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Guardians vs Cubs Prediction 7/1/25 MLB Picks Today

Guardians vs Cubs
July 1, 2025 8:05 pm EDT
The Line: Cubs -170 / Guardians +145 / Over/Under: 8
(Get latest betting odds)

The Cleveland Guardians are visiting the Chicago Cubs on Tuesday, July 1st at the Wrigley Field in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Guardians vs Cubs Prediction. We will examine:

The Chicago Cubs’ recent form and player performance

The Cleveland Guardians’ recent form and player performance

Recent betting trends and streaks involving the Chicago Cubs

Recent betting trends and streaks involving the Cleveland Guardians

Recent betting trends in games played between the Cleveland Guardians vs Chicago Cubs

A summary that ties it all together and produces a favorable betting outcome for the Cleveland Guardians vs Chicago Cubs game

Chicago Cubs Preview

The Chicago Cubs have a 49-35 record this season and are sitting in first place in the NL Central. The Cubs have a 25-15 home record and are 42-34 in over/under. They are coming off a 0-2 road defeat by the Astros, and are 3-5 in their last 8 games. Over is 7-3 in their last 10 games, and they are playing the Cardinals and the Twins next.

The Cubs have a .256 batting average this season, a .325 OBP, and a .446 Slugging percentage. Chicago’s pitching staff has a 3.87 ERA and 1.25 WHIP. Kyle Tucker leads the Cubs with 91 hits, while Nico Hoerner is the team’s best hitter with a .293 batting average. Seiya Suzuki leads the team in RBI, with 69, adding a team-high 22 home runs.

Matthew Boyd (L) is the projected starting pitcher for the Cubs, and he has a 7-3 record, 2.65 ERA, and 1.10 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians have a 40-42 record this season and are sitting in second place in the AL Central. The Guardians have a 20-22 road record and are 36-43 in over/under. They are coming off a 0-7 home defeat by the Cardinals and have four consecutive losses. Under is 7-3 in their last 10 games, and they are playing the Tigers and the Astros next.

The Guardians have a .226 batting average this season, a .298 OBP, and a .366 Slugging percentage. Cleveland’s pitching staff has a 4.03 ERA and 1.37 WHIP. Jose Ramirez leads the Guardians with 92 hits and a team-high .309 batting average, while leading the team in home runs, with 13. He also leads the team in RBI, with 38.

Gavin Williams (R) is the projected starting pitcher for the Guardians, and he has a 5-3 record, 3.68 ERA, and 1.43 WHIP.

Why the Chicago Cubs will win

  • The Cubs have won each of their last seven home games against AL Central opponents following a loss.
  • The Guardians have lost nine of their last 10 games against NL Central opponents.
  • The Guardians have failed to cover the run line each of their last six games against teams that held a winning record.
  • The Cubs have covered the run line in seven of their last eight night games against American League opponents following a road loss.
  • The Cubs have led after 5 innings in each of their last four home night games.
  • The Cubs have won the first inning in each of their last four games as favorites against American League opponents.
  • The Cubs have led after 3 innings in each of their last six games as favorites against American League opponents.

Why the Cleveland Guardians will win

  • The Guardians have won four of their last five games as road underdogs following a home loss.
  • The Cubs have lost three of their last four games as home favorites against American League opponents following a road loss.
  • The road team has covered the run line in each of the Guardians’ last eight games.
  • The Cubs have failed to cover the run line in seven of their last eight home games against teams that held a losing record.
  • The Guardians have led after 3 innings in eight of their last 10 night games against the Cubs at Wrigley Field.
  • The Guardians have led after 5 innings in four of their last five games against the Cubs.

Total Runs Facts

  • Each of the Guardians’ last seven road games have gone UNDER the total runs line.
  • Nine of the Cubs’ last 10 home games against American League opponents have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last 10 games between the Guardians and Cubs.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Guardians’ last 10 games at Wrigley Field.

Matchup/League Facts

  • The Cubs rank 2nd in the league for runs scored this season (453).
  • The Cubs rank 2nd in the league for hits this season (745).
  • The Guardians rank 30th in the league for hits this season (603).
  • The Guardians rank T28th in the league for doubles this season (114).

Guardians vs Cubs Prediction

The Guardians are 8-2 in their last 10 overall meetings against the Cubs, and are 3-2 in their last 6 meetings in Chicago. Under is 7-3 in their last 10 meetings.

In this Guardians vs Cubs Prediction, the Cubs are coming as -170 home favorites. The Cubs are rightfully favored, as they have a better overall record and have been strong at home, while the Guardians are below average on the road. The Cubs have the pitching advantage, as Boyd has been sharp this season and in excellent form lately. They also have a better bullpen and the second-best offense in the league, and are even better against right-handed pitching, with 5.7 runs per game. Guardians are weaker against lefties, so this game has Cubs win written all over it.

Nikos Lagouretos's Free Pick: Chicago Cubs -170

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