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Nationals vs Mets Prediction 4/26/25 MLB Picks Today

NY Mets (18-7) vs. Washington Nationals (11-14)
April 26, 2025 4:05 pm EDT
The Line: Washington Nationals +150 / NY Mets -180; Over/Under: 9.5
(Get latest betting odds)

The New York Mets and the Washington Nationals meet Saturday in MLB action from Nationals Park. This will be the second installment in a four-game weekend series. Here’s a Nationals vs Mets prediction. We will look at this from a betting perspective and determine the best Nationals vs Mets pick.

New York Mets Betting Preview

New York kicked off the season on a series loss versus the Houston Astros, however next came wins in two of three against the Miami Marlins. The Mets swept the Toronto Blue Jays after that, then took another series win versus Miami. New York bagged a victory in another series versus the A’s then fell in a series versus the Twins ahead of a three-game sweep versus St. Louis. New York beat the Phillies 5-4 and 5-1 in their first two games of this week’s set. On Wednesday in the finale, the Mets posted a pair of runs in the bottom of the 10th inning for a comeback victory 4-3. Brett Baty had a homer with two RBI, and starting pitcher David Peterson went 5.1 innings with two earned on eight hits and a walk.


In Friday’s opener versus the Nationals, New York blew a late lead on the way to a walk-off loss 5-4. Mark Vientos put up three RBI along with his two hits, and starter Kodai Senga had 6.0 innings with two earned on six hits and two walks.

It’ll be Clay Holmes in the starter slot for the Mets on Saturday. This year Holmes is 2-1 with a 3.16 ERA and 34 Ks in five starts over 25.2 innings. Holmes is 26-23 with a 3.67 ERA in 316 career games (nine starts).

Washington Nationals Betting Preview

Over on the Washington side, they fell in their opening set of the year versus the Phillies and then got swept by the Toronto Blue Jays before taking a series victory over the Arizona Diamondbacks. Washington would then win another set against the Los Angeles Dodgers then lost two of three against the Miami Marlins. Following defeats in three of four against the Pirates, Washington would win a set last weekend versus the Rockies. Washington beat the Baltimore Orioles 7-0 in their opener, then on Wednesday they kept it going with a tight win 4-3. In Thursday’s series finale game the Nats couldn’t finish off the sweep, posting a 2-1 loss despite giving up just four hits to the O’s offense.

On Friday in the opener versus New York, Washington posted a 13-8 advantage in hits, with Jose Tena notching three along with two RBI. Dylan Crews also had three hits with three runs. Jake Irvin lasted 7.1 frames in the starting role, giving up one earned on five hits and a walk.

As starting pitcher for Saturday the Nats will go with Brad Lord. This season in his rookie campaign Lord is 0-2 with a 4.73 ERA over six games (three starts. He’s got 10 Ks in 13.1 innings total.

Nationals vs Mets Prediction

I’m staying with the Mets here. Holmes is on a nice run over his last three, though he did have a bit of a spotty win over the Marlins on April 8. In that one Holmes gave up four earned on five hits and three walks in 5.1 innings but still got the W. Since then Holmes is 1-0 in two starts with a combined 11.0 innings, two earned runs, six hits and four walks to his credit. Another nice start like that will set up New York very well Saturday. As for Lord, he’s got one spotty outing in his last three (4.1 innings; four earned in a loss versus the Pirates). In the other pair Lord is 0-1 but he’s got better numbers with two earned over 7.0 combined innings.

The Mets took a tough-luck loss Friday, but I think they’ll bounce back in game two.

Andrew's Free Pick: New York Mets -180

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Andrew

Andrew has been writing about college, professional and fantasy sports betting since 2013. Andrew's goal is to break down the complicated numbers and trends into a language that's easily accessible to novice sports bettors and seasoned professionals alike.

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