Detroit Tigers (85-71) vs. Cleveland Guardians (84-72)
September 23, 2025 6:40 pm EDT
The Line: Cleveland Guardians 128 / Detroit Tigers -158; Over/Under: 6.5
(Get latest betting odds)
The Detroit Tigers and Cleveland Guardians meet Tuesday in MLB action at Progressive Field. Here’s a Guardians vs Tigers Prediction. This article will include a Guardians vs Tigers Pick.
Detroit Tigers Betting Preview
The Detroit Tigers are 85-71 on the year and play the Red Sox next. The Detroit Tigers are batting .248 on the season, have a .317 OBP, and a .417 slugging percentage. The Detroit Tigers pitching staff has a 3.98 ERA and a 1.25 WHIP. Riley Greene leads the Detroit Tigers with 151 hits and 109 RBI, while Gleyber Torres and Spencer Torkelson have combined for 265 hits and 152 RBI.
Tarik Skubal gets the ball for the Detroit Tigers, and he is 13-5 with a 2.23 ERA and 233 strikeouts this season. Skubal is 3-2 with a 2.40 ERA and 76 strikeouts in his career against the Cleveland Guardians.
Cleveland Guardians Betting Preview
The Cleveland Guardians are 84-72 on the year and play the Rangers next. The Cleveland Guardians are batting .226 on the season, have a .297 OBP, and a .373 slugging percentage. The Cleveland Guardians pitching staff has a 3.71 ERA and a 1.27 WHIP. Steven Kwan leads the Cleveland Guardians with 166 hits and 55 RBI while Jose Ramirez and Kyle Manzardo have combined for 267 hits and 149 RBI.
Gavin Williams gets the ball for the Cleveland Guardians, and he is 11-5 with a 3.06 ERA and 161 strikeouts this season. Williams is 2-2 with a 1.67 ERA and 43 strikeouts in his career against the Detroit Tigers.
Detroit Tigers @ Cleveland Guardians Betting Trends: September 23, 2025
- Probable Starting Pitcher: Gavin Williams Record this season: 11-5 ERA: 3.06
- Home Record: 6-2
- Last 5 against Tigers: 2-1
Why the Cleveland Guardians will win
- The Tigers have lost each of their last six games as favorites.
- The underdogs have won eight of the Tigers’ last nine games.
- The Guardians have covered the run line in each of their last eight games as underdogs.
- The Tigers have failed to cover the run line in each of their last six games.
- The Guardians have won the first inning in each of their last five Tuesday home games.
- The Guardians have led after 5 innings in 13 of their last 14 night games against AL Central opponents.
- The Tigers have trailed after 3 innings in four of their last five games.
- Probable Starting Pitcher: Tarik Skubal Record this season: 13-5 ERA: 2.23
- Road Record: 4-4
- Last 5 against Guardians: 1-1
Why the Detroit Tigers will win
- The road team has won each of the Tigers’ last seven games.
- The Guardians have lost each of their last 11 games as home underdogs against the Tigers following a loss.
- The road team has covered the run line in each of the Tigers’ last seven games.
- The Guardians have failed to cover the run line in 11 of their last 12 games against the Tigers following a road loss.
- The Tigers have led after 5 innings in three of their last four games as road favorites.
Total Runs Facts
- Each of the Guardians’ last six home games have gone UNDER the total runs line.
- Five of the Tigers’ last six road games have gone OVER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Tigers’ last 10 games as road favorites against AL Central opponents.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last five games between the Tigers and Guardians.
Cleveland Guardians Player Prop Facts
- Jose Ramirez has hit a home run in each of the Guardians’ last two games as underdogs.
- Steven Kwan has recorded at least one hit in each of his last six appearances with the Guardians as home underdogs.
- Jose Ramirez ranks 3rd in the league in Steals (40) this season.
Detroit Tigers Player Prop Facts
- Spencer Torkelson has hit a home run in two of the Tigers’ last three games.
- Tarik Skubal has recorded eight or more strikeouts in four of his last five appearances against the Guardians.
- Gleyber Torres has recorded at least one hit in each of the Tigers’ last 11 road games against opponents that held a winning record.
- Tarik Skubal has recorded a win in three of his last four appearances in night games against AL Central teams that held a winning record.
- Zach McKinstry has recorded a Double in each of his last three road appearances against the Guardians after not playing the previous day.
- Tarik Skubal ranks 2nd in the league for total Strikeouts (233) this season.
Matchup/League Facts
- The Guardians rank 30th in the league for hits this season (1157).
- The Guardians rank 30th in the league for batting average this season (.226).
- The Tigers rank 30th in the league for steals this season (60).
- The Tigers rank T2nd in the league for triples this season (36).
Guardians vs Tigers Prediction
The Tigers are worth a look when they have Skubal on the mound, one of the best pitchers in baseball. The problem is the Tigers have just one win since September 11. Meanwhile, the Guardians have lost twice since September 5 and haven’t lost two straight games since September 2. The Guardians have come out of nowhere and are now in the driver’s seat for a playoff spot. Williams has allowed 14 hits and 3 runs in his last 18 innings, and Cleveland has won his last 4 starts. Give me the Guardians.
