Guardians vs Mariners Prediction 3/28/26 MLB Picks Today

In this article, we will formulate a Guardians vs Mariners Prediction for this MLB matchup on Saturday, March 28^th. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners have a 1-1 record this season and are sitting in second place of the AL West. They are coming off a 5-1 home win over the Guardians and their previous three games were a 6-4 home loss to the Guardians, a 10-3 road loss to the Padres, and a 4-2 road win over the White Sox in spring training.

The Mariners have a .155 batting average this season, .269 OBP and .534 Slugging percentage. Seattle’s pitching staff has a 3.50 ERA and 1.17 WHIP. Brendan Donovan is the team’s best hitter with a .333 batting average. Luke Raley leads the team in RBI with 3, and Chase DeLauter added a team-high 2 home runs.

Bryan Woo (R) is the projected starting pitcher for the Mariners, and last season he had a 15-7 record, 2.94 ERA and 0.93 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians have a 1-1 record this season and are sitting in second place of the AL Central. They are coming off a 5-1 road defeat by the Mariners and their previous three games were a 6-4 road win over the Mariners, a 10-5 road win over the Diamondbacks, and a 7-0 road win over the Diamondbacks in spring training.

The Guardians have a .235 batting average this season, .307 OBP and .426 Slugging percentage. Cleveland’s pitching staff has a 4.76 ERA and 1.06 WHIP. Rhys Hoskins is the team’s best hitter with a .500 batting average. Chase DeLauter leads the team in RBI with 3, also adding a team-high 3 home runs.

Joey Cantillo (L) is the projected starting pitcher for the Guardians, and last season he had a 3.21 ERA and 1.26 WHIP.

Cleveland Guardians @ Seattle Mariners Betting Trends: March 28, 2026

• Probable Starting Pitcher: Bryan Woo      Record this season: –      ERA: –
• Home Record: –
• Last 5 against Guardians: 0-1

Why the Seattle Mariners will win

• The Mariners have won 10 of their last 11 home games against American League opponents following a home win.
• The Guardians have lost eight of their last nine games against AL West opponents following a road loss.
• The Guardians have failed to cover the run line in six of their last seven games after playing the previous day.
• The Mariners have covered the run line in five of their last six home games against American League opponents after playing the previous day.
• The Mariners have led after 3 innings in four of their last five games against AL Central opponents.
• The Mariners have led after 5 innings in four of their last five night games against AL Central opponents.

• Probable Starting Pitcher: Joey Cantillo      Record this season: –      ERA: –
• Road Record: –
• Last 5 against Mariners: –

Why the Cleveland Guardians will win

• The Guardians have won eight of their last nine games as road underdogs.
• The Mariners have lost six of their last seven games as home favorites.
• The Guardians have covered the run line in 12 of their last 13 games as underdogs.
• The Mariners have failed to cover the run line in each of their last four night games against the Guardians at T-Mobile Park following a win.
• The Mariners have trailed after 3 innings in three of their last four games as favorites.
• The Guardians have won the first inning in three of their last four games against AL West opponents.
• The Guardians have led after 5 innings in six of their last eight road night games.

Total Runs Facts

• Eight of the Guardians’ last nine road games after playing the previous day have gone UNDER the total runs line.
• Five of the Mariners’ last six games as favorites have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Guardians’ last nine games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the last five night games between the Guardians and Mariners.

Seattle Mariners Player Prop Facts

• Brendan Donovan has recorded at least one Double in three of his last four appearances.
• Brendan Donovan has recorded at least one hit in 11 of his last 12 appearances in night games.
• Luke Raley has hit a home run in each of the Mariners’ last two games.
• Cal Raleigh ranked 1st in the league in Home Runs (60) last season.

Cleveland Guardians Player Prop Facts

• Rhys Hoskins has hit a home run in three of his four previous road appearances against the Mariners after playing the previous day.
• Rhys Hoskins has recorded a Double in three of his last four appearances with his team as an underdog against AL opponents.
• Rhys Hoskins has recorded at least one hit in each of his last eight Saturday appearances with his team as an underdog.
• Jose Ramirez ranked T2nd in the league in Steals (44) last season.

Matchup/League Facts

• The Mariners ranked 29th in the league for doubles last season (234).
• The Mariners ranked T29th in the league for triples last season (9).
• The Guardians ranked 30th in the league for hits last season (1199).
• The Guardians ranked 29th in the league for batting average last season (.226).

Guardians vs Mariners Prediction

Both teams are tied 5-5 in their last 10 meetings but the Mariners are 3-1 in their last 4 meetings in Seattle. Under is 3-1 in their last 4 meetings.

In this Guardians vs Mariners Prediction, the Mariners are coming as -190 home favorites. The Mariners bounced back in the second game of the series with a dominating 5-1 win and are now putting their ace on the mound in Bryan Woo, who was elite last season and better at home, with a 2.44 home ERA. On the flip side, the Guardians are putting reliever Joey Cantillo on the mound, who was also better on the road in his 20 road games last season. The Mariners bats still look shaky to start the season and with two solid pitchers on the mound I will go under the 7 runs in this one.