Guardians vs Nationals Prediction 5/25/26 MLB Picks Today
Washington Nationals (27-27) vs. Cleveland Guardians (32-23)
May 25, 2026 6:10 pm EDT
The Line: Cleveland Guardians -180 / Washington Nationals 148; Over/Under: 8
(Get latest betting odds)
In this article we will formulate a Guardians vs Nationals prediction for this MLB game on Monday, May 25th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup.
Cleveland Guardians Betting Preview
The Cleveland Guardians are 32-23 this year after they won two out of three against the Phillies by scores of 1-0, 0-3, and 3-1. In game three, Cleveland had their lead cut to 2-1 in the seventh inning, but they added one more run in the eighth to seal the win. The Guardians recorded nine hits in the game and they were led by Bazzana, who went 3-4 with one home run and one RBI. Messick allowed five hits and zero earned runs over 5.2 innings for the win, while Smith picked up the save. Prior to that series, Cleveland swept the Tigers in four games and won two out of three against the Reds.
This season, Cleveland has a 3.55 ERA with a 1.25 WHIP and a .231 opponent batting average, while they have scored 232 runs with a .228 batting average and a .320 on base percentage. Chase DeLauter has led the Guardians with seven home runs and 30 RBIs, while Jose Ramirez has added eight home runs and 24 RBIs. The projected starting pitcher for Cleveland is Tanner Bibee, who is 0-6 with a 3.75 ERA and a 1.25 WHIP over 60.0 innings pitched this year.
Washington Nationals Betting Preview
The Washington Nationals are 27-27 this season after they won two out of three against the Braves by scores of 4-5, 2-0, and 2-1. In game three, Washington led 2-0 after eight innings, but they allowed one run in the ninth and were lucky to escape with the win. The Nationals recorded six hits and they committed one error in the game, while they were led by Garcia Jr, who went 1-1 with one RBI. Griffin allowed three hits and zero earned runs over 6.0 innings for the win, while Ribalta got the save. Prior to that series, Washington split four games with the Mets and won two out of three against the Orioles.
This season, Washington has a 4.80 ERA with a 1.38 WHIP and a .254 opponent batting average, while they have scored 288 runs with a .243 batting average and a .322 on base percentage. CJ Abrams has led the Nationals with 11 home runs and 45 RBIs, while James Wood has added 13 home runs and 34 RBIs. The projected starting pitcher for Washington is Zack Littell, who is 3-4 with a 5.83 ERA and a 1.45 WHIP over 46.1 innings pitched this season.
Why the Cleveland Guardians will win
- The Guardians have won each of their last seven night games after playing the previous day.
- The Nationals have lost each of their last five games against American League opponents that held a winning record.
- The Nationals have failed to cover the run line each of their last five games against American League opponents that held a winning record.
- The Guardians have covered the run line in seven of their last eight home games following a road win.
- The Nationals have lost the first inning in four of their last five games against American League opponents that held a winning record.
- The Nationals have trailed after 3 innings in each of their last four games against American League opponents that held a winning record.
- The Nationals have trailed after 5 innings in each of their last six games against American League opponents that held a winning record.
Why the Washington Nationals will win
- The Guardians have lost eight of their last 10 games as favorites against National League opponents following a road win.
- The Nationals have won three of their last four games as underdogs against AL Central opponents.
- The Nationals have covered the run line in each of their last six games.
- The Guardians have failed to cover the run line in seven of their last eight home games against NL East opponents.
- The Nationals have led after 3 innings in three of their last four games against the Guardians.
- The Guardians have trailed after 5 innings in each of their last four night games at Progressive Field against National League opponents.
Total Runs Facts
- Each of the Guardians’ last six games have gone UNDER the total runs line.
- Each of the Nationals’ last four night games as underdogs have gone OVER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last six games.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Nationals’ last four games.
Cleveland Guardians Player Prop Facts
- Steven Kwan has recorded two or more hits in each of the Guardians’ last four games as favorites against NL East opponents.
- Rhys Hoskins has hit a home run in six of his last eight home appearances against the Nationals after playing the previous day.
- Jose Ramirez ranks 2nd in the league in Steals (20) this season.
Washington Nationals Player Prop Facts
- Jacob Young has hit a home run in each of the Nationals’ last two games against AL opponents.
- CJ Abrams has recorded two hits in each of the Nationals’ last three night games against opponents that held a winning record.
- Nasim Nunez ranks 1st in the league in Steals (22) this season.
Matchup/League Facts
- The Guardians rank 1st in the league for strikeouts this season (515).
- The Guardians rank T2nd in the league for steals this season (54).
- The Nationals rank 1st in the league for runs scored this season (288).
- The Nationals rank 1st in the league for doubles this season (105).
Guardians vs Nationals Prediction
Washington comes into this matchup after stunning the Braves in their series over the weekend and they have allowed two runs or fewer in three of their last four games. The Nationals are 17-11 on the road this year, while the Guardians are 15-10 at home. Cleveland has won five of their last six games and they have allowed two runs or fewer in four of their last five. The Guardians are starting Bibee, who has allowed one earned run in three of his last five starts, while Littell has allowed two earned runs or fewer in four straight outings. The Nationals have finally found some decent pitching and Cleveland plays very low scoring games, so I like the under here.