Nationals vs White Sox Prediction 9/26/25 MLB Picks Today

In this article we will formulate a Nationals vs White Sox prediction for this MLB game on Friday, September 26th at Nationals Park in Washington, DC. Let’s take a look at the prediction for this MLB matchup. 

Washington Nationals Betting Preview

The Washington Nationals are 65-94 this year after they lost two out of three against Atlanta by scores of 5-11, 2-3, and 4-3. In their game three win, Washington led 4-1 in the eighth inning, but barely hung on for the victory. The Nationals recorded nine hits in the game and they were led by Wood, who went 2-4 with two home runs and two RBIs in the win. Washington started Alvarez, who allowed two hits and zero earned runs over 4.1 innings, while Parker got the win and Ferrer picked up the save. 

Prior to that series, the Nationals won two out of three against the Mets, but lost all four against the Braves before that. Washington has lost seven of their last ten games and they are last in the NL East standings. The Washington pitching staff has a 5.34 ERA with a 1.45 WHIP and a .268 opponent batting average, while the offense has scored 672 runs with a .242 batting average and a .305 on base percentage this season. James Wood has led Washington with 30 home runs and 92 RBIs, while Josh Bell has added 21 home runs and 62 RBIs this year. The projected starting pitcher for Washington is Cade Cavalli, who is 3-1 with a 4.23 ERA and a 1.43 WHIP over 44.2 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 58-101 this season after they lost all three against the Yankees by scores of 2-3, 1-8, and 3-5. In their game three loss, Chicago led 3-1 in the fourth inning, but failed to score over the last five innings for the loss. The White Sox recorded five hits in the game and they were led by Taylor, who went 1-1 with one home run and two RBIs in the loss. Chicago started Martin, who allowed six hits and three earned runs over 4.1 innings, while Gilbert picked up the loss. 

Prior to that series, the White Sox lost two out of three against the Padres and all three against the Orioles. Chicago has lost 11 of their last 12 games and they are last in the AL Central standings. The Chicago pitching staff has a 4.25 ERA with a 1.37 WHIP and a .248 opponent batting average, while the offense has scored 624 runs with a .231 batting average and a .301 on base percentage this season. Lenyn Sosa has led Chicago with 21 home runs and 72 RBIs, while Andrew Benintendi has added 20 home runs and 63 RBIs this year. The projected starting pitcher for Chicago is Yoendrys Gomez, who is 3-3 with a 4.92 ERA and a 1.39 WHIP over 56.2 innings pitched this season. 

Why the Nationals will beat the White Sox

• The White Sox have lost each of their last 10 games after playing the previous day.
• The favorites have won each of the White Sox’s last 10 games at Nationals Park.
• The Nationals have covered the run line in eight of their last nine games as home favorites against AL Central opponents.
• The White Sox have failed to cover the run line in each of their last five night games following a road loss.
• The White Sox have trailed after 5 innings in each of their last six road night games.
• The Nationals have won the first inning in three of their last four games against AL Central opponents.
• The Nationals have led after 3 innings in five of their last six games.

Total Runs Facts

• Each of the Nationals’ last seven home games against AL Central opponents have gone OVER the total runs line.
• Ten of the White Sox’s last 12 games as underdogs have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Nationals’ last four home games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the White Sox’s last six games against NL East opponents.

Washington Nationals Player Prop Facts

• Luis Garcia has recorded at least one hit in each of the Nationals’ last six games as home favorites against AL opponents.
• Paul DeJong has hit a home run in two of his last three appearances in night games against AL Central teams that held a losing record.
• CJ Abrams has recorded at least one Double in four of his five previous home appearances against AL Central opponents that held a losing record.

Chicago White Sox Player Prop Facts

• Luis Robert has hit a home run in two of his three previous appearances against the Nationals.
• Michael A. Taylor has recorded a Double in each of his last four appearances with the White Sox as road underdogs against NL opponents.
• Mike Tauchman has recorded at least one hit in each of his last nine road appearances against NL opponents.

Matchup/League Facts

• The Nationals rank 29th in the league for ERA this season (5.34).
• The Nationals rank 29th in the league for opponent batting average this season (.268).
• The White Sox rank 29th in the league for slugging percentage this season (.370).
• The White Sox rank 29th in the league for walks allowed this season (590).

Nationals vs White Sox Prediction 

Both of these teams come into this contest at the bottom of their divisions, but Washington does have seven more wins on the year. The Nationals are 31-47 at home this season, while the White Sox are 25-53 on the road. Chicago’s offense continues to be a problem down the stretch and they are going against Cavalli, who has allowed two earned runs or fewer in three of his last four starts. Washington is facing Gomez, who has allowed 3, 2, 4, 1, and 4 earned runs in his last five. I don’t love it, but I will back the Nationals at home with Cavalli on the mound.