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Nationals vs Cardinals Prediction 4/7/26 MLB Picks Today

St. Louis Cardinals (5-5) vs. Washington Nationals (4-6)
April 7, 2026 6:45 pm EDT
The Line: Washington Nationals -118 / St. Louis Cardinals -102; Over/Under: 7.5
(Get latest betting odds)

In this article we will formulate a Nationals vs Cardinals prediction for this MLB game on Tuesday, April 7th at Nationals Park in Washington, DC. Let’s take a look at the prediction for this MLB matchup. 

Washington Nationals Betting Preview

The Washington Nationals are 4-6 this year after they won game one in this series by a score of 9-6 on Monday night. Washington led 2-0 in the first inning, but they trailed 5-3 in the eighth, before scoring six runs in the bottom of the eighth for the comeback win. The Nationals recorded 12 hits in the game and they were led by Wood, who went 2-3 with one home run and three RBIs. Littell allowed four hits and one earned run over 5.0 innings in the no decision, while Perez picked up the win. Prior to this series, Washington lost all three against the Dodgers and two out of three against the Phillies. 

This season, Washington has a 6.24 ERA with a 1.63 WHIP and a .281 opponent batting average, while they have scored 64 runs with a .277 batting average and a .352 on base percentage. CJ Abrams has led the Nationals with four home runs and 13 RBIs, while James Wood has added three home runs and nine RBIs. The projected starting pitcher for Washington is Cade Cavalli, who is 0-0 with a 2.79 ERA and a 1.34 WHIP over 9.2 innings pitched this year. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 5-5 this season after they lost game one in this series by a score of 9-6 on Monday. St. Louis led 3-2 in the sixth inning and 6-3 in the eighth, but their bullpen fell apart for the loss. The Cardinals recorded nine hits in the game and they were led by Urias, who went 3-4 with one home run and three RBIs. Pallante allowed three hits and two earned runs over 5.0 innings in the no decision, while Svanson allowed three earned runs and got the loss. Prior to this series, St. Louis lost two out of three against the Tigers, but did win two out of three against the Mets before that. 

This season, St. Louis has a 5.40 ERA with a 1.63 WHIP and a .280 opponent batting average, while they have scored 46 runs with a .222 batting average and a .305 on base percentage. Jordan Walker has led the Cardinals with three home runs and nine RBIs, while Alec Burleson has added one home run and seven RBIs. The projected starting pitcher for St. Louis is Matthew Liberatore, who is 0-0 with a 1.64 ERA and a 1.18 WHIP over 11.0 innings pitched this season. 

Why the Washington Nationals will win

  • The Cardinals have lost seven of their last eight road games.
  • The home team has won five of the Cardinals’ last six games.
  • The Cardinals have failed to cover the run line in seven of their last eight road games.
  • The Nationals have covered the run line in each of their last four night games against National League opponents.
  • The Cardinals have trailed after 3 innings in five of their last six games against NL East opponents that held a losing record.
  • The Cardinals have trailed after 5 innings in each of their last six road games against National League opponents.
  • The Cardinals have lost the first inning in three of their last four road games against National League opponents.

Why the St. Louis Cardinals will win

  • The Nationals have lost four of their last five games as home favorites following a win.
  • The Cardinals have won each of their last three games as road underdogs against NL East opponents following a loss.
  • The Nationals have failed to cover the run line in 10 of their last 11 home games.
  • The road team has covered the run line in seven of the Nationals’ last eight games.
  • The Cardinals have led after 3 innings in four of their last five games at Nationals Park.
  • The Cardinals have led after 5 innings in five of their last six games at Nationals Park.

Total Runs Facts

  • Seven of the Nationals’ last eight home games have gone OVER the total runs line.
  • Each of the Cardinals’ last four games as underdogs against National League opponents have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Nationals’ last four games as favorites against National League opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Cardinals’ last five games as underdogs.

Washington Nationals Player Prop Facts

  • CJ Abrams has hit a home run in four of the Nationals’ last five games.
  • CJ Abrams has recorded at least one hit in each of the Nationals’ last seven games.
  • Nasim Nunez ranks 1st in the league in Steals (5) this season.

St. Louis Cardinals Player Prop Facts

  • Ramon Urias has hit a home run in each of his last two appearances against NL opponents.
  • Lars Nootbaar has recorded at least one hit in each of his last nine road appearances against NL East opponents.

Matchup/League Facts

  • The Nationals rank 30th in the league for ERA this season (6.27).
  • The Nationals rank 30th in the league for opponent batting average this season (.283).
  • The Cardinals rank 30th in the league for strikeouts this season (55).
  • The Cardinals rank 28th in the league for hits allowed this season (87).

Nationals vs Cardinals Prediction 

Washington was able to snap their losing streak with a nice comeback win on Monday, but they have allowed 6+ runs in five straight games. The Nationals are 1-3 at home this year, while the Cardinals are 1-3 on the road. St. Louis has lost three of their last four games, but they have scored 5+ runs in three straight. I don’t trust either starting pitcher, but with the offenses putting up plenty of runs, I like the over here. 

David Racey's Free Pick: Over 7.5

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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