Guardians vs Athletics Prediction 6/21/25 MLB Picks Today

The Cleveland Guardians are visiting the Athletics on Saturday, June 21^st at the Sutter Health Park in the second game of this series, with the Athletics having the 1-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Guardians vs Athletics Prediction. We will examine:

The Athletics recent form and player performance

The Cleveland Guardians recent form and player performance

Recent betting trends and streaks involving the Athletics

Recent betting trends and streaks involving the Cleveland Guardians

Recent betting trends in games played between the Cleveland Guardians vs Athletics

A summary that ties it all together and produces a favorable betting outcome for the Cleveland Guardians vs Athletics game

Athletics Preview

The Athletics have a 32-46 record this season and are sitting on the last place of the AL West. The Athletics have a 15-25 home record and are 43-30 in over/under They are coming off a 5-1 home victory over the Guardians, and are 6-2 in their last 8 games. Over is 3-1 in their last 4 games and are playing the Yankees and the Tigers next.

The Athletics have a .253 batting average this season, .320 OBP and .418 Slugging percentage. Athletics’ pitching staff has a 5.47 ERA and 1.50 WHIP. Jacob Wilson leads the Athletics with 102 hits and a team-high .358 batting average, while Tyler Soderstrom leads the team with 45 RBI, and Brent Rooker adds a team-high 15 home runs.

Mitch Spence (R) is the projected starter for the Athletics, and he has a 2-1 record, 3.50 ERA and 1.24 WHIP. He has been weaker at home, with a 5.25 ERA across 13 home games. He has been excellent in his three starts this season, having given up two runs in 15 innings pitched. This will be his first career start against the Guardians.

Cleveland Guardians Preview

The Cleveland Guardians have a 37-36 record this season and are sitting on the second place of the AL Central. The Guardians have a 18-21 road record and are 33-37 in over/under They are coming off a 1-5 road defeat by the Athletics, and have back-to-back losses. Under is 5-0 in their last 5 games and are playing the Blue Jays and the Giants next.

The Guardians have a .229 batting average this season, .300 OBP and .371 Slugging percentage. Cleveland’s pitching staff has a 3.92 ERA and 1.37 WHIP. Jose Ramirez leads the Guardians with 86 hits and a team-high .317 batting average, while leading the team in home runs, with 13. Carlos Santana leads the team in RBI, with 36.

Logan Allen (R) is the projected starting pitcher for the Guardians, and he has a 5-4 record, 4.21 ERA and 1.48 WHIP. He has a 4.23 ERA across 8 road starts, and he has given up 2+ runs in five of his last six starts. In his only previous start against the A’s back in 2023, he had a shutout performance across four innings pitched.

Why the Athletics will win

• The Athletics have won each of their last five games as underdogs against AL Central opponents.
• The Guardians have lost each of their last six road games against AL West opponents.
• The Guardians have failed to cover the run line each of their last six road games against American League opponents that held a losing record.
• The Athletics have covered the run line in each of their last five games as underdogs against AL Central opponents.
• The Athletics have led after 5 innings in four of their last five games against AL Central opponents.
• The Athletics have won the first inning in three of their last four home games against AL Central opponents.
• The Athletics have led after 3 innings in four of their last five games against AL Central opponents.

Why the Cleveland Guardians will win

• The Guardians have won each of their last six Saturday games against AL West opponents that held a losing record.
• The Athletics have lost 20 of their last 24 night games after playing the previous day.
• The Athletics have failed to cover the run line in five of their last six home games against the Guardians following a win.
• The Guardians have covered the run line in five of their last six road games against the Athletics following a loss.
• The Guardians have led after 3 innings in five of their last six road games against AL West opponents that held a losing record.
• The Guardians have led after 5 innings in four of their last five night games against the Athletics.

Total Runs Facts

• Seven of the Guardians’ last eight road games after playing the previous day have gone UNDER the total runs line.
• Each of the Athletics’ last three games against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Guardians’ last nine games as favorites.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Athletics’ last four games as home underdogs against AL Central opponents.

Matchup/League Facts

• The Athletics rank 30th in the league for walks allowed this season (296).
• The Athletics rank 30th in the league for home runs allowed this season (115).
• The Guardians rank 30th in the league for hits this season (552).
• The Guardians rank 28th in the league for slugging percentage this season (.371).

Guardians vs Athletics Prediction

The Guardians are 9-2 in their last 11 overall meetings against the Athletics, and are 3-2 in their last 5 visits in Oakland. Over is 6-2 in their last 8 meetings.

In this Guardians vs Athletics Prediction, the Guardians are coming as -115 road favorites. Cleveland is rightfully favored, as they have a better overall record, but they have been below average on the road, while the Athletics have not been good at home. The A’s have by far the worst bullpen in the league, but they have a better offense than the Guardians and the pitching advantage today, as Spence looked great in his three starts this season. Allen on the other hand, has been constantly giving up runs, so I like the A’s to keep this one close while those two pitchers are on the mound. Take the Athletics on the moneyline in the first 5 innings.