LA Dodgers vs Chicago Cubs Prediction 4/25/26 MLB Picks Today

The Chicago Cubs and the Los Angeles Dodgers meet Saturday in MLB action from Dodger Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. Los Angeles Dodgers prediction.

Starting Pitching Matchup

The Chicago Cubs will send out Colin Rea for the start here and Rea is 3-0 with a 3.00 ERA and 26 strikeouts this season. In his last five starts against the Dodgers, Rea is 1-1 with a 5.26 ERA and 21 strikeouts. Roki Sasaki will start for the Dodgers here and Sasaki is 0-2 with a 6.11 ERA and 17 strikeouts this season. In his career, Sasaki is 0-1 with a 2.25 ERA and 6 strikeouts against the Cubs.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their 6-4 win over the Dodgers from Friday’s matchup to sit at 17-9 this season. After this series, the Cubs will head on the road for a series against the San Diego Padres.

Cubs Win Streak Hits Double Digits

Entering Friday, Ian Happ has 23 hits with 4 doubles and a team-high 7 home runs and 14 RBIs while Alex Bregman has 27 hits with 3 doubles, a triple, 2 home runs and 9 RBIs. Nico Hoerner’s added 31 hits with 7 doubles, 4 home runs and 22 RBIs and Moises Ballesteros has 20 hits with 3 home runs and 11 RBIs. Pete Crow-Armstrong’s also added 23 hits with a home run and 7 RBIs as well on the year. Carson Kelly has also contributed 21 hits with 4 doubles, 2 home runs and 10 RBIs. Alex Bregman’s added 27 hits with 3 doubles, a triple, 2 home runs and 9 RBIs and Michael Busch has 18 hits wtih 2 doubles, 2 home runs and 10 RBIs. Dansby Swanson also has 16 hits with 5 home runs and 17 RBIs.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to bounce back from the loss at the hands of the Cubs last time out to slip to 17-9 on the year. After this series, the Dodgers will take on the Miami Marlins in a series at home.

Dodgers Drop 5 Of Last 7

Going into Friday, Andy Pages has 30 hits with 4 doubles, 5 home runs and 21 RBIs while Teoscar Hernandez has 20 hits with 4 doubles, 4 home runs and 13 RBIs. Shohei Ohtani has 23 hits with 4 doubles, 5 home runs and 11 RBIs and Freddie Freeman has 27 hits with 7 doubles, a triple, 3 home runs and 14 RBIs this season. Will Smith and Mookie Betts each have a pair of home runs as well this season. Max Muncy’s added 25 hits with 8 home runs and Kyle Tucker has 23 hits with 3 doubles, 3 home runs and 13 RBIs this season.

The Chicago Cubs @ Los Angeles Dodgers Betting Trends: April 25, 2026

• Probable Starting Pitcher: Roki Sasaki      Record this season: 0-2      ERA: 6.11
• Home Record: 0-2
• Last 5 against Cubs: 0-1

Why the Los Angeles Dodgers will win

• The Dodgers have won each of their last eight Saturday day home games against NL Central opponents.
• The Cubs have lost six of their last seven road games against National League opponents that held a winning record.
• The Cubs have failed to cover the run line each of their last six day games against teams that held a winning record.
• The Dodgers have covered the run line in seven of their last eight home games against NL Central opponents.
• The Cubs have trailed after 5 innings in each of their last six road games against National League opponents that held a winning record.
• The Dodgers have led after 3 innings in six of their last seven day games against the Cubs at UNIQLO Field at Dodger Stadium.

• Probable Starting Pitcher: Colin Rea      Record this season: 3-0      ERA: 3.00
• Road Record: 2-0
• Last 5 against Dodgers: 0-1

Why the Chicago Cubs will win

• The Cubs have won each of their last 10 games.
• The Dodgers have lost three of their last four games as favorites.
• The Dodgers have failed to cover the run line in each of their last seven day games at UNIQLO Field at Dodger Stadium following a loss.
• The Cubs have covered the run line in nine of their last 10 games.
• The Dodgers have trailed after 3 innings in each of their last three home day games.
• The Cubs have led after 5 innings in four of their last five games.

Total Runs Facts

• Seven of the Cubs’ last eight road games have gone OVER the total runs line.
• Four of the last five games between the Cubs and Dodgers have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the last eight games between the Cubs and Dodgers.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Cubs’ last eight games as road underdogs against NL West opponents.

Los Angeles Dodgers Player Prop Facts

• Will Smith has hit a home run in each of his last two appearances against the Cubs.
• Tommy Edman has recorded at least one hit in each of his last eight appearances against NL Central opponents.
• Andy Pages ranks T4th amongst qualified players for Batting Average (.333) this season.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit a home run in three of the Cubs’ last four games.
• Ian Happ has recorded at least one hit in each of his last nine road appearances against NL West opponents.
• Nico Hoerner ranks T6th in the league in Hits (32) this season.

Matchup/League Facts

• The Dodgers rank 1st in the league for home runs this season (43).
• The Dodgers rank 1st in the league for batting average this season (.276).
• The Cubs rank 1st in the league for on-base percentage this season (.357).
• The Cubs rank 3rd in the league for runs scored this season (145).

Chicago Cubs vs. Los Angeles Dodgers Prediction

I’m on the Cubs here. I just think it’s once again where the value lies as I don’t think Roki Sasaki should be laying this kind of price. I’m not the biggest fan of Colin Rea, but this Cubs lineup behind him is swinging a hot bat right now and I think the Cubs get the Dodgers again here. Give me Chicago.