• The Dodgers have lost five of their last six night games at Oracle Park following a win.
• The Giants have covered the run line in each of their last six games as home underdogs following a road loss.
• The Dodgers have failed to cover the run line in five of their last six night games at Oracle Park following a win.
• The Giants have won the first inning in five of their last six night games against NL West opponents that held a winning record.
• The Giants have led after 3 innings in each of their last five night games against NL West opponents.
• The Giants have led after 5 innings in five of their last six games against NL West opponents.

Why the Los Angeles Dodgers will win

• The Dodgers have won 14 of their last 15 night games against teams that held a losing record.
• The Giants have lost eight of their last nine night games against teams that held a winning record.
• The Giants have failed to cover the run line in six of their last seven home games against NL West opponents that held a winning record.
• The Dodgers have covered the run line in five of their last six games against National League opponents following a road win.
• The Dodgers have led after 3 innings in seven of their last eight road games against NL West opponents.
• The Dodgers have led after 5 innings in eight of their last nine road games against NL West opponents.

Total Runs Facts

• Each of the Giants’ last four games as underdogs against National League opponents has gone UNDER the total runs line.
• Three of the Dodgers’ last four games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Giants’ last eight home games against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Dodgers’ last four night games against NL West opponents.

San Francisco Giants Player Prop Facts

• Luis Arraez has recorded at least one hit in each of his last 10 appearances in night games against teams that held a winning record.
• Heliot Ramos has hit a home run in two of the Giants’ last three games.

Los Angeles Dodgers Player Prop Facts

• Freddie Freeman has recorded at least one hit in each of his last 15 road appearances against NL opponents.
• Mookie Betts has hit a home run in four of his last six appearances in night games against teams that held a losing record.

Matchup/League Facts

• The Giants rank 30th in the league for steals this season (5).
• The Giants rank 30th in the league for walks this season (43).
• The Dodgers rank 1st in the league for runs scored this season (133).
• The Dodgers rank 1st in the league for hits this season (222).

Giants vs Dodgers Prediction

The Giants have shown signs of life over these last few days but they’ve struggled to put it together overall this season. I doubt there’s much success against Yamamoto and his 2.10 ERA and 0.82 WHIP. Yes, this is a rivalry where both teams usually show up, but the Dodgers have the edge in most spots and there’s a pitching advantage here as well.

Roupp has been a solid pitcher through 30 career starts and he has a 0.97 WHIP through 22.2 innings this season. Still, the Dodgers have been far and away the more consistent team up to this point. I’ll roll with the Dodgers and lay the RL to shave down the price.