Giants vs Padres Prediction 8/20/25 MLB Picks Today

In this article, we will formulate a Giants vs Padres Prediction for this MLB game on Wednesday, August 20^th at the Petco Park in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have a 70-56 record this season and are sitting on the second place of the NL West. They have a 39-21 home record, and are 51-71 in over/under. The Padres are coming off a 5-1 home victory over the Giants, which ended their four-game losing streak. Under is 6-1-1 in their last 8 games and are playing the Dodgers and the Mariners next.

The Padres have a .251 batting average this season, .322 OBP and .382 Slugging percentage. San Diego’s pitching staff has a 3.55 ERA and 1.20 WHIP. Luis Arraez leads the Padres with 142 hits and team-high .292 batting average. Manny Machado leads the team in RBI, with 73, adding a team-high 20 home runs.

JP Sears (L) is the projected starting pitcher for the Padres, and he has a 7-10 record, 5.12 ERA and 1.31 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 61-65 record this season and are sitting on the third place of the NL West. They have a 31-32 road record and are 57-64 in over/under. They are coming off a 1-5 home defeat by the Padres, that ended their two-game winning streak. Under is 8-3-1 in their last 12 games and are playing the Cubs and the Brewers next.

The Giants have a .232 batting average this season, .309 OBP and .375 Slugging percentage. San Francisco’s pitching staff has a 3.68 ERA and 1.28 WHIP.  Heliot Ramos leads the Giants with 128 hits and is the team’s best hitter, with a .265 batting average. Wilmer Flores leads the team in RBI with 63, while Willy Adames adds a team-high 19 home runs.

Landen Roupp (R) is the projected starting pitcher for the Giants, and he has a 7-6 record, 3.45 ERA and 1.45 WHIP.

Why the San Diego Padres will win

• The Padres have won eight of their last nine games against the Giants following a win.
• The Giants have lost eight of their last nine games against the Padres following a loss.
• The Padres have covered the run line in seven of their last eight home games following a home win.
• The Giants have failed to cover the run line in seven of their last eight games against NL West opponents following a loss.
• The Giants have trailed after 3 innings in seven of their last eight Wednesday games against NL West opponents that held a winning record.
• The Padres have led after 5 innings in four of their last five games as favorites.

Why the San Francisco Giants will win

• The Giants have won four of their last five games as road underdogs against National League opponents following a loss.
• The Padres have lost each of their last three games as favorites against NL West opponents following a home win.
• The Padres have failed to cover the run line in each of their last seven Wednesday night games as favorites against National League opponents.
• The Giants have covered the run line in each of their last four road games against National League opponents following a loss.
• The Padres have lost the first inning in three of their last four games against NL West opponents.
• The Giants have led after 3 innings in five of their last six road night games.
• The Giants have led after 5 innings in five of their last six road night games.

Total Runs Facts

• Each of the Padres’ last seven night games against NL West opponents have gone UNDER the total runs line.
• Each of the Giants’ last five night games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last eight night games at Petco Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last four games.

Matchup/League Facts

• The Padres rank 1st in the league for opponent batting average this season (.225).
• The Padres rank 1st in the league for hits allowed this season (927).
• The Giants rank 1st in the league for home runs allowed this season (108).
• The Giants rank T29th in the league for steals this season (56).

Giants vs Padres Prediction

The Padres are 9-3 in their last 12 meetings against the Giants, and are 3-1 in their last 4 visits in San Diego. Under is 7-2 in their last 9 meetings.

In this Giants vs Padres Prediction, the Padres are coming as -160 home favorites. I don’t trust either pitcher, as Sears has only played one game for the Padres before going to the IL, and he was torched for 5 earned runs. He has also been weaker at home this season, with a 5.48 home ERA, while Roupp has been also weaker on the road for the Giants, with a 4.15 road ERA. Roupp had three straight quality starts before getting torched by the Rays in his last start, and his previous start against the Padres this season was a shutout. I don’t love it, but I like the chances with the Giants as road dogs in this one. Lean towards the San Francisco Giants and the plus money in this one.