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Nationals vs Giants Prediction 5/25/25 MLB Picks Today

San Francisco Giants (30-22) vs. Washington Nationals (24-28)
May 25, 2025 1:35 pm EDT
The Line: Washington Nationals +136 / San Francisco Giants -162; Over/Under: 8
(Get latest betting odds)

The San Francisco Giants and the Washington Nationals meet Sunday in MLB action from Nationals Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Nationals vs Giants Prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Robbie Ray for the start here and Ray is 6-0 with a 2.67 ERA and 62 strikeouts this season. In his last five starts against the Nationals, Ray is 2-2 with a 5.25 ERA and 23 strikeouts. Michael Soroka will get the start for the Nationals and is 1-2 with a 5.95 ERA and 23 strikeouts this season. In his career, Soroka is 1-1 with a 3.75 ERA and 10 strikeouts.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to bounce back from a 3-0 loss at the hands of the Nationals last time out to slip to 30-22 on the year. After this series, the Giants will head on the road for an interleague series against the Detroit Tigers.

Giants Looking For Some Consistency

Jung Hoo Lee has 56 hits including a team-high 14 doubles along with a pair of triples, 6 home runs and 31 RBIs with 3 stolen bases while Heliot Ramos has 56 hits with 11 doubles, 9 home runs and 26 RBIs. Wilmer Flores also has a team-high 10 home runs and 43 RBIs while Mike Yastrzemski has 5 home runs with 17 RBIs and 9 doubles and Matt Chapman and Tyler Fitzgerald each have a team-high 5 stolen bases as well on the year. Matt Chapman also has 39 hits with 9 home runs and 25 RBIs along with 7 doubles and Willy Adames has 43 hits with 10 doubles, 5 home runs and 24 RBIs.

Why the San Francisco Giants will win

  • The Giants have won seven of their last eight day games against teams that held a losing record.
  • The Nationals have lost each of their last four games against the Giants following a win.
  • The Giants have covered the run line in each of their last nine Sunday road games.
  • The Nationals have failed to cover the run line in each of their last four games against the Giants following a win.

San Francisco Giants Player Prop Facts

  • Mike Yastrzemski has hit a home run in two of the Giants’ last three games as favorites against NL East opponents.
  • Jung Hoo Lee has recorded an RBI in four of the Giants’ last five day games against NL teams that held a losing record.
  • Heliot Ramos has scored at least one run in seven of the Giants’ last eight games as road favorites against NL opponents.
  • Jung Hoo Lee has recorded at least one Single in each of his seven previous appearances against NL East opponents that held a losing record.
  • Jung Hoo Lee has recorded at least one hit in each of his last eight road appearances against NL opponents that held a losing record.
  • Casey Schmitt has recorded a Double in three of his last four appearances with the Giants as favorites against NL opponents.
  • Robbie Ray ranks T3rd in the league for Wins (6) this season.

Washington Nationals Recap

The Washington Nationals will be out to build on their win over the Giants from Saturday’s matchup, improving to 24-28 on the year. After this series, the Nationals will head on the road for a series against the Seattle Mariners in interleague play.

Nationals Win 6 Of Their Last 7

Keibert Ruiz has 49 hits with 9 doubles and a pair of home runs with 20 RBIs while James Wood has 56 hits with 12 doubles and a team-high 12 home runs along with 35 RBIs and 7 stolen bases while also putting up 59 strikeouts. Nathaniel Lowe has 44 hits with 8 doubles and 34 RBIs along with 8 home runs and 59 strikeouts. CJ Abrams has 8 home runs and 19 RBIs along with 9 doubles and 9 stolen bases while Luis Garcia Jr. has 9 doubles and 7 stolen bases of his own this season. Dylan Crews has also logged a team-high 11 stolen bases as well this season.

Why the Washington Nationals will win

  • The underdogs have won each of the Nationals’ last seven games.
  • The Giants have lost each of their last four games as road favorites.
  • The underdogs have covered the run line in 15 of the Giants’ last 16 games.
  • The Giants have failed to cover the run line in each of their last seven games as favorites after playing the previous day.

Washington Nationals Player Prop Facts

  • Keibert Ruiz has recorded a Double in three of the Nationals’ last four games as underdogs against NL opponents.
  • Keibert Ruiz has recorded at least one RBI in four of the Nationals’ last five games as underdogs.
  • Michael Soroka has recorded six or more strikeouts in four of his last five home appearances against NL West opponents.
  • Luis Garcia has recorded at least one Single in eight of his last nine appearances with the Nationals as underdogs against the Giants.
  • Josh Bell has scored at least one run in five of his last six appearances in day games against NL West teams that held a winning record.
  • Paul DeJong has hit a home run in each of his last two appearances with his team as a home underdog against the Giants.
  • Paul DeJong has recorded at least one hit in 12 of his 13 previous home appearances against the Giants.
  • James Wood ranks T10th in the league in Home Runs (13) this season.

Total Runs Facts

  • Each of the Nationals’ last five day games against National League opponents have gone UNDER the total runs line.
  • Six of the Giants’ last seven games have gone UNDER the total runs line.

Nationals vs Giants Prediction

I’m on the Giants in this one. I get the case to be made for the Nationals as a home dog given the run they’ve been on in recent games. But the thing is the Giants have a clear edge in starting pitching with Robbie Ray going here. I just think that the Giants outduel the Nats to get the series win in this one. Give me San Francisco here.

Chris Ruffolo's Free Pick: San Francisco Giants -162

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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