Guardians vs Red Sox Prediction 4/26/25 MLB Picks Today

In this article, we will formulate a Guardians vs Red Sox prediction for this MLB game on Saturday, April 26th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB doubleheader. 

Boston Red Sox Betting Preview

The Boston Red Sox are 14-13 this year after they lost two out of three games against the Mariners by scores of 8-3, 5-8, and 3-4. In their game three loss, the Red Sox allowed four runs in the first two innings and couldn’t overcome that deficit in the close loss. Boston recorded just four hits in the game, and they were led by Bregman, who went 2-3 with one home run and two RBIs in the loss. Boston started Crochet, who allowed five hits and four earned runs over 5.0 innings in the loss, while Guerrero threw two solid innings in relief. 

Prior to that series, the Red Sox won three out of four against the White Sox and two out of three against the Rays. Boston has lost three of their last five games, and they are currently second in the AL East standings. The Boston pitching staff has a 4.06 ERA with a 1.33 WHIP and a .252 opponent batting average, while their offense has scored 124 runs with a .244 batting average and a .324 on-base percentage this season. Alex Bregman has led Boston with five home runs and 21 RBIs, while Trevor Story has added five home runs and 15 RBIs this year. The projected starting pitcher in game one for Boston is Tanner Houck, who is 0-2 with a 7.66 ERA and a 1.66 WHIP over 24.2 innings pitched this year. The projected starting pitcher for game two is Walker Buehler, who is 3-1 with a 4.23 ERA and a 1.19 WHIP over 27.2 innings pitched this year. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 14-10 this season after they won two out of three against the Yankees by scores of 6-4, 3-2, and 1-5. In that game three loss, Cleveland cut the deficit to 2-1 in the first inning, but failed to score in the final eight innings for the loss. The Guardians recorded five hits in the game, and they were led by Arias, who scored the only run for Cleveland in the loss. Cleveland started Ortiz, who allowed five hits and four earned runs over 4.1 innings pitched in the loss, while Kent allowed three hits and one earned run over 3.0 innings out of the bullpen. 

Prior to that series, the Guardians won all three against the Pirates, but did lose two out of three against the Orioles before that. Cleveland has won five of their last six games, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 3.94 ERA with a 1.38 WHIP and a .251 opponent batting average, while the offense has scored 96 runs with a .235 batting average and a .306 on-base percentage this season. Kyle Manzardo has led Cleveland with seven home runs and 18 RBIs, while Steven Kwan has added four home runs and 14 RBIs this year. The projected starting pitcher for Cleveland in game one is Ben Lively, who is 1-2 with a 3.86 ERA and a 1.25 WHIP over 25.2 innings pitched this season. The projected starter for game two was Logan Allen, but is now Doug Nikhazy, who is making his MLB debut.

Why the Guardians will beat the Red Sox

• The Red Sox have lost nine of their last 11 games as favorites against the Guardians following a loss.
• The Guardians have won three of their last four games as underdogs.
• The Red Sox have failed to cover the run line in 10 of their last 11 games as favorites against the Guardians following a loss.
• The Guardians have covered the run line in each of their last seven Saturday day home games against American League opponents.
• The Guardians have led after 3 innings in four of their last five day games.
• The Red Sox have lost the first inning in three of their last four games against American League opponents.
• The Guardians have led after 5 innings in seven of their last eight Saturday day games.

Why the Red Sox will beat the Guardians

• The Guardians have lost each of their last nine games on the first leg of a doubleheader.
• The Red Sox have won eight of their last nine day games against AL Central opponents following a home loss.
• The Red Sox have covered the run line in each of their last five games against AL Central opponents following a home loss.
• The Guardians have failed to cover the run line in five of their last six games as home underdogs against AL East opponents.
• The Guardians have trailed after 3 innings in four of their last five games against American League opponents.
• The Guardians have lost the first inning in three of their last four games against AL East opponents.
• The Red Sox have led after 5 innings in each of their last four games against AL Central opponents.

Total Runs Facts

• Eight of the Guardians’ last nine home games on the first leg of a doubleheader have gone UNDER the total runs line.
• Six of the Red Sox’s last seven games as road favorites have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Red Sox’s last eight games as road favorites.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last six Saturday games against AL East opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has scored a run in eight of the Guardians’ last nine games as home underdogs against the Red Sox.
• Jose Ramirez has hit at least one home run in three of the Guardians’ last four home games against the Red Sox.
• Jose Ramirez has recorded at least one RBI in four of the Guardians’ last five games against the Red Sox at Progressive Field.
• Steven Kwan has recorded at least one hit in each of his last 12 appearances with the Guardians as home underdogs.
• Steven Kwan has recorded at least one Single in each of his last nine appearances with the Guardians as home underdogs against AL opponents.

Boston Red Sox Player Prop Facts

• Trevor Story has scored at least one run in each of his last six appearances after not playing the previous day.
• Connor Wong has hit a home run in each of his last three appearances with the Red Sox as favorites against the Guardians.
• Connor Wong has recorded an RBI in each of his last four appearances against AL Central opponents.
• Connor Wong has recorded a Double in three of his last four appearances with the Red Sox as favorites against AL Central opponents.
• Alex Bregman has recorded at least one hit in each of his last 12 appearances in day games against AL Central teams that held a winning record.
• Trevor Story has recorded at least one Single in each of his last 10 appearances against AL Central opponents.

Guardians vs Red Sox Prediction 

Boston comes into this series after dropping two out of three against the Mariners, and they are just 6-7 on the road this year. Cleveland is 7-2 at home, and they have plenty of momentum, as they just beat New York two out of three times. In game one, I don’t love either pitcher, and I think we will see plenty of runs, so give me the over. In game two, I originally liked Cleveland with Allen on the mound, but I am going to take Boston now that Nikhazy is starting.