Brewers vs Cardinals Prediction 9/12/25 MLB Picks Today

The St. Louis Cardinals and the Milwaukee Brewers meet Friday in MLB action from American Family Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Brewers vs Cardinals Prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Andre Pallante for the start here and Pallante is 6-13 with a 5.28 ERA and 104 strikeouts this season. In his career, Pallante is 0-1 with a 7.71 ERA and 10 strikeouts against the Brewers. Milwaukee will send out Quinn Priester for the start here and Priester is 12-2 with a 3.25 ERA and 113 strikeouts this season. In his career, Priester is 1-0 with a 4.91 ERA and 5 strikeouts against St. Louis.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from a 4-2 loss at the hands of the Seattle Mariners last time out to sit at 72-75 this season. After this series, the Cardinals will head home for a series against the Cincinnati Reds.

Cardinals Lose Three In A Row

Brendan Donovan has a team-high 118 hits along with 25 doubles, 9 home runs and 45 RBIs while Lars Nootbaar has 109 hits with 13 home runs, 45 RBIs, 22 doubles and 4 stolen bases. Nolan Arenado also has 85 hits with 15 doubles, 10 home runs and 43 RBIs of his own and Victor Scott II has 81 hits with 14 doubles, a triple, 36 RBIs and a team-high 31 stolen bases. Willson Contreras has also chipped in 120 hits with 30 doubles, 20 home runs and 78 RBIs of his own as well this season. Masyn Winn’s added 124 hits with 27 doubles, 9 home runs and 51 RBIs and Alec Burleson’s added 124 hits with 21 doubles, 17 home runs and 62 RBIs.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last six games as underdogs against National League opponents following a loss.
• The Brewers have lost each of their last five games as favorites following a road loss.
• The Brewers have failed to cover the run line in each of their last eight games as favorites following a road loss.
• The underdogs have covered the run line in each of the Brewers’ last six games at American Family Field.

St. Louis Cardinals Player Prop Facts

• Willson Contreras has hit a home run in two of his last three road appearances against NL opponents that held a winning record.
• Alec Burleson has recorded a hit in each of his eight previous appearances against the Brewers after not playing the previous day.
• Victor Scott II ranks T10th in the league in Steals (32) this season.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to bounce back from their 6-3 loss at the hands of the Texas Rangers last time out to drop to 89-58 this season. After this series, the Brewers will take on the Los Angeles Angels in an interleague series at home.

Brewers Trying To Rebound From Sweep

Brice Turang has 154 hits with 18 home runs, 74 RBIs and 24 stolen bases while Jackson Chourio has 135 hits with a team-high 33 doubles, 18 stolen bases, 20 home runs and 72 RBIs and Sal Frelick has 141 hits as well as 3 triples, 10 home runs, 54 RBIs and 19 stolen bases so far this season. Christian Yelich also has 16 stolen bases with 27 homers and 93 RBIs while also adding 18 doubles. Yelich also has a team-high 153 strikeouts up to this point in the year. William Contreras has 17 homers and 71 RBIs as well this season. Joey Ortiz has chipped in 97 hits with 17 doubles, 7 home runs and 44 RBIs and Caleb Durbin also has 22 doubles with 10 homers and 47 RBIs. 

Why the Milwaukee Brewers will win

• The Brewers have won each of their last eight games against NL Central opponents that held a losing record.
• The Cardinals have lost each of their last four road games.
• The Brewers have covered the run line each of their last eight games against NL Central opponents that held a losing record.
• The Cardinals have failed to cover the run line in each of their last five games following a road loss.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit a home run in three of his last four appearances in night games against NL Central teams that held a losing record.
• Andrew Vaughn has recorded a Double in three of the Brewers’ last four games against NL opponents.
• Christian Yelich has recorded at least one hit in each of his last 18 appearances against NL Central opponents that held a losing record.
• Sal Frelick ranks 8th amongst qualified players for Batting Average (.294) this season.

Total Runs Facts

• Seven of the Cardinals’ last eight games following an extra innings loss have gone OVER the total runs line.
• Five of the Brewers’ last six home games against NL Central opponents have gone OVER the total runs line.

Brewers vs Cardinals Prediction

I’m on the Brewers here. Both teams are coming off of being swept, but I think the Brewers’ offense is in a much better place compared to where St. Louis’ offense is at right now. Milwaukee is also the only team going anywhere come playoff time, while the Cards just have some significant issues in terms of drumming up consistent offense. Give me the Brew Crew here.