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Orioles vs Reds Prediction 4/20/25 MLB Picks Today

Cincinnati Reds (10-11) vs. Baltimore Orioles (9-11)
April 20, 2025 1:35 pm EDT
The Line: Baltimore Orioles -160 / Cincinnati Reds +135; Over/Under:
(Get latest betting odds)

The Cincinnati Reds and Baltimore Orioles meet Sunday in MLB action at Oriole Park at Camden Yards. Here’s a Orioles vs Reds Prediction. This article will include a Orioles vs Reds Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 10-11 on the year and play the Marlins, Rockies, and Cardinals next. The Cincinnati Reds are batting .226 on the season, have a .308 OBP, and a .367 slugging percentage. The Cincinnati Reds pitching staff has a 3.38 ERA and a 1.06 WHIP. TJ Friedl leads the Cincinnati Reds with 23 hits and 9 RBI, while Gavin Lux and Elly De La Cruz have combined for 40 hits and 29 RBI.


Carson Spiers gets the ball for the Cincinnati Reds, and he is 0-2 with a 4.82 ERA and 8 strikeouts this season. This will be Spiers’ first career game against the Baltimore Orioles.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 9-11 on the year and play the Nationals, Tigers, and Yankees next. The Baltimore Orioles are batting .233 on the season, have a .306 OBP, and a .421 slugging percentage. The Baltimore Orioles pitching staff has a 4.47 ERA and a 1.48 WHIP. Cedric Mullins leads the Baltimore Orioles with 18 hits and 19 RBI while Ryan O’Hearn and Ramon Arias have combined for 31 hits and 12 RBI.

Charlie Morton gets the ball for the Baltimore Orioles, and he is 0-4 with a 8.84 ERA and 19 strikeouts this season. Morton is 8-9 with a 4.01 ERA and 87 strikeouts in his career against the Cincinnati Reds.

Why the Baltimore Orioles will win

  • The Reds have lost each of their last eight day games against American League opponents following a loss.
  • The Orioles have won four of their last five games against the Reds.
  • The Reds have failed to cover the run line in each of their last eight day games against American League opponents following a loss.
  • The Orioles have covered the run line in five of their last six day games against National League opponents.
  • The Reds have lost the first inning in four of their last five road games against American League opponents that held a losing record.
  • The Orioles have led after 5 innings in each of their last four day games against National League opponents that held a losing record.
  • The Orioles have led after 3 innings in five of their last six day games against NL Central opponents.

Why the Cincinnati Reds will win

  • The Orioles have lost each of their last eight games against National League opponents following a win.
  • The Reds have won seven of their last eight games as road underdogs against AL East opponents following a loss.
  • The Orioles have failed to cover the run line each of their last seven games against NL Central opponents that held a losing record.
  • The Reds have covered the run line in each of their last six road games following a loss.
  • The Orioles have trailed after 3 innings in each of their last four games at Oriole Park at Camden Yards against NL Central opponents that held a losing record.
  • The Orioles have trailed after 5 innings in each of their last six home games against NL Central opponents that held a losing record.

Matchup/League Facts

  • The Orioles rank 29th in the league for opponent batting average this season (.281).
  • The Orioles rank 28th in the league for strikeouts this season (143).
  • The Reds rank 1st in the league for opponent batting average this season (.201).
  • The Reds rank T29th in the league for triples this season (0).

Orioles vs Reds Prediction

The Orioles are putting together a solid week and look more and more like the team we expected to see from the start. The Orioles should be favored in this spot at home. However, I’m not laying juice with Morton on the mound. Through 18.1 innings, Morton has allowed 24 hits and 18 runs while walking 11. Morton has seen his teams lose each of his last eight starts. It’s awful, folks. Spiers hasn’t been great either, but we’re dealing with a smaller sample size, and we’re also not being asked to lay juice. Spiers’ struggles overall aren’t on the level of Morton. I’ll take a shot with the plus money and the Reds.

Randy Chambers's Free Pick: Cincinnati Reds +135

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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