Nationals vs Orioles Prediction 4/23/25 MLB Picks Today

In this article, we will formulate a Nationals vs Orioles prediction for this MLB game on Wednesday, April 23, at Nationals Park in Washington, District of Columbia. Let’s take a look at the prediction for this MLB matchup.

Baltimore Orioles Betting Preview

The Baltimore Orioles (9-13, 4-7 Away) were expected to bounce back from the worst display of the season, in which they allowed 24 runs against the Cincinnati Reds. However, not only that they fail to respond, but the Orioles also failed to score a single run in a 7-0 defeat to the Nationals in Game 1 of this series. Dean Kremer took the loss after allowing six runs (five earned) on 11 hits with four strikeouts and no walks in 5.1 innings.

This season, the Orioles average 4.67 runs per game (8th in the MLB) on a .232/.303/.418 slash line. Regarding pitching, the Orioles’ staff has a 5.43 ERA (30th) and 1.60 WHIP (30th). Cedric Mullins leads the Orioles with a .290 batting average, six home runs, and 19 RBI this season.

The projected starting pitcher for the Orioles is Tomoyuki Sugano, who is 2-1 in four starts this season, with a 3.43 ERA and 1.29 WHIP in 21.0 innings.

Washington Nationals Betting Preview

The Washington Nationals (10-13, 6-4 Home) returned home from a three-series road trip during which they lost to the Marlins and Pirates, while they beat the Rockies. For the second time this season, the Nationals kept the opponents off the scoreboard in a 7-0 victory over the Orioles. Nathaniel Lowe and Keibert Ruiz led the offense with two RBI apiece, while Mitchell Parker got the win after allowing no runs on one hit with four strikeouts and two walks over 8.0 innings of work.

This year, the Nationals average 4.23 runs per game (18th in the MLB) on a .229/.305/.368 triple-slash. When it comes to pitching, the Nationals’ staff has a 5.12 ERA (29th) and 1.47 WHIP (27th). Nathaniel Lowe leads the Nats with a .293 batting average, four home runs, and 19 RBI this season.

Trevor Williams will take the mound for the Nationals on Wednesday. The 32-year-old right-hander has a 1-2 record in four starts this year with a 5.95 ERA and 1.63 WHIP in 19.2 innings.

Why the Orioles will beat the Nationals

• The Orioles have won each of their last six Wednesday night games against the Nationals.
• The Nationals have lost six of their last seven games against AL East opponents following a win.
• The Nationals have failed to cover the run line in five of their last six games as underdogs against AL East opponents following a win.
• The Orioles have covered the run line in five of their last six road games following a road loss.

Total Runs Facts

• Each of the Nationals’ last eight games against AL East opponents have gone UNDER the total runs line.
• Six of the Orioles’ last seven games as road favorites have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Orioles’ last nine road games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Nationals’ last seven games at Nationals Park.

Matchup/League Facts

• The Nationals rank T6th in the league for strikeouts against this season (177).
• The Nationals rank T7th in the league for steals this season (25).
• The Orioles rank 30th in the league for hits allowed this season (229).
• The Orioles rank 30th in the league for runs allowed this season (125).

Nationals vs Orioles Prediction

The Nationals won seven of the previous ten H2H encounters, including the last four, and you won’t believe this: each of those four ended with a 7-0 result! I don’t think we will have another 7-0 win for the Nats on Wednesday. In fact, I am backing the Orioles to win because I believe they will field the better starter. Sugano, although a rookie in the MLB, is a 35-year-old experienced pitcher, and he has handled the situation in the majors pretty well thus far. The Orioles’ batter will be eager to bounce back from a couple of duds, so Trevor Williams will be under a lot of pressure early on. I am going with the O’s.