Brewers vs Reds Prediction 9/27/25 MLB Picks Today
Cincinnati Reds (82-78) vs. Milwaukee Brewers (96-64)
September 27, 2025 7:15 pm EDT
The Line: Milwaukee Brewers -157 / Cincinnati Reds +128; Over/Under: 7.5
(Get latest betting odds)
The Cincinnati Reds and the Milwaukee Brewers meet Saturday in MLB action from American Family Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Brewers vs Reds Prediction.
Starting Pitching Matchup
The Cincinnati Reds will send out Andrew Abbott here and Abbott is 9-7 with a 2.80 ERA and 145 strikeouts this season. In his career, Abbott is 1-3 with a 3.00 ERA and 28 strikeouts against the Brewers. The Milwaukee Brewers will trot out Robert Gasser here and Gasser is 0-1 with a 6.00 ERA and 2 strikeouts this season. This will be Gasser’s first career start against Cincinnati.
Cincinnati Reds Recap
The Cincinnati Reds come into this game looking to add on to their win over the Brewers from Friday’s series opener to sit at 82-78 this season.
Reds Trying To Take Over Wild Card Spot
Elly De La Cruz has 163 hits with 21 home runs, 5 RBIs, 31 doubles and 36 stolen bases while TJ Friedl has 147 hits with 21 doubles, 13 home runs and 50 RBIs with 12 stolen bases. Gavin Lux has added 117 hits with 26 doubles and 53 RBIs while Spencer Steer has 21 home runs and 74 RBIs and Matt McLain has added 15 homers, 49 RBIs and 18 stolen bases as well on the year. Jose Trevino’s also chipped in 20 doubles as well this season.
Why the Cincinnati Reds will win
- The underdogs have won each of the Brewers’ last five games.
- The Brewers have lost each of their last four games as favorites.
- The Brewers have failed to cover the run line in each of their last eight games as favorites against National League opponents.
- The Reds have covered the run line in each of their last eight games as underdogs against National League opponents.
Cincinnati Reds Player Prop Facts
- Spencer Steer has hit a home run in two of his last three road appearances against NL Central opponents.
- Austin Hays has recorded at least one hit in each of his last 10 appearances with the Reds as underdogs.
- Jose Trevino has recorded a Double in each of his last three road appearances against NL Central opponents that held a winning record.
Milwaukee Brewers Recap
The Milwaukee Brewers come into this game looking to bounce back from Thursday’s loss at the hands of the Reds to fall to 96-64 on the year.Â
Brewers Drop 4 Of Last 5
Brice Turang has 165 hits with 18 home runs, 78 RBIs and 24 stolen bases while Jackson Chourio has 145 hits with a team-high 34 doubles, 19 stolen bases, 20 home runs and 77 RBIs and Sal Frelick has 151 hits as well as 3 triples, 12 home runs, 63 RBIs and 19 stolen bases so far this season. Christian Yelich also has 16 stolen bases with 29 homers and 102 RBIs while also adding 20 doubles. Yelich also has a team-high 162 strikeouts up to this point in the year. William Contreras has 17 homers and 76 RBIs as well this season. Joey Ortiz has chipped in 107 hits with 17 doubles, 7 home runs and 45 RBIs and Caleb Durbin also has 25 doubles with 11 homers and 53 RBIs.Â
Why the Milwaukee Brewers will win
- The Brewers have won each of their last nine games against the Reds following a loss.
- The Reds have lost each of their last seven games against the Brewers following a road win.
- The Brewers have covered the run line in each of their last six night games following a home loss.
- The Reds have failed to cover the run line in each of their last four games against the Brewers following a road win.
Milwaukee Brewers Player Prop Facts
- Christian Yelich has recorded a Double in three of the Brewers’ last four home games.
- Christian Yelich has hit a home run in six of the Brewers’ last 14 home games against NL Central opponents.
- Sal Frelick has recorded at least one hit in each of his last 13 appearances against NL Central opponents.
Total Runs Facts
- Seven of the Reds’ last eight road games against National League opponents have gone UNDER the total runs line.
- Five of the Brewers’ last six games have gone UNDER the total runs line.
Brewers vs Reds Prediction
I’m on the Reds in this one. I think the Brewers have bigger fish to fry with the postseason ahead, while it’s do-or-die time for Cincinnati right now. Abbott’s arguably the staff ace, and this is where the Reds need him to be at his best. Lucky for them, Abbott’s been excellent on the road and I think Cincinnati does enough here to get the win and put themselves in a good spot heading into the final day of the season.

