Mets vs Twins Prediction 4/21/26 MLB Picks Today
Minnesota Twins (11-11) vs. NY Mets (7-15)
April 21, 2026 7:10 pm EDT
The Line: NY Mets -186 / Minnesota Twins 153; Over/Under: 7.5
(Get latest betting odds)
In this article we will formulate a Mets vs Twins prediction for this MLB game on Tuesday, April 21st at Citi Field in Queens, New York. Let’s take a look at the prediction for this MLB matchup.
New York Mets Betting Preview
The New York Mets are 7-15 this year after they lost all three against the Cubs by scores of 4-12, 2-4, and 1-2. In game three, New York led 1-0 for most of the game, but they allowed a run in the ninth and lost in the 10th. The Mets recorded six hits in the game and they were led by Melendez, who went 1-4 with one home run and one RBI. Myers opened the game, while Peterson pitched 3.2 scoreless innings and Kimbrel picked up the loss. Prior to that series, New York lost all three against the Dodgers and all three against the Athletics.
This season, New York has a 4.06 ERA with a 1.28 WHIP and a .239 opponent batting average, while they have scored 72 runs with a .226 batting average and a .288 on base percentage. Bo Bichette has led the Mets with one home run and nine RBIs, while Brett Baty has added zero home runs and seven RBIs. The projected starting pitcher for New York is Nolan McLean, who is 1-1 with a 2.28 ERA and a 0.76 WHIP over 23.2 innings pitched this year.
Minnesota Twins Betting Preview
The Minnesota Twins are 11-11 this season after they lost all three against the Reds by scores of 1-2, 4-5, and 4-7. In game three, Minnesota led 3-0 in the third inning, but they needed a run in the ninth to tie the game, before losing in extra innings. The Twins recorded nine hits and they committed three errors, while they were led by Caratini, who went 2-4 with two RBIs in the game. Ober allowed three hits and zero earned runs over 6.1 innings, while Morris allowed three earned runs in relief. Prior to that series, Minnesota lost all three against the Reds, but did win two out of three against the Red Sox before that.
This season, Minnesota has a 4.06 ERA with a 1.37 WHIP and a .253 opponent batting average, while they have scored 112 runs with a .230 batting average and a .332 on base percentage. Josh Bell has led the Twins with three home runs and 15 RBIs, while Tristan Gray has added two home runs and 11 RBIs. The projected starting pitcher for Minnesota is Simeon Woods Richardson, who is 0-3 with a 6.10 ERA and a 1.60 WHIP over 20.2 innings pitched this season.
Why the New York Mets will win
- The Twins have lost each of their last seven road games after going to extra innings.
- The home team has won each of the Mets’ last six games.
- The Twins have failed to cover the run line each of their last nine night games against National League opponents that held a losing record.
- The Mets have covered the run line in seven of their last eight night games at Citi Field after going to extra innings.
- The Twins have trailed after 5 innings in four of their last five games against National League opponents that held a losing record.
- The Twins have trailed after 3 innings in four of their last five road games against NL East opponents that held a losing record.
Why the Minnesota Twins will win
- The Mets have lost each of their last 11 games.
- The underdogs have won seven of the Twins’ last eight games.
- The Mets have failed to cover the run line in each of their last seven home games.
- The Twins have covered the run line in 10 of their last 11 games as road underdogs following a loss.
- The Twins have won the first inning in each of their last four night games against opponents that held a losing record.
- The Mets have trailed after 5 innings in five of their last six home games.
- The Twins have led after 3 innings in each of their last four road games.
Total Runs Facts
- Each of the Twins’ last six road games against NL East opponents have gone UNDER the total runs line.
- Eight of the Mets’ last nine home games following an extra innings loss have gone UNDER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last six games as underdogs.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Mets’ last eight night games at Citi Field.
New York Mets Player Prop Facts
- Bo Bichette has recorded at least one hit in each of his last 15 appearances with his team as a favorite against AL Central opponents.
- Juan Soto has hit a home run in three of the Mets’ last four games against AL Central opponents.
Minnesota Twins Player Prop Facts
- Byron Buxton has hit at least one home run in each of the Twins’ last two night games against opponents that held a losing record.
- Victor Caratini has recorded at least one hit in each of his last seven appearances with his team as a road underdog against NL East opponents.
Matchup/League Facts
- The Mets rank 30th in the league for runs scored this season (72).
- The Mets rank 30th in the league for RBIs this season (68).
- The Twins rank T1st in the league for home runs allowed this season (13).
- The Twins rank T29th in the league for doubles this season (27).
Mets vs Twins Prediction
Both of these teams come into this matchup on losing streaks, so one side will get a much needed win. The Twins are 4-5 on the road this year, while the Mets are 3-6 at home. New York has been swept in three straight series and they have scored two runs or fewer in four of their last five. Minnesota has allowed 5+ runs in three of their last four games and they are starting Woods Richardson, who has allowed 11 earned runs and 16 hits in his last 9.0 innings. New York is going with McLean, who has allowed two earned runs or fewer in four straight outings. Take the Mets -1.5 here.